6,326 research outputs found
Theory of extraordinary transmission of light through quasiperiodic arrays of subwavelength holes
By using a theoretical formalism able to work in both real and k-spaces, the
physical origin of the phenomenon of extraordinary transmission of light
through quasi-periodic arrays of holes is revealed. Long-range order present in
a quasiperiodic array selects the wavevector(s) of the surface electromagnetic
mode(s) that allows an efficient transmission of light through subwavelength
holes.Comment: 4 pages, 4 figure
Wavelets: a powerful tool for studying rotation, activity, and pulsation in Kepler and CoRoT stellar light curves
Aims. The wavelet transform has been used as a powerful tool for treating
several problems in astrophysics. In this work, we show that the time-frequency
analysis of stellar light curves using the wavelet transform is a practical
tool for identifying rotation, magnetic activity, and pulsation signatures. We
present the wavelet spectral composition and multiscale variations of the time
series for four classes of stars: targets dominated by magnetic activity, stars
with transiting planets, those with binary transits, and pulsating stars.
Methods. We applied the Morlet wavelet (6th order), which offers high time and
frequency resolution. By applying the wavelet transform to the signal, we
obtain the wavelet local and global power spectra. The first is interpreted as
energy distribution of the signal in time-frequency space, and the second is
obtained by time integration of the local map. Results. Since the wavelet
transform is a useful mathematical tool for nonstationary signals, this
technique applied to Kepler and CoRoT light curves allows us to clearly
identify particular signatures for different phenomena. In particular, patterns
were identified for the temporal evolution of the rotation period and other
periodicity due to active regions affecting these light curves. In addition, a
beat-pattern signature in the local wavelet map of pulsating stars over the
entire time span was also detected.Comment: Accepted for publication on A&
Hilbert number for a family of piecewise nonautonomous equations
For family , we
solve three basic problems related with its dynamics. First, we characterize
when it has a center (Poincar\'e center focus problem). Second, we show that
each equation has a finite number of limit cycles (finiteness problem), and
finally we give a uniform upper bound for the number of limit cycles (Hilbert's
16th problem).Comment: 16 pages, no figure
Type Ia supernovae and the ^{12}C+^{12}C reaction rate
The experimental determination of the cross-section of the ^{12}C+^{12}C
reaction has never been made at astrophysically relevant energies (E<2 MeV).
The profusion of resonances throughout the measured energy range has led to
speculation that there is an unknown resonance at E\sim1.5 MeV possibly as
strong as the one measured for the resonance at 2.14 MeV. We study the
implications that such a resonance would have for the physics of SNIa, paying
special attention to the phases that go from the crossing of the ignition curve
to the dynamical event. We use one-dimensional hydrostatic and hydrodynamic
codes to follow the evolution of accreting white dwarfs until they grow close
to the Chandrasekhar mass and explode as SNIa. In our simulations, we account
for a low-energy resonance by exploring the parameter space allowed by
experimental data. A change in the ^{12}C+^{12}C rate similar to the one
explored here would have profound consequences for the physical conditions in
the SNIa explosion, namely the central density, neutronization, thermal
profile, mass of the convective core, location of the runaway hot spot, or time
elapsed since crossing the ignition curve. For instance, with the largest
resonance strength we use, the time elapsed since crossing the ignition curve
to the supernova event is shorter by a factor ten than for models using the
standard rate of ^{12}C+^{12}C, and the runaway temperature is reduced from
\sim8.14\times10^{8} K to \sim4.26\times10^{8} K. On the other hand, a
resonance at 1.5 MeV, with a strength ten thousand times smaller than the one
measured at 2.14 MeV, but with an {\alpha}/p yield ratio substantially
different from 1 would have a sizeable impact on the degree of neutronization
of matter during carbon simmering. We conclude that a robust understanding of
the links between SNIa properties and their progenitors will not be attained
until the ^{12}C+^{12}C reaction rate is measured at energies \sim1.5 MeV.Comment: 15 pages, 6 tables, 10 figures, accepted for Astronomy and
Astrophysic
Gamma-rays from Type Ia supernova SN2014J
The whole set of INTEGRAL observations of type Ia supernova SN2014J, covering
the period 19-162 days after the explosion has being analyzed. For spectral
fitting the data are split into "early" and "late" periods covering days 19-35
and 50-162, respectively, optimized for Ni and Co lines. As
expected for the early period much of the gamma-ray signal is confined to
energies below 200 keV, while for the late period it is most strong above
400 keV. In particular, in the late period Co lines at 847 and 1248 keV
are detected at 4.7 and 4.3 respectively. The lightcurves in several
representative energy bands are calculated for the entire period. The resulting
spectra and lightcurves are compared with a subset of models. We confirm our
previous finding that the gamma-ray data are broadly consistent with the
expectations for canonical 1D models, such as delayed detonation or
deflagration models for a near-Chandrasekhar mass WD. Late optical spectra (day
136 after the explosion) show rather symmetric Co and Fe lines profiles,
suggesting that unless the viewing angle is special, the distribution of
radioactive elements is symmetric in the ejecta.Comment: 21 pages, 16 figures, accepted by Ap
Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis
Aim: The detection and prognosis of nephropathy in transthyretin amyloidosis depends on albuminuria and renal function. Knowing that urinary levels of alpha-1 microglobulin and beta-2 microglobulin reflect tubular dysfunction while urinary alpha-2 macroglobulin implies glomerular damage, we decide investigate the diagnostic value of these markers in the patients with transthyretin amyloidosis.
Methods: Serum and urinary samples collected from 30 patients and 11 asymptomatic carriers were tested for alpha-1 microglobulin, beta-2 microglobulin, alpha-2 macroglobulin, albumin, creatinine and cystatin C.
Results: Pathological urinary alpha-1 microglobulin was detected in 17 patients, beta-2 microglobulin in 6 and alpha-2 macroglobulin in 5; 5 patients had albuminuria (mg/g creatinine) 30-300 and in 20 patients values >300 were present. Asymptomatic carriers did not present pathological excretion of these biomarkers and albuminuria was >30 in 1 individual. The excretion rates of alpha-1 microglobulin and beta-2 microglobulin were positively correlated with albuminuria (P<0.001), serum creatinine (P<0.05) and cystatin C (P<0.001). Urinary alpha-2 macroglobulin was almost exclusively found in the presence of albuminuria, although their levels do not correlate.
Conclusion: Urinary biomarkers emerge as a potential approach to detect renal disease but unexpectedly, urinary alpha-2 macroglobulin was not a marker of the severity of albuminuria
Properties of Deflagration Fronts and Models for Type Ia Supernovae
Detailed models of the explosion of a white dwarf, which include
self-consistent calculations of the light curve and spectra, provide a link
between observational quantities and the underlying explosion.These
calculations assume spherical geometry and are based on parameterized
descriptions of the burning front during the deflagration phase. Recently,
first multi-dimensional calculations for nuclear burning fronts have been
performed. Although a fully consistent treatment of the burning fronts is
beyond the current state of the art, these calculations provided a new and
better understanding of the physics, and new descriptions for the flame
propagation have been proposed. Here, we have studied the influence on the
results of previous analyses of Type Ia Supernovae, namely, the nucleosynthesis
and structure of the expanding envelope. Our calculations are based on a set of
delayed detonation models with parameters that give a good account of the
optical and infrared light curves, and of the spectral evolution. In this
scenario, the burning front propagates first in a deflagration mode and,
subsequently, turns into a detonation. The explosions and light curves are
calculated using a one-dimensional Lagrangian radiation-hydro code, including a
detailed nuclear network.Comment: 9 pages, 4 figures, macros 'crckapb.sty'. The Astrophysical Journal
(accepted
The soluble transferrin receptor as a marker of iron homeostasis in normal subjects and in HFE-related hemochromatosis
Background and Objectives. The soluble transferrin receptor (sTfR) is a clinical marker of erythropoietic activity, also used in the diagnosis of iron deficiency. In the present paper we explore the meaning of this parameter in normal physiological conditions of iron homeostasis and in the setting
of iron overload due to hereditary hemochromatosis (HH).
Design and Methods. Reference values for sTfR were established in a population of 42 apparently healthy subjects, analyzed in relation to other hematologic parameters, namely, hemoglobin (Hb), mean corpuscular volume (MCV), transferrin saturation (TfSat) and serum ferritin. The same analysis was done in a group of 45 patients with HH who were homozygous for the C282Y mutation of HFE and had a wide range of TfSat values. In addition, individual serial profiles were analyzed in three patients.
Results. In normal subjects circulating sTfR correlated significantly with the TfSat level, reflecting the systemic effect of iron availability on the erythropoietic activity in a normal physiological steady state. A TfSat of 25% appeared as a threshold value, below which there was a progressive increase in sTfR; this increase in sTfR occurred concomitantly with a decrease in Hb, MCV and serum ferritin. In HH patients the up-regulation of sTfR started at TfSat values as high as 50%.
Interpretation and Conclusions. The fact that sTfR up-regulation started at higher TfSat values in HH patients suggests that the recognition of systemic iron available for erythropoiesis is altered in this condition. Based on these results, a new hypothesis is advanced, proposing that the HFE protein in involved as a sensor of systemic iron availability, via the soluble transferrin receptor
Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation. We have determined the structure of the complex between first CD2AP SH3 domain and ubiquitin and performed a structural and mutational analysis to decipher the determinants of the SH3-C binding mode to ubiquitin. We found that the Phe-to-Tyr mutation in CD2AP and in the homologous CIN85 SH3-C domain does not abrogate ubiquitin binding, in contrast to previous hypothesis and our findings for the first two CD2AP SH3 domains. The similar alternative binding mode of the SH3-C domains of these related adaptor proteins is characterised by a higher affinity to C-terminal extended ubiquitin molecules. We conclude that CD2AP/CIN85 SH3-C domain interaction with ubiquitin constitutes a new ubiquitin-binding mode involved in a different cellular function and thus changes the previously established mechanism of EGF-dependent CD2AP/CIN85 mono-ubiquitination. © 2013 Ortega Roldan et al
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