24 research outputs found
Capacity of deepâsea corals to obtain nutrition from cold seeps aligned with microbiome reorganization
- Author
- Publication venue
- Wiley
- Publication date
- 01/01/2023
- Field of study
Cold seeps in the deep sea harbor various animals that have adapted to utilize seepage chemicals with the aid of chemosynthetic microbes that serve as primary producers. Corals are among the animals that live near seep habitats and yet, there is a lack of evidence that corals gain benefits and/or incur costs from cold seeps. Here, we focused on Callogorgia delta and Paramuricea sp. type B3 that live near and far from visual signs of currently active seepage at five sites in the deep Gulf of Mexico. We tested whether these corals rely on chemosynthetically-derived food in seep habitats and how the proximity to cold seeps may influence; (i) coral colony traits (i.e., health status, growth rate, regrowth after sampling, and branch loss) and associated epifauna, (ii) associated microbiome, and (iii) host transcriptomes. Stable isotope data showed that many coral colonies utilized chemosynthetically derived food, but the feeding strategy differed by coral species. The microbiome composition of C. delta, unlike Paramuricea sp., varied significantly between seep and non-seep colonies and both coral species were associated with various sulfur-oxidizing bacteria (SUP05). Interestingly, the relative abundances of SUP05 varied among seep and non-seep colonies and were strongly correlated with carbon and nitrogen stable isotope values. In contrast, the proximity to cold seeps did not have a measurable effect on gene expression, colony traits, or associated epifauna in coral species. Our work provides the first evidence that some corals may gain benefits from living near cold seeps with apparently limited costs to the colonies. Cold seeps provide not only hard substrate but also food to cold-water corals. Furthermore, restructuring of the microbiome communities (particularly SUP05) is likely the key adaptive process to aid corals in utilizing seepage-derived carbon. This highlights that those deep-sea corals may upregulate particular microbial symbiont communities to cope with environmental gradients
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National scale evaluation of the InVEST nutrient retention model in the United Kingdom
- Author
- Aguiar
- Arheimer
- Arnold
- Bai
- Baker
- Beale
- Boithias
- Bowes
- Bowes
- Braat
- Brazier
- Breuer
- Core Team
- Darch
- Defew
- Dennedy-Frank
- Dillon
- Dolan
- Drewry
- Dunn
- Edwards
- Envrionment Agency
- Feng
- Fisher
- Foster
- Fozzard
- Fry
- Grafius
- Hamel
- Hamel
- Hamel
- Hamel
- Heathwaite
- Hijmans
- Hooda
- Jackson
- James M. Bullock
- Jarvie
- Jarvie
- Jenkins
- John W. Redhead
- Johnes
- Johnes
- Keeler
- Keller
- Koerselman
- Leh
- Lena
- Linda May
- Maes
- Malinga
- MartĂnez-Harms
- May
- May
- McGuckin
- Meals
- Moore
- Morris
- Morton
- Naden
- Nedwell
- Nelson
- Newham
- Newham
- Pandeya
- Parn
- Perrine Hamel
- Perry
- Pessacg
- Quilbé
- Redhead
- Richard Sharp
- Richards
- Saunders
- Schulp
- Seppelt
- Sharp
- Sharp
- Sharps
- Shepherd
- Shi
- Smith
- SĂĄnchez-Canales
- Tague
- Tallis
- Tanguy
- Terrado
- Tom H. Oliver
- Vigerstol
- Villa
- Wilby
- Willcock
- Williams
- Withers
- Withers
- Publication venue
- 'Elsevier BV'
- Publication date
- 19/08/2017
- Field of study
A wide variety of tools aim to support decision making by modelling, mapping and quantifying ecosystem services. If decisions are to be properly informed, the accuracy and potential limitations of these tools must be well understood. However, dedicated studies evaluating ecosystem service models against empirical data are rare, especially over large areas. In this paper, we report on the national-scale assessment of a new ecosystem service model for nutrient delivery and retention, the InVEST Nutrient Delivery Ratio model. For 36 river catchments across the UK, we modelled total catchment export of phosphorus (P) and/or nitrogen (N) and compared model outputs to measurements derived from empirical water chemistry data.
The model performed well in terms of relative magnitude of nutrient export among catchments (best Spearmanâs rank correlation for N and P, respectively: 0.81 and 0.88). However, there was wide variation among catchments in the accuracy of the model, and absolute values of nutrient exports frequently showed high percentage differences between modelled and empirically-derived exports (best median absolute percentage difference for N and P, respectively: ± 64%, ± 44%). The model also showed a high degree of sensitivity to nutrient loads and hydrologic routing input parameters and these sensitivities varied among catchments.
These results suggest that the InVEST model can provide valuable information on nutrient fluxes to decision makers, especially in terms of relative differences among catchments. However, caution is needed if using the absolute modelled values for decision-making. Our study also suggests particular attention should be paid to researching input nutrient loadings and retentions, and the selection of appropriate input data resolutions and threshold flow accumulation values. Our results also highlight how availability of empirical data can improve model calibration and performance assessment and reinforce the need to include such data in ecosystem service modelling studies
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
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- Bauchmuller K
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- Belda MT
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- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
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- Berg A
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- Bertram W
- Bester D
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- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
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- Biais M
- Biccard BM
- Bidd H
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- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
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- Bodansky D
- Bodger P
- Boer C
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- Boggiano V
- Bogner G
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- Boshier P
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- Bouwman A
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- Bradley J
- Branagan G
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- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
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- Brincat M
- Briscoe R
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- Brooke J
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- Chandrasekharan S
- Chang YH
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- Chin II
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- Chisbert Cuenca V
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- Choi H-MD
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- Christodoulidis G
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- Christofaki M
- Christoforidis D
- Chronis C
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- de Swardt M
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- de Villiers M
- de Wet J
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- Delgado Garcia DR
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- Dudson R
- Duenser M
- Dumitrascu CO
- Dumitrescu A
- Dunay A
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- Eichwalder A
- Eikman J
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- Faponle F
- Faria e Maia D
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- Farina Z
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- Fasina O
- Fatungase OM
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- ISOS ISOS
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Introduction of the Uppsala Traumatic Brain Injury register for regular surveillance of patient characteristics and neurointensive care management including secondary insult quantification and clinical outcome
- Author
- Afessa B
- Anders Lewén
- Bhatia A
- Biersteker H
- Bullock MR
- Chambers IR
- Citerio G
- Davis DP
- Eker C
- Elf K
- Emanuelson I
- Heskestad B
- Howells T
- Jennett B
- Kim YJ
- Koskinen S
- Lena Nyholm
- Maas A
- Majdan M
- Marshall L
- Naredi S
- Olivecrona M
- Olivecrona M
- Per Enblad
- Pettigrew L
- Piper I
- Rusnak M
- Ryttlefors M
- Starmark JE
- Teasdale G
- Tim Howells
- Wilson JT
- Zhu C
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Mapping the human genetic architecture of COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3â7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Extending Photoinduced Charge Separation Lifetimes by Using Supramolecular Design: GuanineâPerylenediimide G-Quadruplex
- Author
- Bakulin A. A.
- Baumann A.
- Brown K. E.
- Bullock J. E.
- Bullock J. E.
- Cauët E.
- Chinnapen D. J.-F.
- Chiorcea-Paquim A.-M.
- Choi J.
- Coakley K. M.
- Conwell E. M.
- Davis J. T.
- Davis J. T.
- Ferreira K. N.
- Frischmann P. D.
- Genereux J. C.
- Gonnelli A.
- GonzĂĄlez-RodrĂguez D.
- GonzĂĄlez-RodrĂguez D.
- Graziano C.
- Guinier A.
- Guldi D. M.
- Gust D.
- GĂŒnes S.
- Hanwell M. D.
- Hoeben F. J. M.
- Holten D.
- Jerschow A.
- Jerschow A.
- Kristen E. Brown
- Laschat S.
- Lena S.
- Lewis F. D.
- Lewis F. D.
- Lindner S. M.
- Mariani P.
- Mariani P.
- MartiÄ S.
- Masiero S.
- Masiero S.
- McDermott G.
- Michael R. Wasielewski
- Okamoto A.
- PaleÄek E.
- Rybtchinski B.
- Schmidt-Mende L.
- Seidel C. A. M.
- Spada G. P.
- Spano F. C.
- Svergun D. I.
- Tauber M. J.
- van der Boom T.
- van Duren J. K. J.
- Warman J. M.
- Wasielewski M. R.
- Wasielewski M. R.
- Wasielewski M. R.
- Yi-Lin Wu
- Yoshioka Y.
- Zeidan T. A.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
MiR-21 Expression in the Tumor Stroma of Oral Squamous Cell Carcinoma: An Independent Biomarker of Disease Free Survival
- Author
- Anne-Marie K. Fiehn
- B Nielsen
- BS Nielsen
- C Lajer
- C Thode
- Christian von Buchwald
- D Marsh
- D Sayed
- David H. Jensen
- E Dabelsteen
- Erik Dabelsteen
- HE van Beurden
- J Li
- Jörg D. Hoheisel
- K Hase
- L Rask
- LB Frankel
- Lena Specht
- Lennart Friis-Hansen
- LF Sempere
- LX Yan
- M Dillhoff
- M Fassan
- M Vered
- M Yamashita
- Marianne H. Therkildsen
- MD Bullock
- MG Kellermann
- N Yamamichi
- NK Cervigne
- Nora HedbÀck
- Q Yao
- R Kalluri
- S Roy
- S Zhu
- SK Hermansen
- Y Hiyoshi
- Y Wang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Models of the bilingual lexicon and their theoretical implications for CLIL
- Author
- Albert R.
- Bazerman C.
- Boroditsky L.
- Breidbach S.
- Breidbach S.
- Bullock Report
- Corson D.
- Costa A.
- Coyle D.
- Cummins J
- Cummins J.
- Dalton-Puffer C.
- Dalton-Puffer C.
- De Bot K.
- DGFG
- Doff S.
- Grosjean F.
- Hallet W.
- Harwood N.
- Heine L.
- Herdina P.
- Hyland K.
- Jessner U.
- LaupenmĂŒhlen J.
- Lena Heine
- Parchmann I.
- Pavlenko A.
- Pavlenko A.
- Pressley M.
- Schreiber W.
- Vollmer H.J.
- Vosniadou S.
- Weiglhofer H.
- Weinreich U.
- ZydatiĂ W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
BRAF V600E-specific immunohistochemistry reveals low mutation rates in biliary tract cancer and restriction to intrahepatic cholangiocarcinoma
- Author
- A Hauschild
- A Skorokhod
- A Tannapfel
- AA Saetta
- AF Hezel
- Albrecht Stenzinger
- Andreas von Deimling
- Arianeb Mehrabi
- Arne Warth
- B Blechacz
- Benjamin Goeppert
- C Koelsche
- C Michaloglou
- CW Toon
- D Capper
- D Capper
- D Goldenberg
- D Sia
- David Capper
- DR Borger
- E Colomba
- Frederick Klauschen
- G Gentilcore
- G Schindler
- GS Falchook
- GV Long
- GV Long
- GV Long
- H Davies
- HT Arkenau
- J Lade-Keller
- JB Andersen
- JS Voss
- K Kim
- Katja Boehmer
- KJ Busam
- KT Flaherty
- Lena Frauenschuh
- M Andrulis
- M Andrulis
- M Bullock
- M Ilie
- M Xing
- Marcus Renner
- Mohammadreza Hafezi
- Monika Nadja Vogel
- O Koperek
- PB Chapman
- Peter Schirmacher
- S Dietrich
- S Rush
- Stephanie Roessler
- Wilko Weichert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Carbamate Derivatives of Indolines as Cholinesterase Inhibitors and Antioxidants for the Treatment of Alzheimerâs Disease
- Author
- Abraham Nudelman
- Allegra M.
- Andrey Zaikin
- Arriagada P. V.
- Bullock R.
- Butterfield D. A.
- Buxser S. E.
- Chyan Y. J.
- Coyle J. T.
- Darvesh S.
- Desagher S.
- Dong L.
- Efrat Finkin-Groner
- Ellman G. L.
- Farlow M.
- Farlow M.
- Feldkamp T.
- Feldman H.
- Ferris S.
- Georgiades S. N.
- Giacobini E.
- Ginsburg I.
- Ginsburg I.
- Green J. W. S.
- Greig N. H.
- Gribble G. W.
- Groner E.
- Halliwell B.
- Halliwell B.
- Harasimowicz J.
- Harel M.
- Hescheler J.
- Hila Shalom
- Inessa Yanovsky
- Inestrosa N. C.
- Isaac Ginsburg
- Kojima T.
- Koren E.
- Lee S. B.
- Lena Lerman
- Lieven C. J.
- Marta Weinstock
- Maruyama W.
- Mesulam M.
- Montagne C.
- Narita M.
- Nishizawa T.
- Nunomura A.
- Papageorgiou G. C.
- Perry G.
- Shani Zeeli
- Silva N. M.
- Sinhababu A. K.
- Smith G.
- Smith M. A.
- Sterling J.
- Sterling J.
- Su B.
- Sussman J. L.
- Tan D. X.
- Tehilla Weill
- Weinstock M.
- Wells G. J.
- Woollacott A. J.
- Xue F. T.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study