1983 Fall Field Day

There were 55 who registered for the 1983 Fall Field Day, 24/25 September 1983, at the 4-H Camp at Halsey National Forest. With the benefit of good weather they tallied 94 species on or near the Forest, and a party that went up US 83 as far as the North Loup added 10 more (marked [N]), and 2 or 3 unidentified species of shore birds. The Scott\u27s Oriole, near Wauneta, was selected as the best of the birds submitted for consideration, with the Black-necked Stilt, near Gothenburg, and the Glossy Ibis, at Lincoln, tied for second. After the slide show Saturday night (which included an identification quiz) Wayne J. Mollhoff, of Albion, spoke about the Holartic Avian Speciation Atlas, for which he is the Nebraska coordinator, soliciting the support of NOU as an organization, and the members as individuals. He proposes about 400 blocks, each about 3 miles square, which will be surveyed for evidence of breeding of the species actually or expected to be found there. Collection of the data is expected to be done from 1984 to 1988

Diagnóstico e tratamento da drepanocitose: novas metodologias

A hemoglobina é a molécula constituinte dos glóbulos vermelhos, responsável pelo transporte de oxigénio para todo o corpo. Mutações nos genes desta molécula podem resultar em alterações na sua síntese a nível quantitativo ou estrutural, afetando a sua normal função e desencadeando as hemoglobinopatias. Dentro das hemoglobinopatias existem as doenças falciformes que se particularizam pela presença obrigatória da variante hemoglobina S (Hb S). A drepanocitose, tipo de doença falciforme mais grave e incapacitante, é uma doença genética hereditária com transmissão autossómica recessiva. Caracteriza-se pela sua cronicidade, marcada por anemia e hemólise, aumentando a suscetibilidade a infeções e ao surgimento de crises vaso-oclusivas. Atualmente, é notório um crescente interesse na procura de novas terapêuticas para o tratamento deste tipo de doenças. As principais apostas a nível terapêutico recaem sobre a hidroxiureia, transfusões sanguíneas, transplante alogénico de células estaminais hematopoiéticas e a terapia genética. Porém, tendo em conta a gravidade da doença e a insuficiência relativamente às opções terapêuticas curativas, o rastreio e diagnóstico atempados constituem ferramentas valiosas para a prevenção e atuação precoce com o intuito de reduzir complicações clínicas resultantes da drepanocitose. Com a presente dissertação de mestrado pretende-se reunir, através de uma revisão bibliográfica, a mais recente evidência científica sobre a drepanocitose e as novas metodologias de diagnóstico e tratamento. A terapia genética surge como uma abordagem terapêutica promissora que já demonstrou colmatar as limitações terapêuticas anteriormente instituídas. Não obstante, terá de ser demonstrada a sua eficácia e segurança a longo prazo para se tornar no tratamento de eleição para a drepanocitose.Hemoglobin is the constituent molecule of red blood cells, responsible for transporting oxygen throughout the body. Mutations in the genes of this molecule can result in alterations in its synthesis at a quantitative or structural level, affecting its normal function and triggering hemoglobinopathies. Among the hemoglobinopathies are sickle cell diseases, which are characterized by the obligatory presence of variant hemoglobin S (Hb S). Sickle cell disease, the most serious and disabling type of sickle cell disease, is an inherited genetic disease with autosomal recessive transmission. It is characterized by its chronicity, marked by anemia and hemolysis, increasing susceptibility to infections and the onset of vaso-occlusive crises. Currently, there is a growing interest in the search for new therapies for the treatment of this type of disease. The main therapeutic options are hydroxyurea, blood transfusions, allogeneic hematopoietic stem cell transplantation and gene therapy. However, considering the severity of the disease and the insufficiency of curative therapeutic options, timely screening and diagnosis are valuable tools for prevention and early action to reduce clinical complications resulting from sickle cell disease. This master's thesis aims to gather, through a literature review, the most recent scientific evidence on sickle-cell disease and new diagnostic and treatment methodologies. Gene therapy emerges as a promising therapeutic approach that has been shown to overcome previously established therapeutic limitations. Nevertheless, its long-term efficacy and safety will have to be demonstrated to become the treatment of choice for sickle cell disease

Visualización y análisis mediante series temporales de la siniestralidad vial del Uruguay en el período 2013 - 2017

En el período 2013 – 2017 hubo 326.464 siniestros de tránsito, en los cuales resultaron 124.723 heridos leves, 19.134 heridos graves y 2527 fallecidos. Debido a la magnitud que alcanza esta problemática en Uruguay, se ha llevado a cabo durante los últimos años la implementación de nuevas leyes, medidas y campañas de concientización con el fin de mejorar la seguridad vial. La UNASEV (Unidad Nacional de Seguridad Vial) publica regularmente datos nacionales sobre siniestralidad. En base a estos datos es que se presenta el análisis de aquellos siniestros en los que los afectados resultaron lesionados sin llegarse a constatar el fallecimiento dado el gran impacto social y económico que esto genera al país. El presente trabajo tiene como objetivo la descripción de la siniestralidad vial en el Uruguay para el período 2013-2017 utilizando el análisis de la serie temporal. Se busca generar herramientas estadísticas que permitan estudiar el impacto de las diversas campañas de prevención realizadas en el período de estudio así como generar un modelo de predicción para los años venideros. Se utilizan los paquetes shiny y dygraph para generar una aplicación interactiva que permite explorar la serie y el problema en más detalle, generando una nueva perspectiva de los datos. La presentación está dirigida a usuarios de R interesados en el análisis de series temporales y en la visualización interactiva de datos así como a aquellas personas que estén interesadas en la temática de la siniestralidad vial.Sociedad Argentina de Informática e Investigación Operativ

Visualización y análisis mediante series temporales de la siniestralidad vial del Uruguay en el período 2013 - 2017

En el período 2013 – 2017 hubo 326.464 siniestros de tránsito, en los cuales resultaron 124.723 heridos leves, 19.134 heridos graves y 2527 fallecidos. Debido a la magnitud que alcanza esta problemática en Uruguay, se ha llevado a cabo durante los últimos años la implementación de nuevas leyes, medidas y campañas de concientización con el fin de mejorar la seguridad vial. La UNASEV (Unidad Nacional de Seguridad Vial) publica regularmente datos nacionales sobre siniestralidad. En base a estos datos es que se presenta el análisis de aquellos siniestros en los que los afectados resultaron lesionados sin llegarse a constatar el fallecimiento dado el gran impacto social y económico que esto genera al país. El presente trabajo tiene como objetivo la descripción de la siniestralidad vial en el Uruguay para el período 2013-2017 utilizando el análisis de la serie temporal. Se busca generar herramientas estadísticas que permitan estudiar el impacto de las diversas campañas de prevención realizadas en el período de estudio así como generar un modelo de predicción para los años venideros. Se utilizan los paquetes shiny y dygraph para generar una aplicación interactiva que permite explorar la serie y el problema en más detalle, generando una nueva perspectiva de los datos. La presentación está dirigida a usuarios de R interesados en el análisis de series temporales y en la visualización interactiva de datos así como a aquellas personas que estén interesadas en la temática de la siniestralidad vial.Sociedad Argentina de Informática e Investigación Operativ

Visualización y análisis mediante series temporales de la siniestralidad vial del Uruguay en el período 2013 - 2017

En el período 2013 – 2017 hubo 326.464 siniestros de tránsito, en los cuales resultaron 124.723 heridos leves, 19.134 heridos graves y 2527 fallecidos. Debido a la magnitud que alcanza esta problemática en Uruguay, se ha llevado a cabo durante los últimos años la implementación de nuevas leyes, medidas y campañas de concientización con el fin de mejorar la seguridad vial. La UNASEV (Unidad Nacional de Seguridad Vial) publica regularmente datos nacionales sobre siniestralidad. En base a estos datos es que se presenta el análisis de aquellos siniestros en los que los afectados resultaron lesionados sin llegarse a constatar el fallecimiento dado el gran impacto social y económico que esto genera al país. El presente trabajo tiene como objetivo la descripción de la siniestralidad vial en el Uruguay para el período 2013-2017 utilizando el análisis de la serie temporal. Se busca generar herramientas estadísticas que permitan estudiar el impacto de las diversas campañas de prevención realizadas en el período de estudio así como generar un modelo de predicción para los años venideros. Se utilizan los paquetes shiny y dygraph para generar una aplicación interactiva que permite explorar la serie y el problema en más detalle, generando una nueva perspectiva de los datos. La presentación está dirigida a usuarios de R interesados en el análisis de series temporales y en la visualización interactiva de datos así como a aquellas personas que estén interesadas en la temática de la siniestralidad vial.Sociedad Argentina de Informática e Investigación Operativ

Le parc urbain des papillons : un dispositif collaboratif de recherche, formation et diffusion des connaissances sur la biodiversité urbaine

Dans les zones urbaines du monde entier, les scientifiques ont observé l’homogénéisation de la biodiversité. De plus, l’urbanisation et les modes de vie modernes ont considérablement réduit les connaissances et les interactions de l’homme avec la nature. Ces deux phénomènes ont de graves conséquences pour la conservation de la biodiversité. Dans cet article, nous présentons la conception et la mise en œuvre, par un large éventail d’acteurs, d’un dispositif expérimental de recherche et de sensibilisation sur la biodiversité urbaine, le Parc Urbain des Papillons (PUP). L’élaboration collaborative de ce dispositif associe, d’une part, la recherche expérimentale pour repenser les pratiques de gestion des parcs urbains afin de favoriser le maintien voire la reconquête de la biodiversité dans les espaces urbains et, d’autre part, la formation participative, la médiation et les échanges avec un public diversifié (gestionnaires de l’environnement, étudiants, scolaires et grand public). L’intérêt de ce dispositif réside dans l’aspect collaboratif, permettant un enrichissement par échanges d’expériences entre les différents acteurs et les publics. Pour conclure, le PUP offre de nombreuses opportunités de partager et d’échanger différemment dans le domaine des sciences du vivant et de développer des programmes d’apprentissage, de formation et de sensibilisation largement négligés en milieu urbain.Throughout the world, in urban areas, scientists have observed the homogenization of the biodiversity. Furthermore, urbanization and modern lifestyles have greatly reduced people's knowledge of and interaction with nature. Both have grave consequences for the conservation of the biodiversity. Here, we present the construction and the implementation, by a wide range of actors, of a park focused on urban biodiversity, the Parc Urbain des Papillons (PUP). The collaborative construction of this park associates, on one hand, experimental research on rethinking management practices to encourage the reestablishment of biodiversity in the city and, on the other hand, active training, mediation and exchanges for a range of publics (environment managers, students, schoolchildren and the general public). The interest of this kind of programme lies in the collaborative aspect, allowing considerable enrichment through the exchange of experiences between the various actors and publics. We conclude by pointing out that this experimental park provides extensive opportunities for sharing science differently and for developing learning, training and outreach programmes overlooked in urban areas

Candida albicans quorum-sensing molecule farnesol modulates staphyloxanthin production and activates the thiol-based oxidative-stress response in Staphylococcus aureus

Microbial species utilize secreted-signaling molecules to coordinate their behavior. Our previous investigations demonstrated a key role for the Candida albicans-secreted quorum-sensing molecule farnesol in modulating Staphylococcus aureus response to antimicrobials in mixed biofilms. In this study, we aimed to provide mechanistic insights into the impact of farnesol on S. aureus within the context of inter-species interactions. To mimic biofilm dynamics, farnesol-sensitized S. aureus cells were generated via sequential farnesol exposure. The sensitized phenotype exhibited dramatic loss of the typical pigment, which we identified as staphyloxanthin, an important virulence factor synthesized by the Crt operon in S. aureus. Additionally, farnesol exposure exerted oxidative-stress as indicated by transcriptional analysis demonstrating alterations in redox-sensors and major virulence regulators. Paradoxically, the activated stress-response conferred S. aureus with enhanced tolerance to H2O2 and phagocytic killing. Since expression of enzymes in the staphyloxanthin biosynthesis pathway was not impacted by farnesol, we generated a theoretical-binding model which indicated that farnesol may block staphyloxanthin biosynthesis via competitive-binding to the CrtM enzyme crucial for staphyloxanthin synthesis, due to high structural similarity to the CrtM substrate. Finally, mixed growth with C. albicans was found to similarly induce S. aureus depigmentation, but not during growth with a farnesol-deficient C. albicans strain. Collectively, the findings demonstrate that a fungal molecule acts as a redox-cycler eliciting a bacterial stress response via activation of the thiol-based redox system under the control of global regulators. Therefore, farnesol-induced transcriptional modulations of key regulatory networks in S. aureus may modulate the pathogenesis of C. albicans- S. aureus co-infections

Demagnetizing field-induced magnetocaloric effect in Gd

We have studied the impact of demagnetizing fields on the magnetocaloric effect of commercial-grade gadolinium plates. Adiabatic temperature changes (⁠ ⁠) were measured for magnetic fields applied along the parallel and perpendicular directions of the plates. The differences in the obtained values were accounted for by differences in the internal field due to demagnetizing effects. A combination of calorimetric measurements under a magnetic field and thermometric measurements has enabled us to obtain Brayton cycles for the two different magnetic field orientations. It has been found that the refrigerant capacity for a Brayton cycle working at 1.6 T around room temperature reduces from to  J kg when the demagnetizing factor changes from  = 0.035 to for the parallel and perpendicular configurations, respectively. It has been shown that it is possible to obtain significant demagnetizing field-induced magnetocaloric effects by rotating the sample in a region of a constant applied magnetic field. The refrigerant capacity of a Brayton cycle around room temperature for a T constant applied magnetic field is  J kg ⁠. The feasibility of these demagnetizing field-induced effects has been confirmed by direct thermometric measurements, which reveal adiabatic temperature changes of 1 K when the sample is rotated between the perpendicular and parallel configurations

Measurement of tt̅ spin correlation in pp̅ collisions using the CDF II detector at the Tevatron

7 páginas, 2 figuras, 1 tabla.-- PACS numbers: 12.38.Qk, 13.85.-t, 14.65.Ha.-- CDF Collaboration: et al.The tt̅ spin correlation at production is a fundamental prediction of QCD and a potentially incisive test of new physics coupled to top quarks. We measure the tt̅ spin state in pp̅ collisions at √s=1.96  TeV using 1001 candidate events in the lepton plus jets decay channel reconstructed in the CDF II detector. In the helicity basis, for a top-quark mass of 172.5  GeV/c2, we find a spin correlation coefficient κ=0.60±0.50  (stat)±0.16  (syst), consistent with the QCD prediction, κ≈0.40.This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A. P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, UK; the Institut National de Physique Nucleaire et Physique des Particules/CNRS; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak R & D Agency; and the Academy of Finland.Peer reviewe