Factors Affecting the Longevity of Individual Terrorists

The purpose of this study is to examine factors that affect the longevity of individual terrorists. Previous studies on terrorist group longevity have focused on the decisions terrorist groups have made rather than focusing on factors that help individuals evade capture. Literature also suggests that terrorists that manage to stay active may be able to use this as a valuable recruiting tool. This project examines six different relationships with longevity, including Attorney General (AG) Guidelines, demographics, ideology, level of participation, number of activities, and sophistication of attack. To examine these relationships, data will be used from the American Terrorism Study (ATS) to conduct bivariate analysis. The results support most of the exploratory hypotheses presented. This project will conclude by proposing possible avenues for future research

The Longevity of American Terrorists: Factors Affecting Sustainability

This project was an outgrowth of two previous NIJ projects being conducted under NIJ’s Research and Evaluation on Domestic Radicalization to Violent Extremism program area. The first of these projects, which ended in 2015, focused upon testing one of the most prominent theoretical models of extremist radicalization -- identity and framing theory. One of the findings from examination of this theoretical model is consistent with the notion that “people want to be associated with a winner.” Recruitment and commitment, crucial to the lifespan of any terrorist movement, improve when the movement has been able to commit successful terrorist incidents (Freilich, Chermak, and Caspi, 2009), particularly if the offenders escaped unscathed. In the second project, which focused upon the temporal sequencing of terrorists’ precursor behaviors,2 a somewhat serendipitous finding emerged to crystalize the current issue. A preliminary analysis of the differences between “lone actors” and members of “cells or groups” revealed that lone actors “survived” substantially longer than members of cells or groups before being arrested or indicted. Although we later found this relationship to be spurious, it was worthy of further examination

City of Hitchcock Comprehensive Plan 2020-2040

Hitchcock is a small town located in Galveston County (Figure 1.1), nestled up on the Texas Gulf Coast. It lies about 40 miles south-east of Houston. The boundaries of the city encloses an area of land of 60.46 sq. miles, an area of water of 31.64 sq. miles at an elevation just 16 feet above sea level. Hitchcock has more undeveloped land (~90% of total area) than the county combined. Its strategic location gives it a driving force of opportunities in the Houston-Galveston Region.The guiding principles for this planning process were Hitchcock’s vision statement and its corresponding goals, which were crafted by the task force. The goals focus on factors of growth and development including public participation, development considerations, transportation, community facilities, economic development, parks, and housing and social vulnerabilityTexas Target Communitie

Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR Review X

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Functional Outcome Measures of Recombinant Tissue Plasminogen Activator–Treated Stroke Patients in the Telestroke Technology

The efficiency of telestroke programs in improving the rates of recombinant tissue plasminogen activator (rtPA) in stroke patients has been reported. Previous studies have reported favorable treatment outcomes with the use of telestroke programs to improve the use of rtPA, but functional outcomes are not fully understood. This study investigated the effect of telestroke technology in the administration of rtPA and related functional outcomes associated with baseline clinical variables. Retrospective data of a telestroke registry were analyzed. Univariate analysis was used to compare demographic and clinical variables in the rtPA group and the no rtPA group and between the improved functional ambulation group and the no improvement group. A stepwise binary logistic regression identified factors associated with improved functional outcome in the total telestroke population and in the subset of the telestroke population who received rtPA. In adjusted analysis and elimination of any multicollinearity for patients who received rtPA in the telestroke setting, obesity (odds ratio [OR] = 2.138, 95% confidence interval [CI], 1.164-3.928, P  < .05), higher systolic blood pressure at the time of presentation (OR = 1.015, 95% CI, 1.003-1.027, P  < .05), and baseline high-density lipoprotein at the time of admission (OR = 1.032, 95% CI, 1.005-1.059, P  < .05) were associated with improved functional outcomes. Increasing age (OR = 0.940, 95% CI, 0.916-0.965, P  < .0001) and higher calculated National Institutes of Health Stroke Scale (OR = 0.903, 95% CI, 0.869-0.937) were associated with a poorer outcome in rtPA-treated patients. Telestroke technology improves functional outcomes at spoke stations where neurological expertise is unavailable. Further studies are necessary to determine how telestroke technology can be optimized, especially to improve contraindications and increase eligibility for thrombolysis therapy

Vieillesse et pouvoir

Si Charlemagne est connu pour avoir atteint la vieillesse, il n’est pas une exception parmi celles et ceux qui exercent le pouvoir au Moyen Âge. Médiévales cerne les rapports, dans le discours comme dans la pratique, entre vieillesse et pouvoir. Si la vieillesse est une réalité au Moyen Âge, elle n'en est pas moins une notion relative. Médiévales s’interroge sur ses contours (flous) et ce qui permet de considérer qu'une partie des détenteurs et détentrices du pouvoir l'ont atteint. Les auteurs analysent dans ce cadre les parcours individuels et les pratiques qui conduisent à l'exercice du pouvoir à un âge avancé, ses conséquences pour celui ou celle qui détient le pouvoir ou y participe, mais aussi pour les autres (entourage, individus relevant de son autorité) et donc les tensions intergénérationnelles qui peuvent en résulter, ainsi que le discours, admiratif, réprobateur ou indifférent, suscité par de telles situations

Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.Wellcom

Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR Review X.

Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.Wellcom