Application of High-precision Timing Systems to Distributed Survey Systems

In any hydrographic survey system that consists of more than one computer, one of the most difficult integration problems is to ensure that all components maintain a coherent sense of time. Since virtually all modern survey systems are of this type, timekeeping and synchronized timestamping of data as it is created is of significant concern. This paper describes a method for resolving this problem based on the IEEE 1588 Precise Time Protocol (PTP) implemented by hardware devices, layered with some custom software called the Software Grandmaster (SWGM) algorithm. This combination of hardware and software maintains a coherent sense of time between multiple ethernet-connected computers, on the order of 100 ns (rms) in the best case, of the timebase established by the local GPS-receiver clock. We illustrate the performance of this techniques in a practical survey system using a Reson 7P sonar processor connected to a Reson 7125 Multibeam Echosounder (MBES), integrated with an Applanix POS/MV 320 V4 and a conventional data capture computer. Using the timing capabilities of the PTP hardware implementations, we show that the timepieces achieve mean (hardware based) synchronization and timestamping within 100-150 ns (rms), and that the data created at the Reson 7P without hardware timestamps has a latency variability of 28 µs (rms) due to software constraints within the capture system. This compares to 288 ms (rms) using Reson’s standard hybrid hardware/software solution, and 13.6 ms (rms) using a conventional single-oscillator timestamping model

Electronic Chart of the Future: The Hampton Roads Project

ECDIS is evolving from a two-dimensional static display of chart-related data to a decision support system capable of providing real-time or forecast information. While there may not be consensus on how this will occur, it is clear that to do this, ENC data and the shipboard display environment must incorporate both depth and time in an intuitively understandable way. Currently, we have the ability to conduct high-density hydrographic surveys capable of producing ENCs with decimeter contour intervals or depth areas. Yet, our existing systems and specifications do not provide for a full utilization of this capability. Ideally, a mariner should be able to benefit from detailed hydrographic data, coupled with both forecast and real-time water levels, and presented in a variety of perspectives. With this information mariners will be able to plan and carry out transits with the benefit of precisely determined and easily perceived underkeel, overhead, and lateral clearances. This paper describes a Hampton Roads Demonstration Project to investigate the challenges and opportunities of developing the “Electronic Chart of the Future.” In particular, a three-phase demonstration project is being planned: 1. Compile test datasets from existing and new hydrographic surveys using advanced data processing and compilation procedures developed at the University of New Hampshire’s Center for Coastal and Ocean Mapping/Joint Hydrographic Center (CCOM/JHC); 2. Investigate innovative approaches being developed at the CCOM/JHC to produce an interactive time- and tide-aware navigation display, and to evaluate such a display on commercial and/or government vessels; 3. Integrate real-time/forecast water depth information and port information services transmitted via an AIS communications broadcast

Reviews

Charles Williams: The Third Inkling. Grevel Lindop. Reviewed by Scott McLaren. The Chapel of the Thorn: A Dramatic Poem. Charles Williams. Edited and Introduced by Sørina Higgins. Reviewed by Scott McLaren. Women and C.S. Lewis: What His Life and Literature Reveal For Today’s Culture. Carolyn Curtis and Mary Pomroy Key, eds. Reviewed by Rebekah Choat. Tolkien Among the Moderns. Edited by Ralph C. Wood. Reviewed by Andrew C. Stout. Tolkien. Raymond Edwards. Reviewed by Cait Coker. Children into Swans: Fairy Tales and the Pagan Imagination. Jan Beveridge. Reviewed by Brian Roberts. Trilby/The Crumb Fairy. Charles Nodier. Translated and adapted by Ruth Berman. Reviewed by Kelly Orazi. The Prince of the Aquamarines. Louise Cavalier Levesque. Trans. and with an afterword by Ruth Berman. Reviewed by Kelly Orazi. The Lessons of Nature in Mythology. Rachel S. McCoppin. Reviewed by Kristine Larsen. Hither Shore: Jahrbuch der Deutschen Tolkien Gesellschaft. Special issue: Nature and Landscape in Tolkien. Ed. Thomas Fornet-Ponse et al. Reviewed by Janet Brennan Croft. Seven: An Anglo-American Literary Review. Ed. Marjorie Lamp Mead. Reviewed by Janet Brennan Croft. Tolkien Studies: An Annual Scholarly Review. Ed. Michael D.C. Drout, Verlyn Flieger, and David Bratman. Reviewed by Janet Brennan Croft. The Skill of a Seeker: Rowling, Religion and Gen 9/11. Marilyn R. Pukkila. Reviewed by Emily Moniz Mirova. Light: C.S. Lewis\u27s First and Final Short Story. Charlie W. Starr. Reviewed by Melody Green. The Story of Kullervo. J.R.R. Tolkien. Edited and introduced by Verlyn Flieger. Reviewed by Mike Foster. The Victorian Approach to Modernism in the Fiction of Dorothy L. Sayers. Aoife Leahy. Reviewed by Joe R. Christopher. Reading Joss Whedon. Rhonda V. Wilcox, Tanya R. Cochran, Cynthea Masson, and David Lavery, eds. Reviewed by by Janet Brennan Croft

Consumer\u27s Guide to Regulatory Impact Analysis: Ten Tips for Being an Informed Policymaker

Regulatory impact analyses (RIAs) weigh the benefits of regulations against the burdens they impose and are invaluable tools for informing decision makers.We offer 10 tips for nonspecialist policymakers and interested stakeholders who will be reading RIAs as consumers. Core problem: Determine whether the RIA identifies the core problem (compelling public need) the regulation is intended to address. Alternatives: Look for an objective, policy-neutral evaluation of the relative merits of reasonable alternatives. Baseline: Check whether the RIA presents a reasonable “counterfactual” against which benefits and costs are measured. Increments: Evaluate whether totals and averages obscure relevant distinctions and trade-offs. Uncertainty: Recognize that all estimates involve uncertainty, and ask what effect key assumptions, data, and models have on those estimates. Transparency: Look for transparency and objectivity of analytical inputs. Benefits: Examine how projected benefits relate to stated objectives. Costs: Understand what costs are included. Distribution: Consider how benefits and costs are distributed. Symmetrical treatment: Ensure that benefits and costs are presented symmetrically

Consumer\u27s Guide to Regulatory Impact Analysis: Ten Tips for Being an Informed Policymaker

Regulatory impact analyses (RIAs) weigh the benefits of regulations against the burdens they impose and are invaluable tools for informing decision makers.We offer 10 tips for nonspecialist policymakers and interested stakeholders who will be reading RIAs as consumers. Core problem: Determine whether the RIA identifies the core problem (compelling public need) the regulation is intended to address. Alternatives: Look for an objective, policy-neutral evaluation of the relative merits of reasonable alternatives. Baseline: Check whether the RIA presents a reasonable “counterfactual” against which benefits and costs are measured. Increments: Evaluate whether totals and averages obscure relevant distinctions and trade-offs. Uncertainty: Recognize that all estimates involve uncertainty, and ask what effect key assumptions, data, and models have on those estimates. Transparency: Look for transparency and objectivity of analytical inputs. Benefits: Examine how projected benefits relate to stated objectives. Costs: Understand what costs are included. Distribution: Consider how benefits and costs are distributed. Symmetrical treatment: Ensure that benefits and costs are presented symmetrically

Open Science principles for accelerating trait-based science across the Tree of Life.

Synthesizing trait observations and knowledge across the Tree of Life remains a grand challenge for biodiversity science. Species traits are widely used in ecological and evolutionary science, and new data and methods have proliferated rapidly. Yet accessing and integrating disparate data sources remains a considerable challenge, slowing progress toward a global synthesis to integrate trait data across organisms. Trait science needs a vision for achieving global integration across all organisms. Here, we outline how the adoption of key Open Science principles-open data, open source and open methods-is transforming trait science, increasing transparency, democratizing access and accelerating global synthesis. To enhance widespread adoption of these principles, we introduce the Open Traits Network (OTN), a global, decentralized community welcoming all researchers and institutions pursuing the collaborative goal of standardizing and integrating trait data across organisms. We demonstrate how adherence to Open Science principles is key to the OTN community and outline five activities that can accelerate the synthesis of trait data across the Tree of Life, thereby facilitating rapid advances to address scientific inquiries and environmental issues. Lessons learned along the path to a global synthesis of trait data will provide a framework for addressing similarly complex data science and informatics challenges

A genome-wide scan for common alleles affecting risk for autism

Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10−8. When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10−8 threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C

Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.

Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the apoptotic threshold in a subset of patient-derived glioblastoma (GBM) cells. Mechanistic studies revealed that after attenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis. Consequently, targeting of EGFR-driven glucose metabolism in combination with pharmacological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft models. Notably, neither the degree of EGFR-signaling inhibition nor genetic analysis of EGFR was sufficient to predict sensitivity to this therapeutic combination. However, detection of rapid inhibitory effects on [18F]fluorodeoxyglucose uptake, assessed through noninvasive positron emission tomography, was an effective predictive biomarker of response in vivo. Together, these studies identify a crucial link among oncogene signaling, glucose metabolism, and cytoplasmic p53, which may potentially be exploited for combination therapy in GBM and possibly other malignancies