The Systems Analysis and Design Course: An Educators’ Assessment of the Importance and Coverage of Topics

This study examines instructors\u27 perceptions regarding the skills and topics that are most important in the teaching of a Systems Analysis and Design (“SAD”) course and the class time devoted to each. A large number of Information Systems (“IS”) educators at AACSB accredited schools across the United States were surveyed. Shannon‟s entropy is used to analyze the opinions and measure the agreement or disagreement among survey respondents. Findings suggest that object-oriented analysis and structured analysis are topics on which instructors spend the most time, and are also the topics for which there is the greatest disagreement regarding importance. Conversely, the greatest agreement among survey respondents occurs with topics that, on the whole, were perceived as less important and to which less class time is devoted. This analysis provides a basis for comparison to practitioner perceptions

Rare coding variants in ten genes confer substantial risk for schizophrenia

Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ultra-rare coding variants (URVs) in 10 genes as conferring substantial risk for schizophrenia (odds ratios of 3-50, PPeer reviewe

Utilization of mechanical power and associations with clinical outcomes in brain injured patients. a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

BackgroundThere is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes.MethodsIn this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale <= 12 before intubation) who required mechanical ventilation (MV) >= 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS).ResultsWe included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2-15.1], 13 J/min [IQR 10-17], and 14 J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22).ConclusionsExposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation

Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2-15.1], 13 J/min [IQR 10-17], and 14 J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22). Conclusions: Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction

The last 2000 years in Northern Yellowstone National Park Based on Multiproxy Data from Crevice Lake

Pollen, charcoal, diatoms, stable-isotope, and geochemical records were analyzed in high-resolution in cores obtained from Crevice Lake, a varved-sediment lake in northern Yellowstone National Park. The objective was to reconstruct the vegetation, fire, and ecohydrologic history of the watershed for the period from AD 0-1917 and compare the results with the PDSI reconstructions of Cook et al. (2004). Pollen percentages and accumulation rates provide information on vegetation and flowering season conditions. Charcoal accumulation rates (CHAR) provide information on fire activity, including fire size or intensity and fire frequency. Diatoms disclose the nature of spring nutrient status, time of ice off, and duration of lake stratification, with Cyclotella bodanica as an indicator of prolonged summer stratification. 18O values over the last 300 yr correlate well with reconstructed, discharge for the Yellowstone River (Graumlich et al., 2003), 18O and winter precipitation, suggesting a relationship between Organic carbon (Corg) is a qualitative indicator of organic productivity, and certain elements such as sulfur (S) and molybdenum (Mo) are indicators of anoxia and sulfate reduction. Prior to AD 1150, high values of C. bodanica suggest long periods of summer stratification, and more oxygen-deficient bottom waters are indicated by higher S and Mo concentrations and pyrite formation. High concentrations of Corg imply higher organic productivity or low degradation due to anoxia. Low charcoal and high pollen accumulation rates imply small and/or frequent, fires and long flowering periods. 18O values suggest dry conditions. From AD, Between AD 600-900, high 18O values and abundant C. michiganiana imply wet, 900 to 1100, low winters, and warm summers with prolonged stratification. Charcoal and pollen data indicate continued frequent or small fires and long flowering periods, and upper treeline was at a higher elevation at this time (K. Pierce, unpubl. data). The period from AD 1150-1700 features high variability in PDSI values, including extreme dry and wet 18O values match a PDSI wet interval at AD 1300, intervals. Low suggesting high winter precipitation. A shift from C. bodanica to Stephanodiscus medius and S. minutulus indicates longer or cooler springs than before, and low CHAR and PAR indicate low fire activity 18O values, and poor flowering. Between AD 1400 and 1525, low correspond with high CHAR peaks suggesting infrequent severe fire 18O, events during a wet interval. From AD 1500 to 1700, an increase in values and a slight rise in C. bodanica indicate warmer spring conditions, prolonged summer stratification, and perhaps shorter winters, with less precipitation, than before. From AD 1700 to 1800, 18O), lengthy summer, the proxy data indicate dry conditions (high stratification (high C. bodanica), large or severe fires (high CHAR), and increased forest cover (high PAR and arboreal pollen percentages). PDSI reveals modest drought event in mid 1800s, associated with winter 18O) near Crevice Lake. Greater seasonality during, precipitation (low this period may explain the diatom mixture of C. bodanica, S. medius, and S. minutulus. A large fire event was recorded at ca. 1850 and fires have been small or absent since then

A 2650-year-long record of environmental change from northern Yellowstone National Park based on a comparison of multiple proxy data

Geochemical, stable-isotope, pollen, charcoal, and diatom records were analyzed at high-resolution in cores obtained from Crevice Lake, a varved-sediment lake in northern Yellowstone National Park. The objective was to reconstruct the ecohydrologic, vegetation, and fire history of the watershed for the last 2650 years to better understand past climate variations at the forest-steppe transition. The data suggest a period of limited bottom-water anoxia, relatively wet winters, and cool springs and summers from 2650 to 2100 cal yrBP (700–150 BC). Dry warm conditions occurred between 2100 and 850–800 cal yrBP (150 BC and AD 1100–1150), when the lake was anoxic, winter precipitation was low, and summer stratification was protracted. The data are consistent with overall warmer/drier conditions during the Medieval Climate Anomaly, although they suggest a shift towards wetter winters within that period. The period from 850 to 800 cal yrBP (AD 1100–1150) to 250 cal yrBP (AD 1700) was characterized by greater water-column mixing and cooler spring/summer conditions than before. In addition, fire activity shifted towards infrequent large events and pollen production was low. From 250 to 150 cal yrBP (AD 1700–1800), winter precipitation was moderate compared to previous conditions, and the lake was again stratified, suggesting warm summers. Between 150 and 42 cal yrBP (AD 1800–1908), winter precipitation increased and spring and summer conditions became moderate. Metal pollution, probably from regional mining operations, is evident in the 1870s. Large fires occurred between ca. 1800–1880, but in general the forests were more closed than before. The Crevice Lake record suggests that the last 150 years of Yellowstone’s environmental history were characterized by intermediate conditions when compared with the previous 2500 years

The abduction from the Seraglio; Romance; Allegro vivace from the aria O, wie will ech triumphieren / Wolfgang Amadeus Mozart arrangement by Franz Lotz

https://orc.library.atu.edu/atu_vhs024/1000/thumbnail.jp

Holocene seasonal variability inferred from multiple proxy records from Crevice Lake, Yellowstone National Park, USA

A 9400-yr-old record from Crevice Lake, a semi-closed alkaline lake in northern Yellowstone National Park, was analyzed for pollen, charcoal, geochemistry, mineralogy, diatoms, and stable isotopes to develop a nuanced understanding of Holocene environmental history in a region of northern Rocky Mountains that receives both summer and winter precipitation. The limited surface area, conical bathymetry, and deep water (\u3e31 m) of Crevice Lake create oxygen-deficient conditions in the hypolimnion and preserve annually laminated sediment (varves) for much of the record. Pollen data indicate that the watershed supported a closed Pinus-dominated forest and low fire frequency prior to 8200 cal yr BP, followed by open parkland until 2600 cal yr BP, and open mixed-conifer forest thereafter. Fire activity shifted from infrequent stand replacing fires initially to frequent surface fires in the middle Holocene and stand-replacing events in recent centuries. Low values of δ18O suggest high winter precipitation in the early Holocene, followed by steadily drier conditions after 8500 cal yr BP. Carbonate-rich sediments before 5000 cal yr BP imply warmer summer conditions than after 5000 cal yr BP. High values of molybdenum (Mo), uranium (U), and sulfur (S) indicate anoxic bottom-waters before 8000 cal yr BP, between 4400 and 3900 cal yr BP, and after 2400 cal yr BP. The diatom record indicates extensive water-column mixing in spring and early summer through much of the Holocene, but a period between 2200 and 800 cal yr BP had strong summer stratification, phosphate limitation, and oxygen-deficient bottom waters. Together, the proxy data suggest wet winters, protracted springs, and warm effectively wet summers in the early Holocene and less snowpack, cool springs, warm dry summers in the middle Holocene. In the late Holocene, the region and lake experienced extreme changes in winter, spring, and summer conditions, with particularly short springs and dry summers and winters during the Roman Warm Period (~2000 cal yr BP) and Medieval Climate Anomaly (1200–800 cal yr BP). Long springs and mild summers occurred during the Little Ice Age, and these conditions persist to the present. Although the proxy data indicate effectively wet summer conditions in the early Holocene and drier conditions in the middle and late Holocene, none point specifically to changes in summer precipitation as the cause. Instead, summer conditions were governed by multi-seasonal controls on effective moisture that operated over multiple time scales