Non-renormalizability of noncommutative SU(2) gauge theory

We analyze the divergent part of the one-loop effective action for the noncommutative SU(2) gauge theory coupled to the fermions in the fundamental representation. We show that the divergencies in the 2-point and the 3-point functions in the $\theta$-linear order can be renormalized, while the divergence in the 4-point fermionic function cannot.Comment: 15 pages, results presented at ESI 2d dilaton gravity worksho

Soil protist function varies with elevation in the Swiss Alps

Protists are abundant and play key trophic functions in soil. Documenting how their trophic contributions vary across large environmental gradients is essential to understand and predict how biogeochemical cycles will be impacted by global changes. Here, using amplicon sequencing of environmental DNA in open habitat soil from 161 locations spanning 2600 m of elevation in the Swiss Alps (from 400 to 3000 m), we found that, over the whole study area, soils are dominated by consumers, followed by parasites and phototrophs. In contrast, the proportion of these groups in local communities shows large variations in relation to elevation. While there is, on average, three times more consumers than parasites at low elevation (400–1000 m), this ratio increases to 12 at high elevation (2000–3000 m). This suggests that the decrease in protist host biomass and diversity toward mountains tops impact protist functional composition. Furthermore, the taxonomic composition of protists that infect animals was related to elevation while that of protists that infect plants or of protist consumers was related to soil pH. This study provides a first step to document and understand how soil protist functions vary along the elevational gradient

Controls on Ice Cliff Distribution and Characteristics on Debris-Covered Glaciers

Ice cliff distribution plays a major role in determining the melt of debris-covered glaciers but its controls are largely unknown. We assembled a data set of 37,537 ice cliffs and determined their characteristics across 86 debris-covered glaciers within High Mountain Asia (HMA). We find that 38.9% of the cliffs are stream-influenced, 19.5% pond-influenced and 19.7% are crevasse-originated. Surface velocity is the main predictor of cliff distribution at both local and glacier scale, indicating its dependence on the dynamic state and hence evolution stage of debris-covered glacier tongues. Supraglacial ponds contribute to maintaining cliffs in areas of thicker debris, but this is only possible if water accumulates at the surface. Overall, total cliff density decreases exponentially with debris thickness as soon as the debris layer reaches a thickness of over 10 cm

Anisotropy parameterization development and evaluation for glacier surface albedo retrieval from satellite observations.

Glacier albedo determines the net shortwave radiation absorbed at the glacier surface and plays a crucial role in glacier energy and mass balance. Remote sensing techniques are efficient means to retrieve glacier surface albedo over large and inaccessible areas and to study its variability. However, corrections of anisotropic reflectance of glacier surface have been established for specific shortwave bands only, such as Landsat 5 Thematic Mapper (L5/TM) band 2 and band 4, which is a major limitation of current retrievals of glacier broadband albedo. In this study, we calibrated and evaluated four anisotropy correction models for glacier snow and ice, applicable to visible, near-infrared and shortwave-infrared wavelengths using airborne datasets of Bidirectional Reflectance Distribution Function (BRDF). We then tested the ability of the best-performing anisotropy correction model, referred to from here on as the ‘updated model’, to retrieve albedo from L5/TM, Landsat 8 Operational Land Imager (L8/OLI) and Moderate Resolution Imaging Spectroradiometer (MODIS) imagery, and evaluated these results with field measurements collected on eight glaciers around the world. Our results show that the updated model: (1) can accurately estimate anisotropic factors of reflectance for snow and ice surfaces; (2) generally performs better than prior approaches for L8/OLI albedo retrieval but is not appropriate for L5/TM; (3) generally retrieves MODIS albedo better than the MODIS standard albedo product (MCD43A3) in both absolute values and glacier albedo temporal evolution, i.e., exhibiting both fewer gaps and better agreement with field observations. As the updated model enables anisotropy correction of a maximum of 10 multispectral bands and is implemented in Google Earth Engine (GEE), it is promising for observing and analyzing glacier albedo at large spatial scales

Expression profiling of potato germplasm differentiated in quality traits leads to the identification of candidate flavour and texture genes

Quality traits such as flavour and texture are assuming a greater importance in crop breeding programmes. This study takes advantage of potato germplasm differentiated in tuber flavour and texture traits. A recently developed 44 000-element potato microarray was used to identify tuber gene expression profiles that correspond to differences in tuber flavour and texture as well as carotenoid content and dormancy characteristics. Gene expression was compared in two Solanum tuberosum group Phureja cultivars and two S. tuberosum group Tuberosum cultivars; 309 genes were significantly and consistently up-regulated in Phureja, whereas 555 genes were down-regulated. Approximately 46% of the genes in these lists can be identified from their annotation and amongst these are candidates that may underpin the Phureja/Tuberosum trait differences. For example, a clear difference in the cooked tuber volatile profile is the higher level of the sesquiterpene α-copaene in Phureja compared with Tuberosum. A sesquiterpene synthase gene was identified as being more highly expressed in Phureja tubers and its corresponding full-length cDNA was demonstrated to encode α-copaene synthase. Other potential ‘flavour genes’, identified from their differential expression profiles, include those encoding branched-chain amino acid aminotransferase and a ribonuclease suggesting a mechanism for 5′-ribonucleotide formation in potato tubers on cooking. Major differences in the expression levels of genes involved in cell wall biosynthesis (and potentially texture) were also identified, including genes encoding pectin acetylesterase, xyloglucan endotransglycosylase and pectin methylesterase. Other gene expression differences that may impact tuber carotenoid content and tuber life-cycle phenotypes are discussed

Evaluation of sesamum gum as an excipient in matrix tablets

In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations

Early childhood tumours arise from transformed embryonic cells, which often carry large copy number alterations (CNA). However, it remains unclear how CNAs contribute to embryonic tumourigenesis due to a lack of suitable models. Here we employ female human embryonic stem cell (hESC) differentiation and single-cell transcriptome and epigenome analysis to assess the effects of chromosome 17q/1q gains, which are prevalent in the embryonal tumour neuroblastoma (NB). We show that CNAs impair the specification of trunk neural crest (NC) cells and their sympathoadrenal derivatives, the putative cells-of-origin of NB. This effect is exacerbated upon overexpression of MYCN, whose amplification co-occurs with CNAs in NB. Moreover, CNAs potentiate the pro-tumourigenic effects of MYCN and mutant NC cells resemble NB cells in tumours. These changes correlate with a stepwise aberration of developmental transcription factor networks. Together, our results sketch a mechanistic framework for the CNA-driven initiation of embryonal tumours