Reform of United States Weapons Acquisition Policy: Competition, Teaming Agreements, and Dual- Sourcing

Attaining an adequate level of defense at an acceptable cost is as vital and elusive a goal as any the United States has pursued since World War II. No aspect of this goal has proven more vexing than the search for an effective process for purchasing armaments of reasonable price, satisfactory performance, and timely delivery. News accounts abound with reports of serious deficiencies in weapons projects that are central to this country\u27s defense. Recently, the Department of Defense (DOD) and the supplier community have been shaken by a flurry of disclosures and the first indictments emanating from the Department of Justice\u27s investigation of allegations of corruption in weapons acquisition- Operation Ill Wind. \u27 Accounts of inefficiency, poor system performance, and misconduct in individual programs are becoming so common that they obscure what is at stake. Quite simply, failure to solve the problems of weapons procurement will put both the country\u27s economic well-being and its physical security at risk

Correspondence on the introduction of salmon from Scotland into the rivers of Tasmania

Correspondence presented to the Royal Society regarding the introduction of salmon from Scotland to Tasmania dated between 13th August 1849 and the 16th May 1850

Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum

Coronavirus disease 2019 (COVID-19) is a viral infection that can, in severe cases, result in cytokine storm, systemic inflammatory response and coagulopathy that is prognostic of poor outcomes. While some, but not all, laboratory findings appear similar to sepsis-associated disseminated intravascular coagulopathy (DIC), COVID-19- induced coagulopathy (CIC) appears to be more prothrombotic than hemorrhagic. It has been postulated that CIC may be an uncontrolled immunothrombotic response to COVID-19, and there is growing evidence of venous and arterial thromboembolic events in these critically ill patients. Clinicians around the globe are challenged with rapidly identifying reasonable diagnostic, monitoring and anticoagulant strategies to safely and effectively manage these patients. Thoughtful use of proven, evidence-based approaches must be carefully balanced with integration of rapidly emerging evidence and growing experience. The goal of this document is to provide guidance from the Anticoagulation Forum, a North American organization of anticoagulation providers, regarding use of anticoagulant therapies in patients with COVID-19. We discuss in-hospital and post-discharge venous thromboembolism (VTE) prevention, treatment of suspected but unconfirmed VTE, laboratory monitoring of COVID-19, associated anticoagulant therapies, and essential elements for optimized transitions of care specific to patients with COVID-19

Acceptability of Diagnostic Tests for Breast Cancer

Purpose . To assess the acceptability of new non-invasive breast cancer diagnostic tests intended to triage women in need of biopsy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44214/1/10549_2004_Article_5121551.pd

Reviews and bibliographical notices

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\u3ci\u3eFundulus\u3c/i\u3e as the premier teleost model in environmental biology: Opportunities for new insights using genomics

A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms

The Muon Anomalous Magnetic Moment: A Harbinger For "New Physics"

QED, Hadronic, and Electroweak Standard Model contributions to the muon anomalous magnetic moment, a_mu = (g_mu-2)/2, and their theoretical uncertainties are scrutinized. The status and implications of the recently reported 2.6 sigma experiment vs.theory deviation a_mu^{exp}-a_mu^{SM} = 426(165) times 10^{-11} are discussed. Possible explanations due to supersymmetric loop effects with m_{SUSY} \simeq 55 sqrt{tan beta} GeV, radiative mass mechanisms at the 1--2 TeV scale and other ``New Physics'' scenarios are examined.Comment: 24 page

Fermi Large Area Telescope Constraints on the Gamma-ray Opacity of the Universe

The Extragalactic Background Light (EBL) includes photons with wavelengths from ultraviolet to infrared, which are effective at attenuating gamma rays with energy above ~10 GeV during propagation from sources at cosmological distances. This results in a redshift- and energy-dependent attenuation of the gamma-ray flux of extragalactic sources such as blazars and Gamma-Ray Bursts (GRBs). The Large Area Telescope onboard Fermi detects a sample of gamma-ray blazars with redshift up to z~3, and GRBs with redshift up to z~4.3. Using photons above 10 GeV collected by Fermi over more than one year of observations for these sources, we investigate the effect of gamma-ray flux attenuation by the EBL. We place upper limits on the gamma-ray opacity of the Universe at various energies and redshifts, and compare this with predictions from well-known EBL models. We find that an EBL intensity in the optical-ultraviolet wavelengths as great as predicted by the "baseline" model of Stecker et al. (2006) can be ruled out with high confidence.Comment: 42 pages, 12 figures, accepted version (24 Aug.2010) for publication in ApJ; Contact authors: A. Bouvier, A. Chen, S. Raino, S. Razzaque, A. Reimer, L.C. Reye

Measuring Behavior in the Home Cage : Study Design, Applications, Challenges, and Perspectives

FUNDING This research was supported by NIH grants R00AG056662, P20GM125528, AG057424 to WS and SLPeer reviewedPublisher PD