A Comparison of the Technological Maturation of SmallSat Propulsion Systems from 2018 to 2020

The maturity in small spacecraft technology is indicated by the continued growth in the number of missions, mission complexity, and the expansion of smallsat subsystem capability. Identified development paths include the consideration of systems and components with flight heritage on larger spacecraft to meet the needs of smaller platforms, the conception of novel technologies specifically designed for small spacecraft, and the incremental improvements every 1-2 years in components where the underlying technology remains unchanged. Progress of overall smallsat technology development is captured in the most recent 2020 State-of-the-Art Small Spacecraft Technology (SoA) report, the objective of which is to assess and provide an overview on the current development status across all subsystem architectures. The SoA report contains a variety of surveys covering device performance, capabilities, and flight history, as presented in publicly available literature. The focus of these surveys is on devices or systems that can be commercially procured or appear on a path towards commercial availability. The work toward the 2020 edition of the report was managed by NASA’s Small Spacecraft Systems Virtual Institute (S3VI) and performed by several contractor staff. The S3VI is jointly funded by NASA’s Space Technology Mission Directorate and Science Mission Directorate. Technological advancement varies across subsystems, and smallsat propulsion technology has had a rapid increase in quantity and type in the last few years that is documented in the SoA report. The extensive efforts made by industry, academia, and government entities to develop and mature small spacecraft propulsive technologies suggest a range of devices with diverse capabilities will become more readily available in near future. While the report uses the NASA Technology Readiness Level scale to measure technical maturity, the “In-Space Propulsion” chapter implemented a novel classification system that recognized Progress towards Mission Infusion (PMI) as an early indicator of the efficacy of the manufacturers’ approach to system maturation and mission infusion. Readers of this paper are highly encouraged to refer to the “In-Space Propulsion” chapter for further information on the PMI classifications. A driving trend captured in the SoA report is that smallsat missions are becoming more complex in the anticipation of using smallsats to collect lunar and deep space science. Smallsat propulsive technology must mature operationally to meet the needs of the increasing smallsat mission complexity. This paper will expand upon the progression of technical maturation identified in the “In-Space Propulsion” chapter presented in the 2020 report and compare these developmental achievements to the “Propulsion” chapter in the 2018 SoA report. By making these comparisons, the reader will be able to measure the degree of advancement in smallsat propulsion technology that has been made in the last few years, understand the specific development approaches propulsion engineers encounter, and learn about the current trends in smallsat propulsion

Small Satellite Reliability Initiative (SSRI) Knowledge Base Tool: Use Case Review and Future Functionality and Content Direction

The Small Satellite Reliability Initiative (SSRI) Knowledge Base is a comprehensive and searchable online tool that consolidates and organizes resources, best practices, and lessons learned from previous small satellite missions sponsored by NASA, other government agencies, and academia. This free, publicly available tool is available to the entire SmallSat Community. The SSRI Knowledge Base provides vetted, high-quality sources of information on elements that are key to successful small satellite missions. These resources include SSRI working group generated documents and presentations in addition to existing guides, publications, standards, software tools, websites, and books. The Knowledge Base is fully searchable, offers downloadable content when possible, and otherwise links to or references content directly from within the tool. This presentation and paper will discuss the motivation for the SSRI Knowledge Base, review educational use cases, and outline plans for further development. The SSRI is a collaborative activity with broad participation from civil, U.S. Department of Defense, and both national and international commercial space systems providers and stakeholders. NASA’s Small Spacecraft Systems Virtual Institute (S3VI) funds the SSRI Knowledge Base. The S3VI is jointly sponsored by NASA’s Space Technology Mission Directorate and Science Mission Directorate

Using Information from Rendezvous Missions for Best-Case Appraisals of Impact Damage to Planet Earth Caused by Natural Objects

The Asteroid Threat Assessment Project (ATAP), a part of NASAs Planetary Defense Coordination Office (PDCO) has the responsibility to appraise the range of surface damage by potential asteroid impacts on land or water. If a threat is realized, the project will provide appraisals to officials empowered to make decisions about potential mitigation actions. This paper describes a scenario for assessment of surface damage when characterization of an asteroid had been accomplished by a rendezvous mission that would be conducted by the international planetary defense community. It is shown that the combination of data from ground and in-situ measurements on an asteroid provides knowledge that can be used to pin-point its impact location and predict the level of devastation it would cause. The hypothetical asteroid 2017 PDC with a size range of 160 to 290 m in diameter to be discussed at the PDC 2017 is used as an example. In order of importance for appraising potential damage, information required is: (1) where will the surface impact occur? (2) what is the mass, shape and size of the asteroid and what is its entry state (speed and entry angle) at the 100 km atmospheric pierce point? And (3) is the asteroid a monolith or a rubble pile? If it is a rubble pile, what is its structure and heterogeneity from the surface and throughout its interior? Item (1) is of first order importance to determine levels of devastation (loss of life and infrastructure damage) because it varies strongly on the impact location. Items (2) and (3) are used as inputs for ATAPs simulations to define the level of surface hazards: winds, overpressure, thermal exposure; all created by the deposition of energy during the objects atmospheric flight, andor cratering. Topics presented in this paper include: (i) the devastation predicted by 2017 PDCs impact on land based on initial observations using ATAPs risk assessment capability, (ii) how information corresponding to items (1) to (3) could be obtained from a rendezvous mission, and (iii) how information from a rendezvous mission could be used, along with that from ground observations and data from the literature to provide input for a new risk analysis capability that is emerging from ATAPs research. It is concluded that this approach would result in the creation of an appraisal of the threat from 2017 PDC with the least uncertainty possible, herein called the best-case

Using Information from Rendezvous Missions For Best-Case Appraisals of Impact Damage to Planet Earth Caused By Natural Objects

The Asteroid Threat Assessment Project (ATAP), a part of NASAs Planetary Defense Coordination Office (PDCO) has the responsibility to appraise the range of surface damage by potential asteroid impacts on land or water. If a threat is realized, the project will provide appraisals to officials empowered to make decisions on potential mitigation actions. This paper describes a scenario for assessment of surface damage when characterization of an asteroid had been accomplished by a rendezvous mission that would be conducted by the international planetary defense community. It is shown that the combination of data from ground and in-situ measurements on an asteroid provides knowledge that can be used to pin-point its impact location and predict the level of devastation it would cause. The hypothetical asteroid 2017 PDC with a size of 160 to 290 m in diameter to be discussed at the PDC 2017 meeting is used as an example. In order of importance for appraising potential damage, information required is: (1) where will the surface impact occur? (2) What is the mass, shape and size of the asteroid and what is its entry state (speed and entry angle) at the 100 km atmospheric pierce point? And (3) is the asteroid a monolith or a rubble pile? If it is a rubble pile, what is its sub and interior structure? Item (1) is of first order importance to determine levels of devastation (loss of life and infrastructure damage) because it varies strongly on the impact location. Items (2) and (3) are used as input for ATAPs simulations to define the level of surface hazards: winds, overpressure, thermal exposure; all created by the deposition of energy during the objects atmospheric flight, and/or cratering. Topics presented in this paper include: (i) The devastation predicted by 2017 PDCs impact based on initial observations using ATAPs risk assessment capability, (ii) How information corresponding to items (1) to (3) could be obtained from a rendezvous mission, and (iii) How information from a rendezvous mission could be used, along with that from ground observations and data from the literature, could provide input for an new risk analysis capability that is emerging from ATAPs research. It is concluded that this approach would result in appraisal with the least uncertainty possible (herein called the best-case) using simulation capabilities that are currently available or will be in the future

Small Spacecraft Systems Virtual Institute's Federated Databases and State of the Art of Small Spacecraft Technology Report

NASA's Small Spacecraft Systems Virtual Institute (S3VI) is collaborating with the Air Force Research Laboratory and Space Dynamics Laboratory on the development of a small spacecraft parts database called SmallSat Parts On Orbit Now (SPOON). The SPOON database contains small spacecraft parts and technologies categorized by major satellite subsystems developed by industry, academia and government. The State of the Art of Small Spacecraft Technology report reflects small spacecraft parts submitted to the SPOON database and technologies compiled from other sources that were assessed as the current state of the art in each of the major subsystems. The report, first commissioned by NASA's Small Spacecraft Technology Program in mid-2013, is developed in response to the continuing growth in interest in using small spacecraft for many types of missions in Earth orbit and beyond. Due to the high market penetration of CubeSats, particular emphasis is placed on the state of the art of CubeSat-related technology. The 2018 report is planned for release in late summer. A review of SPOON database functionality, federation of additional NASA-internal and external databases along with a common search capability, as well as an overview of the State of the Art of Small Spacecraft Technology report will be presented. The S3VI is jointly sponsored by NASA's Space Technology Mission Directorate and Science Mission Directorate

Psychotropic medication use among nursing home residents in Austria: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>The use of psychotropic medications and their adverse effects in frail elderly has been debated extensively. However, recent data from European studies show that these drugs are still frequently prescribed in nursing home residents. In Austria, prevalence data are lacking. We aimed to determine the prevalence of psychotropic medication prescription in Austrian nursing homes and to explore characteristics associated with their prescription.</p> <p>Methods</p> <p>Cross-sectional study and association analysis in forty-eight out of 50 nursing homes with 1844 out of a total of 2005 residents in a defined urban-rural region in Austria. Prescribed medication was retrieved from residents' charts. Psychotropic medications were coded according to the Anatomical Therapeutic Chemical Classification 2005. Cluster-adjusted multiple logistic regression analysis was performed to investigate institutional and residents' characteristics associated with prescription.</p> <p>Results</p> <p>Residents' mean age was 81; 73% of residents were female. Mean cluster-adjusted prevalence of residents with at least one psychotropic medication was 74.6% (95% confidence interval, CI, 72.0–77.2). A total of 45.9% (95% CI 42.7–49.1) had at least one prescription of an antipsychotic medication. Two third of all antipsychotic medications were prescribed for bedtime use only. Anxiolytics were prescribed in 22.2% (95% CI 20.0–24.5), hypnotics in 13.3% (95% CI 11.3–15.4), and antidepressants in 36.8% (95% CI 34.1–39.6) of residents. None of the institutional characteristics and only few residents' characteristics were significantly associated with psychotropic medication prescription. Permanent restlessness was positively associated with psychotropic medication prescription (AOR 1.54, 95% CI 1.32–1.79) whereas cognitive impairment was inversely associated (AOR 0.70, 95% CI 0.56–0.88).</p> <p>Conclusion</p> <p>Frequency of psychotropic medication prescription is high in Austrian nursing homes compared to recent published data from other countries. Interventions should aim at reduction and optimisation of prescriptions.</p

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aeruginosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P. aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution in Enabling its Functional Interactions with NEFs

Catalysis of ADP-ATP exchange by nucleotide exchange factors (NEFs) is central to the activity of Hsp70 molecular chaperones. Yet, the mechanism of interaction of this family of chaperones with NEFs is not well understood in the context of the sequence evolution and structural dynamics of Hsp70 ATPase domains. We studied the interactions of Hsp70 ATPase domains with four different NEFs on the basis of the evolutionary trace and co-evolution of the ATPase domain sequence, combined with elastic network modeling of the collective dynamics of the complexes. Our study reveals a subtle balance between the intrinsic (to the ATPase domain) and specific (to interactions with NEFs) mechanisms shared by the four complexes. Two classes of key residues are distinguished in the Hsp70 ATPase domain: (i) highly conserved residues, involved in nucleotide binding, which mediate, via a global hinge-bending, the ATPase domain opening irrespective of NEF binding, and (ii) not-conserved but co-evolved and highly mobile residues, engaged in specific interactions with NEFs (e.g., N57, R258, R262, E283, D285). The observed interplay between these respective intrinsic (pre-existing, structure-encoded) and specific (co-evolved, sequence-dependent) interactions provides us with insights into the allosteric dynamics and functional evolution of the modular Hsp70 ATPase domain