Creating a data analysis plan for the communication and teamwork skills assessment tool to measure the impact of high fidelity interprofessional education

Background: The impact of high fidelity interprofessional education (HF-IPE) on fostering teamwork and communication among undergraduate nursing, medicine, and pharmacy students has not been well established. The Communication and Teamwork Skills (CATS) assessment tool is one research instrument that could be used to measure the impact of HF-IPE on teamwork in undergraduate health sciences students. Purpose: The purpose of this research practicum project was to demonstrate advanced nursing competencies by participating in the data analysis phase of the research process and developing a data analysis plan for the CATS. Methods: Four methods were used to accomplish the purpose of the practicum including: conducting a comprehensive literature review; consulting with a statistician and a nurse researcher; developing the data analysis plan with SPSS codebooks, and testing the plan using a fictitious data set. Results: The data analysis plan developed for this practicum project was implemented successfully to analyze, summarize, interpret and display fictitious quantitative data from the CATS. The Paired t-test was selected as an appropriate statistical measure to determine differences between groups’ mean scores. Methods to organize, analyze and visually display the data are recommended including a high and low closed chart, bar graphs, and tables. Conclusion: This practicum project demonstrated the achievement of advanced nursing competencies by developing a data analysis plan that could be used to guide the analysis of the quantitative data collected using the CATS assessment tool

Parameterized reduced-order models using hyper-dual numbers.

The goal of most computational simulations is to accurately predict the behavior of a real, physical system. Accurate predictions often require very computationally expensive analyses and so reduced order models (ROMs) are commonly used. ROMs aim to reduce the computational cost of the simulations while still providing accurate results by including all of the salient physics of the real system in the ROM. However, real, physical systems often deviate from the idealized models used in simulations due to variations in manufacturing or other factors. One approach to this issue is to create a parameterized model in order to characterize the effect of perturbations from the nominal model on the behavior of the system. This report presents a methodology for developing parameterized ROMs, which is based on Craig-Bampton component mode synthesis and the use of hyper-dual numbers to calculate the derivatives necessary for the parameterization

Use of Cognitive Strategies in Rats: the Role of Estradiol and its Interaction with Dopamine

Accumulating evidence suggests a role for estrogen in the use of a particular cognitive strategy when solving a maze task. In order to confirm the role of estrogen in this phenomenon, ovariectomized (OVX) female rats receiving either high (~ 90 pg/ml) or low (~ 32 pg/ml) circulating levels of 17β-estradiol benzoate (E2) performed a plus maze task for a reward. Consistent with previous research, OVX rats receiving low levels of E2 utilized a striatum-mediated response strategy while OVX rats administered high levels of E2 employed a hippocampus-mediated place strategy. Furthermore, following a systemic injection of a moderate dose of either a dopamine D1 (SKF 83566, 0.1 mg/kg IP) or D2 (raclopride, 0.5 mg/kg IP) receptor antagonist, low E2 rats were seen to use the opposite strategy and exercise a hippocampus-mediated place strategy in order to obtain the reward. At the same doses, high E2 rats did not change from using a place strategy. At a lower dose, these drugs shifted high E2 rats such that they showed an equal propensity for either strategy; this was not observed in low E2 rats. These results corroborate previous findings that E2 plays a significant role in the use of either a response or place strategy when solving a maze for a reward. In addition, the shift in strategy after dopamine receptor blockade implies the importance of central dopamine function in selecting a cognitive strategy to solve such tasks. It is suggested that estrogen alters cognitive strategy not only by improving hippocampal function, but also by altering dopamine-regulated striatal function

Proceedings of the Third International Workshop on Jointed Structures.

The Third International Workshop on Jointed Structures was held from August 16th to 17th, 2012, in Chicago Illinois, following the ASME 2012 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Thirty two researchers from both the United States and international locations convened to discuss the recent progress of mechanical joints related research and associated efforts in addition to developing a roadmap for the challenges to be addressed over the next five to ten years. These proceedings from the workshop include the minutes of the discussions and follow up from the 2009 workshop [1], presentations, and outcomes of the workshop. Specifically, twelve challenges were formulated from the discussions at the workshop, which focus on developing a better understanding of uncertainty and variability in jointed structures, incorporating high fidelity models of joints in simulations that are tractable/efficient, motivating a new generation of researchers and funding agents as to the importance of joint mechanics research, and developing new insights into the physical phenomena that give rise to energy dissipation in jointed structures. The ultimate goal of these research efforts is to develop a predictive model of joint mechanics

A Consistency Analysis of Phase-Locked-Loop Testing and Control-Based Continuation for a Geometrically Nonlinear Frictional System

Two of the most popular vibration testing methods for nonlinear structures are control-based continuation and phase-locked-loop testing. In this paper, they are directly compared on the same benchmark system, for the first time, to demonstrate their general capabilities and to discuss practical implementation aspects. The considered system, which is specifically designed for this study, is a slightly arched beam clamped at both ends via bolted joints. It exhibits a pronounced softening-hardening behavior as well as an increasing damping characteristic due to the frictional clamping. Both methods are implemented to identify periodic responses at steady-state constituting the phase-resonant backbone curve and nonlinear frequency response curves. To ensure coherent results, the repetition variability is thoroughly assessed via an uncertainty analysis. It is concluded that the methods are in excellent agreement, taking into account the inherent repetition variability of the system

Fiscal Year 2008

This report summarizes design and modeling activities for the MEMS passive shock sensor. It provides a description of past design revisions, including the purposes and major differences between design revisions but with a focus on Revisions 4 through 7 and the work performed in fiscal year 2008 (FY08). This report is a reference for comparing different designs; it summarizes design parameters and analysis results, and identifies test structures. It also highlights some of the changes and or additions to models previously documented [Mitchell et al. 2006, Mitchell et al. 2008] such as the way uncertainty thresholds are analyzed and reported. It also includes dynamic simulation results used to investigate how positioning of hard stops may reduce vibration sensitivity

Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224

Mirtrons are a recently described category of microRNA (miRNA) relying on splicing rather than processing by the microprocessor complex to generate pre-miRNA precursors of the RNA interference (RNAi) pathway. Their discovery and subsequent verification provides important information about a distinct class of miRNA and inherent advantages that could be exploited to silence genes of interest. These include micro-processor-independent biogenesis, pol-II-dependent transcription, accurate species generation and the delivery of multiple artificial mirtrons as introns within a single host transcript. Here we determined the sequence motifs required for correct processing of the mmu-miR-1224 mirtron and incorporated these into artificial mirtrons targeting Parkinson's disease-associated LRRK2 and α-synuclein genes. By incorporating these rules associated with processing and splicing, artificial mirtrons could be designed and made to silence complementary targets either at the mRNA or protein level. We further demonstrate with a LRRK2 targeting artificial mirtron that neuronal-specific silencing can be directed under the control of the human synapsin promoter. Finally, multiple mirtrons were co-delivered within a single host transcript, an eGFP reporter, to allow simultaneous targeting of two or more targets in a combinatorial approach. Thus, the unique characteristics of artificial mirtrons make this an attractive approach for future RNAi applications

'I Wanna See Some History': Recent Writing on British Punk

© 2016 Cambridge University Press. Tucked away on the b-side of the Sex Pistols' third single, 'Pretty Vacant' (1977), is a cover version of The Stooges' 'No Fun'. The song had long been a staple of the Pistols' live set; on record, however, Johnny Rotten chose to open the track with a diatribe against those attempting to imbue the punk culture he helped instigate with broader socio-economic, cultural or political implications. 'Here we go now', he snarled, 'a sociology lecture, with a bit of psychology, a bit of neurology, a bit of fuckology'