Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo

A class of recessive lethal zebrafish mutations has been identified in which normal skeletal muscle differentiation is followed by a tissue-specific degeneration that is reminiscent of the human muscular dystrophies. Here, we show that one of these mutations, sapje, disrupts the zebrafish orthologue of the X-linked human Duchenne muscular dystrophy (DMD) gene. Mutations in this locus cause Duchenne or Becker muscular dystrophies in human patients and are thought to result in a dystrophic pathology through disconnecting the cytoskeleton from the extracellular matrix in skeletal muscle by reducing the level of dystrophin protein at the sarcolemma. This is thought to allow tearing of this membrane, which in turn leads to cell death. Surprisingly, we have found that the progressive muscle degeneration phenotype of sapje mutant zebrafish embryos is caused by the failure of embryonic muscle end attachments. Although a role for dystrophin in maintaining vertebrate myotendinous junctions (MTJs) has been postulated previously and MTJ structural abnormalities have been identified in the Dystrophin-deficient mdx mouse model, in vivo evidence of pathology based on muscle attachment failure has thus far been lacking. This zebrafish mutation may therefore provide a model for a novel pathological mechanism of Duchenne muscular dystrophy and other muscle diseases

Limiting Behaviour of the Mean Residual Life

In survival or reliability studies, the mean residual life or life expectancy is an important characteristic of the model. Here, we study the limiting behaviour of the mean residual life, and derive an asymptotic expansion which can be used to obtain a good approximation for large values of the time variable. The asymptotic expansion is valid for a quite general class of failure rate distributions--perhaps the largest class that can be expected given that the terms depend only on the failure rate and its derivatives.Comment: 19 page

A transiting companion to the eclipsing binary KIC002856960

We present an early result from an automated search of Kepler eclipsing binary systems for circumbinary companions. An intriguing tertiary signal has been discovered in the short period eclipsing binary KIC002856960. This third body leads to transit-like features in the light curve occurring every 204.2 days, while the two other components of the system display eclipses on a 6.2 hour period. The variations due to the tertiary body last for a duration of \sim1.26 days, or 4.9 binary orbital periods. During each crossing of the binary orbit with the tertiary body, multiple individual transits are observed as the close binary stars repeatedly move in and out of alignment with the tertiary object. We are at this stage unable to distinguish between a planetary companion to a close eclipsing binary, or a hierarchical triply eclipsing system of three stars. Both possibilities are explored, and the light curves presented.Comment: Accepted into A&A Letters (5 pages & 3 figures

Computational information geometry in statistics: foundations

This paper lays the foundations for a new framework for numerically and computationally applying information geometric methods to statistical modelling

Interferometric Observatories in Earth Orbit

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76217/1/AIAA-1728-623.pd

Detection of gravity modes in the massive binary V380 Cyg from Kepler spacebased photometry and high-resolution spectroscopy

We report the discovery of low-amplitude gravity-mode oscillations in the massive binary star V380 Cyg, from 180 d of Kepler custom-aperture space photometry and 5 months of high-resolution high signal-to-noise spectroscopy. The new data are of unprecedented quality and allowed to improve the orbital and fundamental parameters for this binary. The orbital solution was subtracted from the photometric data and led to the detection of periodic intrinsic variability with frequencies of which some are multiples of the orbital frequency and others are not. Spectral disentangling allowed the detection of line-profile variability in the primary. With our discovery of intrinsic variability interpreted as gravity mode oscillations, V380 Cyg becomes an important laboratory for future seismic tuning of the near-core physics in massive B-type stars.Comment: 5 pages, 4 figures, 2 tables. Accepted for publication in MNRAS Letter

Photon storage in Lambda-type optically dense atomic media. I. Cavity model

In a recent paper [Gorshkov et al., Phys. Rev. Lett. 98, 123601 (2007)], we used a universal physical picture to optimize and demonstrate equivalence between a wide range of techniques for storage and retrieval of photon wave packets in Lambda-type atomic media in free space, including the adiabatic reduction of the photon group velocity, pulse-propagation control via off-resonant Raman techniques, and photon-echo-based techniques. In the present paper, we perform the same analysis for the cavity model. In particular, we show that the retrieval efficiency is equal to C/(1+C) independent of the retrieval technique, where C is the cooperativity parameter. We also derive the optimal strategy for storage and, in particular, demonstrate that at any detuning one can store, with the optimal efficiency of C/(1+C), any smooth input mode satisfying T C gamma >> 1 and a certain class of resonant input modes satisfying T C gamma ~ 1, where T is the duration of the input mode and 2 gamma is the transition linewidth. In the two subsequent papers of the series, we present the full analysis of the free-space model and discuss the effects of inhomogeneous broadening on photon storage.Comment: 16 pages, 2 figures. V2: significant changes in presentation, new references, higher resolution of figure

The Ames Virtual Environment Workstation: Implementation issues and requirements

This presentation describes recent developments in the implementation of a virtual environment workstation in the Aerospace Human Factors Research Division of NASA's Ames Research Center. Introductory discussions are presented on the primary research objectives and applications of the system and on the system's current hardware and software configuration. Principle attention is then focused on unique issues and problems encountered in the workstation's development with emphasis on its ability to meet original design specifications for computational graphics performance and for associated human factors requirements necessary to provide compelling sense of presence and efficient interaction in the virtual environment

Photon storage in Lambda-type optically dense atomic media. II. Free-space model

In a recent paper [Gorshkov et al., Phys. Rev. Lett. 98, 123601 (2007)], we presented a universal physical picture for describing a wide range of techniques for storage and retrieval of photon wave packets in Lambda-type atomic media in free space, including the adiabatic reduction of the photon group velocity, pulse-propagation control via off-resonant Raman techniques, and photon-echo based techniques. This universal picture produced an optimal control strategy for photon storage and retrieval applicable to all approaches and yielded identical maximum efficiencies for all of them. In the present paper, we present the full details of this analysis as well some of its extensions, including the discussion of the effects of non-degeneracy of the two lower levels of the Lambda system. The analysis in the present paper is based on the intuition obtained from the study of photon storage in the cavity model in the preceding paper [Gorshkov et al., Phys. Rev. A 76, 033804 (2007)].Comment: 26 pages, 8 figures. V2: significant changes in presentation, new references, higher resolution of figure

Dynamical masses, absolute radii and 3D orbits of the triply eclipsing star HD 181068 from Kepler photometry

HD 181068 is the brighter of the two known triply eclipsing hierarchical triple stars in the Kepler field. It has been continuously observed for more than 2 yr with the Kepler space telescope. Of the nine quarters of the data, three have been obtained in short-cadence mode, that is one point per 58.9 s. Here we analyse this unique data set to determine absolute physical parameters (most importantly the masses and radii) and full orbital configuration using a sophisticated novel approach. We measure eclipse timing variations (ETVs), which are then combined with the single-lined radial velocity measurements to yield masses in a manner equivalent to double-lined spectroscopic binaries. We have also developed a new light-curve synthesis code that is used to model the triple, mutual eclipses and the effects of the changing tidal field on the stellar surface and the relativistic Doppler beaming. By combining the stellar masses from the ETV study with the simultaneous light-curve analysis we determine the absolute radii of the three stars. Our results indicate that the close and the wide subsystems revolve in almost exactly coplanar and prograde orbits. The newly determined parameters draw a consistent picture of the system with such details that have been beyond reach before