Effect of Snake Populations on Salamanders as a Result of Forest Fragmentation

Forest fragmentation is one of the main causes for the loss of native biodiversity. One consequence is increased proportion of edge habitat that introduces new “edge” species, and makes habitat for interior forest-living species less-suitable. This study was conducted at three sites in Tucker County, West Virginia and included one downhill ski slope, one cross country ski slope, and one gravel road. The main objectives of this study were to determine relative abundance of snake communities, how far species move from edge habitat into the forest and to determine whether snakes are a predatory threat to salamanders, specifically the federally protected Cheat Mountain Salamander (Plethodon nettingi). Area constrained surveys were conducted at each site from June through mid-October 2009. Three transects were placed at each study site and a vegetation analysis was conducted to quantify changes in plant communities. Snakes found were measured for snout-to-vent length and total length. Gender was determined and each specimen marked for recapture data. Results show the majority of snakes were found along the forest edge under cover objects where direct sunlight heats the ground and rocks. The highest concentration of all salamander species were found along transects deeper into the forest. Snake species observed included 44 Northern Ring-necked Snakes (Diadophis punctatus edwardsii), 15 Red-bellied Snakes (Storeria o. occipitomaculata), 35 Eastern Gartersnakes (Thamnophis s. sirtalis) and 5 Smooth Greensnakes (Opheodrys vernalis), all of which include a diet of salamanders to some extent. Results from this study will not only provide data on the implications of forest fragmentation, but will also provide the US Fish and Wildlife Service vital information on revising the Cheat Mountain Salamanders recovery plan

Differentially private inference via noisy optimization

We propose a general optimization-based framework for computing differentially private M-estimators and a new method for constructing differentially private confidence regions. Firstly, we show that robust statistics can be used in conjunction with noisy gradient descent or noisy Newton methods in order to obtain optimal private estimators with global linear or quadratic convergence, respectively. We establish local and global convergence guarantees, under both local strong convexity and self-concordance, showing that our private estimators converge with high probability to a nearly optimal neighborhood of the non-private M-estimators. Secondly, we tackle the problem of parametric inference by constructing differentially private estimators of the asymptotic variance of our private M-estimators. This naturally leads to approximate pivotal statistics for constructing confidence regions and conducting hypothesis testing. We demonstrate the effectiveness of a bias correction that leads to enhanced small-sample empirical performance in simulations. We illustrate the benefits of our methods in several numerical examples

Toward the Development of a Quick, Reliable Assessment Tool for Reflective Journals

Reflective practice, including reflective writing, can facilitate enriched learning, especially when implemented as part of a service-learning (SL) experience. Reflection is a central component of service-learning (SL) experiences. Students’ reflective abilities are often measured through reflective journaling; however, assessment of students’ reflective journals is not always efficient and straightforward. The goal of the present study was to establish a simple, reliable, and relatively quick tool for use by busy college instructors seeking to encourage students’ deep learning through reflective writing. A total of 258 reflective journals from 43 graduate students in speech-language pathology were evaluated by three raters using a three-tier assessment framework (nonreflection, reflection, and critical reflection) after Mezirow (1990) and Plack et al. (2005). Although previous studies found moderate to high interrater agreement and reliability, the current study did not support this finding. Strengths and weaknesses of the assessment framework and qualitative observations of the assessment process are discussed

Toward the Development of a Quick, Reliable Assessment Tool for Reflective Journals

Reflective practice, including reflective writing, can facilitate enriched learning, especially when implemented as part of a service-learning (SL) experience. Reflection is a central component of service-learning (SL) experiences. Students’ reflective abilities are often measured through reflective journaling; however, assessment of students’ reflective journals is not always efficient and straightforward. The goal of the present study was to establish a simple, reliable, and relatively quick tool for use by busy college instructors seeking to encourage students’ deep learning through reflective writing. A total of 258 reflective journals from 43 graduate students in speech-language pathology were evaluated by three raters using a three-tier assessment framework (nonreflection, reflection, and critical reflection) after Mezirow (1990) and Plack et al. (2005). Although previous studies found moderate to high interrater agreement and reliability, the current study did not support this finding. Strengths and weaknesses of the assessment framework and qualitative observations of the assessment process are discussed

Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD.

BACKGROUND: Germline pathogenic variants in SDHB/SDHC/SDHD are the most frequent causes of inherited phaeochromocytomas/paragangliomas. Insufficient information regarding penetrance and phenotypic variability hinders optimum management of mutation carriers. We estimate penetrance for symptomatic tumours and elucidate genotype-phenotype correlations in a large cohort of SDHB/SDHC/SDHD mutation carriers. METHODS: A retrospective survey of 1832 individuals referred for genetic testing due to a personal or family history of phaeochromocytoma/paraganglioma. 876 patients (401 previously reported) had a germline mutation in SDHB/SDHC/SDHD (n=673/43/160). Tumour risks were correlated with in silico structural prediction analyses. RESULTS: Tumour risks analysis provided novel penetrance estimates and genotype-phenotype correlations. In addition to tumour type susceptibility differences for individual genes, we confirmed that the SDHD:p.Pro81Leu mutation has a distinct phenotype and identified increased age-related tumour risks with highly destabilising SDHB missense mutations. By Kaplan-Meier analysis, the penetrance (cumulative risk of clinically apparent tumours) in SDHB and (paternally inherited) SDHD mutation-positive non-probands (n=371/67 with detailed clinical information) by age 60 years was 21.8% (95% CI 15.2% to 27.9%) and 43.2% (95% CI 25.4% to 56.7%), respectively. Risk of malignant disease at age 60 years in non-proband SDHB mutation carriers was 4.2%(95% CI 1.1% to 7.2%). With retrospective cohort analysis to adjust for ascertainment, cumulative tumour risks for SDHB mutation carriers at ages 60 years and 80 years were 23.9% (95% CI 20.9% to 27.4%) and 30.6% (95% CI 26.8% to 34.7%). CONCLUSIONS: Overall risks of clinically apparent tumours for SDHB mutation carriers are substantially lower than initially estimated and will improve counselling of affected families. Specific genotype-tumour risk associations provides a basis for novel investigative strategies into succinate dehydrogenase-related mechanisms of tumourigenesis and the development of personalised management for SDHB/SDHC/SDHD mutation carriers

A critical review of the use of 3-D printing in the construction industry

3-D printing, which is an automated production process with layer-by-layer control, has been gaining rapid development in recent years. The technology has been adopted in the manufacturing industry for decades and has recently been introduced in the construction industry to print houses and villas. The technology can bring significant benefits to the construction industry in terms of increased customization, reduced construction time, reduced manpower, and construction cost. A few isolated products and projects have been preliminarily tested using the 3-D printing technology. However, it should be noted that such tests and developments on the use of 3-D printing in the construction industry are very fragmented at the time of the study. It is therefore necessary for the building and construction industry to understand the technology, its historical applications and challenges for better utilization in the future. A systematic review shows that 3-D printing technology, after years of evolution, can be used to print large-scale architectural models and buildings. However, the potential of the technology is limited by the lack of large-scale implementation, the development of building information modeling, the requirements of mass customization, and the life cycle cost of the printed projects. It is therefore expected that future studies should be conducted on these areas to consolidate the stability and expand the applicability of 3-D printing in the construction industry

Examining the reliability and validity of the Clinical Assessment Interview for Negative Symptoms within the Management of Schizophrenia in Clinical Practice (MOSAIC) multisite national study

The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition. Temporal stability of negative symptoms was assessed across a 3-month follow-up. Results replicated the two-factor structure of the CAINS reflecting Motivation and Pleasure and expression symptoms. The CAINS scales exhibited high internal consistency and temporal stability. Convergent validity was supported by significant correlations between the CAINS subscales with other negative symptom measures. Additionally, the CAINS was significantly correlated with functioning and quality of life. Discriminant validity was demonstrated by small to moderate associations between the CAINS and positive symptoms, depression, and cognition (and these associations were comparable to those found with other negative symptom scales). Findings suggest that the CAINS is a reliable and valid tool for measuring negative symptoms in schizophrenia across diverse clinical samples and settings