154 research outputs found
Economically sustainable riparian buffer to promote bank stability and reduce gully erosion and phosphorus runoff in the Loess Hills
The project considered what types and configurations of vegetative buffers might be effective in slowing soil loss at a Loess Hills site
The Short Rotation Period of Hi'iaka, Haumea's Largest Satellite
Hi'iaka is the larger outer satellite of the dwarf planet Haumea. Using
relative photometry from the Hubble Space Telescope and Magellan and a phase
dispersion minimization analysis, we have identified the rotation period of
Hi'iaka to be ~9.8 hrs (double-peaked). This is ~120 times faster than its
orbital period, creating new questions about the formation of this system and
possible tidal evolution. The rapid rotation suggests that Hi'iaka could have a
significant obliquity and spin precession that could be visible in light curves
within a few years. We then turn to an investigation of what we learn about the
(presently unclear) formation of the Haumea system and family based on this
unexpectedly rapid rotation rate. We explore the importance of the initial
semi-major axis and rotation period in tidal evolution theory and find they
strongly influence the time required to despin to synchronous rotation,
relevant to understanding a wide variety of satellite and binary systems. We
find that despinning tides do not necessarily lead to synchronous spin periods
for Hi'iaka, even if it formed near the Roche limit. Therefore the short
rotation period of Hi'iaka does not rule out significant tidal evolution.
Hi'iaka's spin period is also consistent with formation near its current
location and spin up due to Haumea-centric impactors.Comment: 21 pages with 6 figures, to be published in The Astronomical Journa
The orbits of the quadruple star system 88 Tau A from PHASES differential astrometry and radial velocity
We have used high precision differential astrometry from the Palomar
High-precision Astrometric Search for Exoplanet Systems (PHASES) project and
radial velocity measurements covering a time-span of 20 years to determine the
orbital parameters of the 88 Tau A system. 88 Tau is a complex hierarchical
multiple system comprising a total of six stars; we have studied the brightest
4, consisting of two short-period pairs orbiting each other with an 18-year
period. We present the first orbital solution for one of the short-period
pairs, and determine the masses of the components and distance to the system to
the level of a few percent. In addition, our astrometric measurements allow us
to make the first determination of the mutual inclinations of the orbits. We
find that the sub-systems are not coplanar.Comment: Corrected Author Ordering; 12 Pages, Accepted for publication in Ap
The Two States of Star Forming Clouds
We examine the effects of self-gravity and magnetic fields on supersonic
turbulence in isothermal molecular clouds with high resolution simulations and
adaptive mesh refinement. These simulations use large root grids (512^3) to
capture turbulence and four levels of refinement to capture high density, for
an effective resolution of 8,196^3. Three Mach 9 simulations are performed, two
super-Alfv\'enic and one trans-Alfv\'enic. We find that gravity splits the
clouds into two populations, one low density turbulent state and one high
density collapsing state. The low density state exhibits properties similar to
non-self-gravitating in this regime, and we examine the effects of varied
magnetic field strength on statistical properties: the density probability
distribution function is approximately lognormal; velocity power spectral
slopes decrease with field strength; alignment between velocity and magnetic
field increases with field; the magnetic field probability distribution can be
fit to a stretched exponential. The high density state is characterized by
self-similar spheres; the density PDF is a power-law; collapse rate decreases
with increasing mean field; density power spectra have positive slopes,
P({\rho},k) \propto k; thermal-to-magnetic pressure ratios are unity for all
simulations; dynamic-to-magnetic pressure ratios are larger than unity for all
simulations; magnetic field distribution is a power-law. The high Alfv\'en Mach
numbers in collapsing regions explain recent observations of magnetic influence
decreasing with density. We also find that the high density state is found in
filaments formed by converging flows, consistent with recent Herschel
observations. Possible modifications to existing star formation theories are
explored.Comment: 19 pages, 20 figure
Tendon–bone contact pressure and biomechanical evaluation of a modified suture-bridge technique for rotator cuff repair
The aim of the study was to evaluate the time-zero mechanical and footprint properties of a suture-bridge technique for rotator cuff repair in an animal model. Thirty fresh-frozen sheep shoulders were randomly assigned among three investigation groups: (1) cyclic loading, (2) load-to-failure testing, and (3) tendon–bone interface contact pressure measurement. Shoulders were cyclically loaded from 10 to 180 N and displacement to gap formation of 5- and 10-mm at the repair site. Cycles to failure were determined. Additionally, the ultimate tensile strength and stiffness were verified along with the mode of failure. The average contact pressure and pressure pattern were investigated using a pressure-sensitive film system. All of the specimens resisted against 3,000 cycles and none of them reached a gap formation of 10 mm. The number of cycles to 5-mm gap formation was 2,884.5 ± 96.8 cycles. The ultimate tensile strength was 565.8 ± 17.8 N and stiffness was 173.7 ± 9.9 N/mm. The entire specimen presented a unique mode of failure as it is well known in using high strength sutures by pulling them through the tendon. We observed a mean contact pressure of 1.19 ± 0.03 MPa, applied on the footprint area. The fundamental results of our study support the use of a suture-bridge technique for optimising the conditions of the healing biology of a reconstructed rotator cuff tendon. Nevertheless, an individual estimation has to be done if using the suture-bridge technique clinically. Further investigation is necessary to evaluate the cell biological healing process in order to achieve further sufficient advancements in rotator cuff repair
Tandem E2F Binding Sites in the Promoter of the p107 Cell Cycle Regulator Control p107 Expression and Its Cellular Functions
The retinoblastoma tumor suppressor (Rb) is a potent and ubiquitously expressed cell cycle regulator, but patients with a germline Rb mutation develop a very specific tumor spectrum. This surprising observation raises the possibility that mechanisms that compensate for loss of Rb function are present or activated in many cell types. In particular, p107, a protein related to Rb, has been shown to functionally overlap for loss of Rb in several cellular contexts. To investigate the mechanisms underlying this functional redundancy between Rb and p107 in vivo, we used gene targeting in embryonic stem cells to engineer point mutations in two consensus E2F binding sites in the endogenous p107 promoter. Analysis of normal and mutant cells by gene expression and chromatin immunoprecipitation assays showed that members of the Rb and E2F families directly bound these two sites. Furthermore, we found that these two E2F sites controlled both the repression of p107 in quiescent cells and also its activation in cycling cells, as well as in Rb mutant cells. Cell cycle assays further indicated that activation of p107 transcription during S phase through the two E2F binding sites was critical for controlled cell cycle progression, uncovering a specific role for p107 to slow proliferation in mammalian cells. Direct transcriptional repression of p107 by Rb and E2F family members provides a molecular mechanism for a critical negative feedback loop during cell cycle progression and tumorigenesis. These experiments also suggest novel therapeutic strategies to increase the p107 levels in tumor cells
Facial Skin Coloration Affects Perceived Health of Human Faces
Numerous researchers have examined the effects of skin condition, including texture and color, on the perception of health, age, and attractiveness in human faces. They have focused on facial color distribution, homogeneity of pigmentation, or skin quality. We here investigate the role of overall skin color in determining perceptions of health from faces by allowing participants to manipulate the skin portions of color-calibrated Caucasian face photographs along CIELab color axes. To enhance healthy appearance, participants increased skin redness (a*), providing additional support for previous findings that skin blood color enhances the healthy appearance of faces. Participants also increased skin yellowness (b*) and lightness (L*), suggesting a role for high carotenoid and low melanin coloration in the healthy appearance of faces. The color preferences described here resemble the red and yellow color cues to health displayed by many species of nonhuman animals
Testing in Mice the Hypothesis That Melanin Is Protective in Malaria Infections
Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern humans originated in Africa and lost skin melanization as they migrated to temperate regions of the globe. Although it is well documented that loss of melanization improved cutaneous Vitamin D synthesis, melanin plays an evolutionary ancient role in insect immunity to malaria and in some instances melanin has been implicated to play an immunoregulatory role in vertebrates. Thus, we tested the hypothesis that melanization may be protective in malaria infections using mouse models. Congenic C57BL/6 mice that differed only in the gene encoding tyrosinase, a key enzyme in the synthesis of melanin, showed no difference in the clinical course of infection by Plasmodium yoelii 17XL, that causes severe anemia, Plasmodium berghei ANKA, that causes severe cerebral malaria or Plasmodium chabaudi AS that causes uncomplicated chronic disease. Moreover, neither genetic deficiencies in vitamin D synthesis nor vitamin D supplementation had an effect on survival in cerebral malaria. Taken together, these results indicate that neither melanin nor vitamin D production improve survival in severe malaria
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Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach
We present a data-driven mathematical model of a key initiating step in platelet activation, a central process in the prevention of bleeding following Injury. In vascular disease, this process is activated inappropriately and causes thrombosis, heart attacks and stroke. The collagen receptor GPVI is the primary trigger for platelet activation at sites of injury. Understanding the complex molecular mechanisms initiated by this receptor is important for development of more effective antithrombotic medicines. In this work we developed a series of nonlinear ordinary differential equation models that are direct representations of biological hypotheses surrounding the initial steps in GPVI-stimulated signal transduction. At each stage model simulations were compared to our own quantitative, high-temporal experimental data that guides further experimental design, data collection and model refinement. Much is known about the linear forward reactions within platelet signalling pathways but knowledge of the roles of putative reverse reactions are poorly understood. An initial model, that includes a simple constitutively active phosphatase, was unable to explain experimental data. Model revisions, incorporating a complex pathway of interactions (and specifically the phosphatase TULA-2), provided a good description of the experimental data both based on observations of phosphorylation in samples from one donor and in those of a wider population. Our model was used to investigate the levels of proteins involved in regulating the pathway and the effect of low GPVI levels that have been associated with disease. Results indicate a clear separation in healthy and GPVI deficient states in respect of the signalling cascade dynamics associated with Syk tyrosine phosphorylation and activation. Our approach reveals the central importance of this negative feedback pathway that results in the temporal regulation of a specific class of protein tyrosine phosphatases in controlling the rate, and therefore extent, of GPVI-stimulated platelet activation
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