Holocene climate variability from ice core records in the Ross Sea area (East Antarctica)

Past polar climate variability can be documented at high resolution thanks to ice core records, which have revealed significant Holocene variations in Antarctica. Paleotemperature reconstructions from Antarctic ice cores are mainly based on δ18O (δD) records, a proxy for local, precipitation-weighted atmospheric temperatures. Here, we present a new climate record spanning the past 12,000 years resulting from high resolution (10 cm) stable isotope analyses of the ice core drilled at Talos Dome (TD) in East Antarctica from 2003 to 2007 in the framework of the TALDICE (TALos Dome Ice CorE) project. Talos Dome (72° 49’S, 15911’E; 2315 m; -41°C) is an ice dome on the edge of the East Antarctic plateau, where moisture is mainly advected from the Indian and western Pacific sectors of the Southern Ocean. Pacific moisture arriving at TD has been transported above the Ross Sea, where extensive presence of sea ice also occurs during summer. High-resolution δ18O data have been measured using both IRMS and CRDS techniques on 10 cm samples, leading to a mean time resolution of two years. The long-term trend of the TALDICE δ18O profile shows characteristic features already observed in other ice cores from the East Antarctic plateau. Following the approach of Pol et al. (2011), high frequency climate variability has been investigated using a 3000-year running standard deviation on the de-trended record. The results are compared to the same analysis performed on the nearby Taylor Dome ice core δ18O O data, which is the single East Antarctic ice core showing a strong Holocene decreasing trend. Despite these trend differences, both sites share common features regarding changes in variance. We also investigate changes in deuterium excess, a proxy reflecting changes in moisture source conditions. Both deuterium excess records show a two-step increasing trend in the first part of the Holocene. Taylor Dome deuterium excess however depicts an enhanced variability since about 7000 years BP. A wavelet analysis shows a change in isotopic variability patterns at 6-7000 years BP at both sites, suggesting changes in regional climate variability attributed to the opening of the Ross Sea area after the deglaciation

Two-microphone spatial filtering provides speech reception benefits for cochlear implant users in difficult acoustic environments

This article introduces and provides an assessment of a spatial-filtering algorithm based on two closely-spaced (∼1 cm) microphones in a behind-the-ear shell. The evaluated spatial-filtering algorithm used fast (∼10 ms) temporal-spectral analysis to determine the location of incoming sounds and to enhance sounds arriving from straight ahead of the listener. Speech reception thresholds (SRTs) were measured for eight cochlear implant (CI) users using consonant and vowel materials under three processing conditions: An omni-directional response, a dipole-directional response, and the spatial-filtering algorithm. The background noise condition used three simultaneous time-reversed speech signals as interferers located at 90°, 180°, and 270°. Results indicated that the spatial-filtering algorithm can provide speech reception benefits of 5.8 to 10.7 dB SRT compared to an omni-directional response in a reverberant room with multiple noise sources. Given the observed SRT benefits, coupled with an efficient design, the proposed algorithm is promising as a CI noise-reduction solution.National Institutes of Health (U.S.) (Grant R01 DC 000117)National Institutes of Health (U.S.) (Grant R01 DC DC7152)National Institutes of Health (U.S.) (Grant 2R44DC010524-02

Padronização de métodos para análise granulométrica no Brasil.

bitstream/item/96926/1/ComTec-66-Analise-Granulometrica.pd

Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure

Dimeric/oligomeric states of G-protein coupled receptors have been difficult to target. We report here bivalent ligands consisting of two identical oxytocin-mimetics that induce a three order magnitude boost in G-protein signaling of oxytocin receptors (OTRs) in vitro and a 100- and 40-fold gain in potency in vivo in the social behavior of mice and zebrafish. Through receptor mutagenesis and interference experiments with synthetic peptides mimicking transmembrane helices (TMH), we show that such superpotent behavior follows from the binding of the bivalent ligands to dimeric receptors based on a TMH1-TMH2 interface. Moreover, in this arrangement, only the analogues with a well-defined spacer length (∼25 Å) precisely fit inside a channel-like passage between the two protomers of the dimer. The newly discovered oxytocin bivalent ligands represent a powerful tool for targeting dimeric OTR in neurodevelopmental and psychiatric disorders and, in general, provide a framework to untangle specific arrangements of G-protein coupled receptor dimers

Late Holocene sedimentation in coastal areas of the northwestern Ross Sea (Antarctica).

Sediment cores and box cores collected in two coastal areas of the northwestern Ross Sea (Antarctica) highlight the possibility of studying the Late Holocene period in detail. In this work we propose a study on two box cores and two gravity cores collected in the Cape Hallett and Wood Bay areas during the 2005 PNRA oceanographic cruise. The two sites are feed by Eastern Antarctic Ice Shelf (EAIS) and previous studies have highlighted a complex postglacial sedimentary sequence, also influenced by local morphology. This study is performed within the framework of the PNRA-ESF PolarCLIMATE HOLOCLIP (Holocene climate variability at high-southern latitudes: an integrated perspective) Project. The data set includes: magnetic susceptibility, X-ray analyses, 210Pb, 14C dating, diatoms and foraminifera assemblages, organic carbon, and grain-size analyses. Furthermore XRF core scanner analyses, colour analysis from digital images, and major, minor and trace element concentration analyses (ICP-AES) are performed. Data show that the box core and upper core sediments represent a very recent sedimentation in which it is possible to observe the parameter variability probably linked to climate variability/changes: these variation will be compared with isotopic record form ice cores collected form the same Antarctic sector

Communications Biophysics

COntains reports on six research projects.National Institutes of Health (Grant 2 P01 MH-04737-06)National Institutes of Health (Grant 5 ROl NB-05462-02)Joint Services Electronics Programs (U. S. Army, U. S. Navy, and U. S. Air Force) under Contract DA 36-039-AMC-03200(E)National Science Foundation (Grant GK-835)National Aeronautics and Space Administration (Grant NsG-496

LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior

Behavioral changes in response to stressful stimuli can be controlled via adaptive epigenetic changes in neuronal gene expression. Here we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing isoform neuroLSD1, in the modulation of emotional behavior. In mouse hippocampus, we show that LSD1 and neuroLSD1 can interact with transcription factor serum response factor (SRF) and set the chromatin state of SRF-targeted genes early growth response 1 (egr1) and c-fos. Deletion or reduction of neuroLSD1 in mutant mice translates into decreased levels of activating histone marks at egr1 and c-fos promoters, dampening their psychosocial stress-induced transcription and resulting in low anxiety-like behavior. Administration of suberoylanilide hydroxamine to neuroLSD1(KO) mice reactivates egr1 and c-fos transcription and restores the behavioral phenotype. These findings indicate that LSD1 is a molecular transducer of stressful stimuli as well as a stress-response modifier. Indeed, LSD1 expression itself is increased acutely at both the transcriptional and splicing levels by psychosocial stress, suggesting that LSD1 is involved in the adaptive response to stress

Antarctic temperature changes during the last millennium: evaluation of simulations and reconstructions

Temperature changes in Antarctica over the last millennium are investigated using proxy records, a set of simulations driven by natural and anthropogenic forcings and one simulation with data assimilation. Over Antarctica, a long term cooling trend in annual mean is simulated during the period 1000–1850. The main contributor to this cooling trend is the volcanic forcing, astronomical forcing playing a dominant role at seasonal timescale. Since 1850, all the models produce an Antarctic warming in response to the increase in greenhouse gas concentrations. We present a composite of Antarctic temperature, calculated by averaging seven temperature records derived from isotope measurements in ice cores. This simple approach is supported by the coherency displayed between model results at these data grid points and Antarctic mean temperature. The composite shows a weak multi-centennial cooling trend during the pre-industrial period and a warming after 1850 that is broadly consistent with model results. In both data and simulations, large regional variations are superimposed on this common signal, at decadal to centennial timescales. The model results appear spatially more consistent than ice core records. We conclude that more records are needed to resolve the complex spatial distribution of Antarctic temperature variations during the last millennium