217 research outputs found
Multiscale magnetic underdense regions on the solar surface: Granular and Mesogranular scales
The Sun is a non-equilibrium dissipative system subjected to an energy flow
which originates in its core. Convective overshooting motions create
temperature and velocity structures which show a temporal and spatial
evolution. As a result, photospheric structures are generally considered to be
the direct manifestation of convective plasma motions. The plasma flows on the
photosphere govern the motion of single magnetic elements. These elements are
arranged in typical patterns which are observed as a variety of multiscale
magnetic patterns. High resolution magnetograms of quiet solar surface revealed
the presence of magnetic underdense regions in the solar photosphere, commonly
called voids, which may be considered a signature of the underlying convective
structure. The analysis of such patterns paves the way for the investigation of
all turbulent convective scales from granular to global. In order to address
the question of magnetic structures driven by turbulent convection at granular
and mesogranular scales we used a "voids" detection method. The computed voids
distribution shows an exponential behavior at scales between 2 and 10 Mm and
the absence of features at 5-10 Mm mesogranular scales. The absence of
preferred scales of organization in the 2-10 Mm range supports the multiscale
nature of flows on the solar surface and the absence of a mesogranular
convective scale
Civic identity, municipal governance and provincial newspapers: the Lincoln of Bernard Gilbert, poet, critic and âboosterâ, 1914
Competing orders in a magnetic field: spin and charge order in the cuprate superconductors
We describe two-dimensional quantum spin fluctuations in a superconducting
Abrikosov flux lattice induced by a magnetic field applied to a doped Mott
insulator. Complete numerical solutions of a self-consistent large N theory
provide detailed information on the phase diagram and on the spatial structure
of the dynamic spin spectrum. Our results apply to phases with and without
long-range spin density wave order and to the magnetic quantum critical point
separating these phases. We discuss the relationship of our results to a number
of recent neutron scattering measurements on the cuprate superconductors in the
presence of an applied field. We compute the pinning of static charge order by
the vortex cores in the `spin gap' phase where the spin order remains
dynamically fluctuating, and argue that these results apply to recent scanning
tunnelling microscopy (STM) measurements. We show that with a single typical
set of values for the coupling constants, our model describes the field
dependence of the elastic neutron scattering intensities, the absence of
satellite Bragg peaks associated with the vortex lattice in existing neutron
scattering observations, and the spatial extent of charge order in STM
observations. We mention implications of our theory for NMR experiments. We
also present a theoretical discussion of more exotic states that can be built
out of the spin and charge order parameters, including spin nematics and phases
with `exciton fractionalization'.Comment: 36 pages, 33 figures; for a popular introduction, see
http://onsager.physics.yale.edu/superflow.html; (v2) Added reference to new
work of Chen and Ting; (v3) reorganized presentation for improved clarity,
and added new appendix on microscopic origin; (v4) final published version
with minor change
Modeling the Subsurface Structure of Sunspots
While sunspots are easily observed at the solar surface, determining their
subsurface structure is not trivial. There are two main hypotheses for the
subsurface structure of sunspots: the monolithic model and the cluster model.
Local helioseismology is the only means by which we can investigate
subphotospheric structure. However, as current linear inversion techniques do
not yet allow helioseismology to probe the internal structure with sufficient
confidence to distinguish between the monolith and cluster models, the
development of physically realistic sunspot models are a priority for
helioseismologists. This is because they are not only important indicators of
the variety of physical effects that may influence helioseismic inferences in
active regions, but they also enable detailed assessments of the validity of
helioseismic interpretations through numerical forward modeling. In this paper,
we provide a critical review of the existing sunspot models and an overview of
numerical methods employed to model wave propagation through model sunspots. We
then carry out an helioseismic analysis of the sunspot in Active Region 9787
and address the serious inconsistencies uncovered by
\citeauthor{gizonetal2009}~(\citeyear{gizonetal2009,gizonetal2009a}). We find
that this sunspot is most probably associated with a shallow, positive
wave-speed perturbation (unlike the traditional two-layer model) and that
travel-time measurements are consistent with a horizontal outflow in the
surrounding moat.Comment: 73 pages, 19 figures, accepted by Solar Physic
Active Brownian Particles. From Individual to Collective Stochastic Dynamics
We review theoretical models of individual motility as well as collective
dynamics and pattern formation of active particles. We focus on simple models
of active dynamics with a particular emphasis on nonlinear and stochastic
dynamics of such self-propelled entities in the framework of statistical
mechanics. Examples of such active units in complex physico-chemical and
biological systems are chemically powered nano-rods, localized patterns in
reaction-diffusion system, motile cells or macroscopic animals. Based on the
description of individual motion of point-like active particles by stochastic
differential equations, we discuss different velocity-dependent friction
functions, the impact of various types of fluctuations and calculate
characteristic observables such as stationary velocity distributions or
diffusion coefficients. Finally, we consider not only the free and confined
individual active dynamics but also different types of interaction between
active particles. The resulting collective dynamical behavior of large
assemblies and aggregates of active units is discussed and an overview over
some recent results on spatiotemporal pattern formation in such systems is
given.Comment: 161 pages, Review, Eur Phys J Special-Topics, accepte
A systematic review examining the effects of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on biomarkers of inflammation and oxidative stress
Neuroprotective activity of ursodeoxycholic acid in CHMP2B Intron5 models of frontotemporal dementia
Frontotemporal dementia (FTD) is one of the most prevalent forms of early-onset dementia. It represents part of the FTD-Amyotrophic Lateral Sclerosis (ALS) spectrum, a continuum of genetically and pathologically overlapping disorders. FTD-causing mutations in CHMP2B, a gene encoding a core component of the heteromeric ESCRT-III Complex, lead to perturbed endosomal-lysosomal and autophagic trafficking with impaired proteostasis. While CHMP2B mutations are rare, dysfunctional endosomal-lysosomal signalling is common across the FTD-ALS spectrum. Using our established Drosophila and mammalian models of CHMP2BIntron5 induced FTD we demonstrate that the FDA-approved compound Ursodeoxycholic Acid (UDCA) conveys neuroprotection, downstream of endosomal-lysosomal dysfunction in both Drosophila and primary mammalian neurons. UDCA exhibited a dose dependent rescue of neuronal structure and function in Drosophila pan-neuronally expressing CHMP2BIntron5. Rescue of CHMP2BIntron5 dependent dendritic collapse and apoptosis with UDCA in rat primary neurons was also observed. UDCA failed to ameliorate aberrant accumulation of endosomal and autophagic organelles or ubiquitinated neuronal inclusions in both models. We demonstrate the neuroprotective activity of UDCA downstream of endosomal-lysosomal and autophagic dysfunction, delineating the molecular mode of action of UDCA and highlighting its potential as a therapeutic for the treatment of FTD-ALS spectrum disorders
The developmental activities of elite soccer players aged under-16 years from Brazil, England, France, Ghana, Mexico, Portugal and Sweden
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge
There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing genetic disease starting from clinical case history and genome sequencing data. DNA samples were obtained from three families with heritable genetic disorders and genomic sequence data were donated by sequencing platform vendors. The challenge was to analyze and interpret these data with the goals of identifying disease-causing variants and reporting the findings in a clinically useful format. Participating contestant groups were solicited broadly, and an independent panel of judges evaluated their performance.
RESULTS:
A total of 30 international groups were engaged. The entries reveal a general convergence of practices on most elements of the analysis and interpretation process. However, even given this commonality of approach, only two groups identified the consensus candidate variants in all disease cases, demonstrating a need for consistent fine-tuning of the generally accepted methods. There was greater diversity of the final clinical report content and in the patient consenting process, demonstrating that these areas require additional exploration and standardization.
CONCLUSIONS:
The CLARITY Challenge provides a comprehensive assessment of current practices for using genome sequencing to diagnose and report genetic diseases. There is remarkable convergence in bioinformatic techniques, but medical interpretation and reporting are areas that require further development by many groups
- âŠ