75 research outputs found
The consequences of nuclear electron capture in core collapse supernovae
The most important weak nuclear interaction to the dynamics of stellar core
collapse is electron capture, primarily on nuclei with masses larger than 60.
In prior simulations of core collapse, electron capture on these nuclei has
been treated in a highly parameterized fashion, if not ignored. With realistic
treatment of electron capture on heavy nuclei come significant changes in the
hydrodynamics of core collapse and bounce. We discuss these as well as the
ramifications for the post-bounce evolution in core collapse supernovae.Comment: Accepted by PRL, 5 pages, 2 figure
The Role of Electron Captures in Chandrasekhar Mass Models for Type Ia Supernovae
The Chandrasekhar mass model for Type Ia Supernovae (SNe Ia) has received
increasing support from recent comparisons of observations with light curve
predictions and modeling of synthetic spectra. It explains SN Ia events via
thermonuclear explosions of accreting white dwarfs in binary stellar systems,
being caused by central carbon ignition when the white dwarf approaches the
Chandrasekhar mass. As the electron gas in white dwarfs is degenerate,
characterized by high Fermi energies for the high density regions in the
center, electron capture on intermediate mass and Fe-group nuclei plays an
important role in explosive burning. Electron capture affects the central
electron fraction Y_e, which determines the composition of the ejecta from such
explosions. Up to the present, astrophysical tabulations based on shell model
matrix elements were only available for light nuclei in the sd-shell. Recently
new Shell Model Monte Carlo (SMMC) and large-scale shell model diagonalization
calculations have also been performed for pf-shell nuclei. These lead in
general to a reduction of electron capture rates in comparison with previous,
more phenomenological, approaches. Making use of these new shell model based
rates, we present the first results for the composition of Fe-group nuclei
produced in the central regions of SNe Ia and possible changes in the
constraints on model parameters like ignition densities and burning front
speeds.Comment: 26 pages, 8 figures, submitted to Ap
Supernova Remnants as Clues to Their Progenitors
Supernovae shape the interstellar medium, chemically enrich their host
galaxies, and generate powerful interstellar shocks that drive future
generations of star formation. The shock produced by a supernova event acts as
a type of time machine, probing the mass loss history of the progenitor system
back to ages of 10 000 years before the explosion, whereas supernova
remnants probe a much earlier stage of stellar evolution, interacting with
material expelled during the progenitor's much earlier evolution. In this
chapter we will review how observations of supernova remnants allow us to infer
fundamental properties of the progenitor system. We will provide detailed
examples of how bulk characteristics of a remnant, such as its chemical
composition and dynamics, allow us to infer properties of the progenitor
evolution. In the latter half of this chapter, we will show how this exercise
may be extended from individual objects to SNR as classes of objects, and how
there are clear bifurcations in the dynamics and spectral characteristics of
core collapse and thermonuclear supernova remnants. We will finish the chapter
by touching on recent advances in the modeling of massive stars, and the
implications for observable properties of supernovae and their remnants.Comment: A chapter in "Handbook of Supernovae" edited by Athem W. Alsabti and
Paul Murdin (18 pages, 6 figures
Gravitational Waves from Gravitational Collapse
Gravitational wave emission from the gravitational collapse of massive stars
has been studied for more than three decades. Current state of the art
numerical investigations of collapse include those that use progenitors with
realistic angular momentum profiles, properly treat microphysics issues,
account for general relativity, and examine non--axisymmetric effects in three
dimensions. Such simulations predict that gravitational waves from various
phenomena associated with gravitational collapse could be detectable with
advanced ground--based and future space--based interferometric observatories.Comment: 68 pages including 13 figures; revised version accepted for
publication in Living Reviews in Relativity (http://www.livingreviews.org
Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy
<p>Abstract</p> <p>Background</p> <p>Miltefosine, which is the first oral drug licensed for the treatment of leishmaniasis, was recently reported to be a promising lead compound for the synthesis of novel antischistosomal derivatives with potent activity <it>in vivo </it>against different developmental stages of <it>Schistosoma mansoni</it>. In this paper an <it>in vitro </it>study was carried out to investigate whether it has a biocidal activity against the aquatic stages of <it>Schistosoma mansoni </it>and its snail intermediate host, <it>Biomphalaria alexandrina </it>, thus being also a molluscicide. Additionally, to see whether miltefosine can have a broad spectrum antischistosomal activity, a similar <it>in vitro </it>study was carried out on the adult stage of <it>Schistosoma haematobium</it>, the second major human species, its larval stages and snail intermediate host, <it>Bulinus truncutes</it>. This was checked by scanning electron microscopy.</p> <p>Results</p> <p>Miltefosine proved to have <it>in vitro </it>ovicidal, schistolarvicidal and lethal activity on adult worms of both <it>Schistosoma </it>species and has considerable molluscicidal activity on their snail hosts. Scanning electron microscopy revealed several morphological changes on the different stages of the parasite and on the soft body of the snail, which further strengthens the current evidence of miltefosine's activity. This is the first report of mollusicidal activity of miltefosine and its <it>in vitro </it>schistosomicidal activity against <it>S.haematobium</it>.</p> <p>Conclusions</p> <p>This study highlights miltefosine not only as a potential promising lead compound for the synthesis of novel broad spectrum schistosomicidal derivatives, but also for molluscicidals.</p
Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy
Two transitional type~Ia supernovae located in the Fornax cluster member NGC 1404: SN 2007on and SN 2011iv
We present an analysis of ultraviolet (UV) to near-infrared observations of the fast-declining Type Ia supernovae (SNe Ia) 2007on and 2011iv, hosted by the Fornax cluster member NGC 1404. The B-band light curves of SN 2007on and SN 2011iv are characterised by dm_15(B) decline-rate values of 1.96 mag and 1.77 mag, respectively. Although they have similar decline rates, their peak B- and H-band magnitudes differ by ~0.60 mag and ~0.35 mag, respectively. After correcting for the luminosity vs. decline rate and the luminosity vs. colour relations, the peak B-band and H-band light curves provide distances that differ by ~14% and ~9%, respectively. These findings serve as a cautionary tale for the use of transitional SNe Ia located in early-type hosts in the quest to measure cosmological parameters. Interestingly, even though SN 2011iv is brighter and bluer at early times, by three weeks past maximum and extending over several months, its B-V colour is 0.12 mag redder than that of SN 2007on. To reconcile this unusual behaviour, we turn to guidance from a suite of spherical one-dimensional Chandrasekhar-mass delayed-detonation explosion models. In this context, 56Ni production depends on both the so-called transition density and the central density of the progenitor white dwarf. To first order, the transition density drives the luminosity-width relation, while the central density is an important second-order parameter. Within this context, the differences in the B-V color evolution along the Lira regime suggests the progenitor of SN~2011iv had a higher central density than SN~2007on
Analogs of alkyllysophospholipids: chemistry, effects on the molecular level and their consequences for normal and malignant cells
In the search for new approaches to cancer therapy, the first alkyllysophospholipid (ALP) analogs were designed and studied about two decades ago, either as potential immunomodulators or as antimetabolites of phospholipid metabolism. In the meantime, it has been demonstrated that they really act in this way. However, their special importance is based on the fact that, in addition, they interfere with key events of signal transduction, such as hormone (or cytokine)-receptor binding or processing, protein kinase C or phospholipase C function and phosphatidylinositol and calcium metabolism. There are no strict structural requirements for their activity. Differences in the cellular uptake or the state of cellular differentiation seem to be mainly responsible for higher or lower sensitivities of cells towards ALP analogs. Consequences of the molecular effects mentioned on the cellular level are cytostasis, induction of differentiation (while in contrast the effects of known inducers of differentiation such as 12-O-tetradecanoylphorbol-13-acetate are inhibited, probably as a consequence of protein kinase C inhibition) and loss of invasive properties. Already in sublytic concentrations, alterations in the membrane structure were observed, and lysis may begin at concentrations not much higher than those causing the other effects described. Few ALP analogs have already entered clinical studies or are in clinical use. ALP analogs are the only antineoplastic agents that do not act directly on the formation and function of the cellular replication machinery. Therefore, their effects are independent of the proliferative state of the target cells. Because of their interference with cellular regulatory events, including those failing in cancer cells, ALP analogs, beyond their clinical importance, are interesting model compounds for the development of new, more selective drugs for cancer therapy
- âŠ