112 research outputs found

    Modified Organized Systems by Incorporation of Carbon Allotropes and Derivatives for Electron Shuttle, ET, FRET, MEF, and Quantum Biology Coupling

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    Fil: GarcĂ­a Quismondo, E. IMDEA Energy. Electrochemical Processes Unit, EspaĂąa.Fil: Bracamonte, A. Guillermo. Universidad Nacional de CĂłrdoba.Facultad de Ciencias QuĂ­micas. Departamento de QuĂ­mica OrgĂĄnica, Argentina.Fil: Bracamonte, A. Guillermo. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de Investigaciones en FĂ­sicoquĂ­mica de CĂłrdoba, Argentina.This communication was brief to show how high conjugated carbon-based structures and carbon allotropes could participate as electron shuttles, semiconductors, quantum emitters, and Optoelectronic processors within confined nanostructured organized systems. In particular, it was focused on nanoassemblies such as vesicles, micelles, and lipidic nanoparticles and incorporated insights from other types of nanomaterials that could afford to develop new organized systems. In these cases, the term organized system was used for all types of molecular assembly and supramolecular systems that formed structures within the nanoscale. In this manner, the incorporation of 0pto-electronic materials permitted the development of critical photo-physical phenomena with high impact and perspectives within technology and life sciences. Thus, it was led to discuss the participation of carbon-based chemical structures incorporated in different confined molecular media to develop i) Electron Transfer (ET) processes, ii) Reaction Electron Transfers (RET), iii) catalysis, iv) quantum emissions, v) Fluorescence Resonance Energy Transfer (FRET); vi) non-classical Light; and vii) Nano-Optics. Therefore, it was intended to present the most important physical and chemical phenomena where they could participate as functional high electronic conjugated chemical structures highlighting carbon allotropes.info:eu-repo/semantics/publishedVersionFil: GarcĂ­a Quismondo, E. IMDEA Energy. Electrochemical Processes Unit, EspaĂąa.Fil: Bracamonte, A. Guillermo. Universidad Nacional de CĂłrdoba.Facultad de Ciencias QuĂ­micas. Departamento de QuĂ­mica OrgĂĄnica, Argentina.Fil: Bracamonte, A. Guillermo. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de Investigaciones en FĂ­sicoquĂ­mica de CĂłrdoba, Argentina

    Gene expression response to a nematode parasite in novel and native eel hosts

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    Invasive parasites are involved in population declines of new host species worldwide. The high susceptibilities observed in many novel hosts have been attributed to the lack of protective immunity to the parasites which native hosts acquired during their shared evolution. We experimentally infected Japanese eels (Anguilla japonica) and European eels (Anguilla anguilla) with Anguillicola crassus, a nematode parasite that is native to the Japanese eel and invasive in the European eel. We inferred gene expression changes in head kidney tissue from both species, using RNA‐seq data to determine the responses at two time points during the early stages of infection (3 and 23 days postinfection). At both time points, the novel host modified the expression of a larger and functionally more diverse set of genes than the native host. Strikingly, the native host regulated immune gene expression only at the earlier time point and to a small extent while the novel host regulated these genes at both time points. A low number of differentially expressed immune genes, especially in the native host, suggest that a systemic immune response was of minor importance during the early stages of infection. Transcript abundance of genes involved in cell respiration was reduced in the novel host which may affect its ability to cope with harsh conditions and energetically demanding activities. The observed gene expression changes in response to a novel parasite that we observed in a fish follow a general pattern observed in amphibians and mammals, and suggest that the disruption of physiological processes, rather than the absence of an immediate immune response, is responsible for the higher susceptibility of the novel host

    Cambios morfolĂłgicos en la poblaciĂłn somatotropa inducidos por terapia gĂŠnica neonatal con el vector RAd-FTS en ratones nude

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    Se ha detectado un eje bidireccional timo-pituitario, hallĂĄndose receptores de GH en las cĂŠlulas epiteliales tĂ­micas. La GH estimularĂ­a la secreciĂłn de timulina, mientras que los niveles bajos de timulina circulante en perĂ­odo prenatal inducirĂ­an hipopituitarismo. El presente estudio tiene por objetivo: implementar una terapia gĂŠnica mediante el vector adenoviral RAd-FTS en ratones inmunodeficientes, con el fin de prevenir cambios en la poblaciĂłn somatotropa

    Patients presenting with miliaria while wearing flame resistant clothing in high ambient temperatures: a case series

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    <p>Abstract</p> <p>Introduction</p> <p>Clothing can be a cause of occupational dermatitis. Frequent causes of clothing-related dermatological problems can be the fabric itself and/or chemical additives used in the laundering process, friction from certain fabrics excessively rubbing the skin, or heat retention from perspiration-soaked clothing in hot working environments. To the best of our knowledge, these are the first reported cases of miliaria rubra associated with prolonged use of flame resistant clothing in the medical literature.</p> <p>Case presentation</p> <p>We report 18 cases (14 men and 4 women, with an age range of 19 to 37 years) of moderate to severe skin irritation associated with wearing flame resistant clothing in hot arid environments (temperature range: 39 to 50°C, 5% to 25% relative humidity). We describe the medical history in detail of a 23-year-old Caucasian woman and a 31-year-old African-American man. A summary of the other 16 patients is also provided.</p> <p>Conclusions</p> <p>These cases illustrate the potential serious nature of miliaria with superimposed <it>Staphylococcus </it>infections. All 18 patients fully recovered with topical skin treatment and modifications to their dress ensemble. Clothing, in particular blend fabrics, must be thoroughly laundered to adequately remove detergent residue. While in hot environments, individuals with sensitive skin should take the necessary precautions such as regular changing of clothing and good personal hygiene to ensure that their skin remains as dry and clean as possible. It is also important that they report to their health care provider as soon as skin irritation or rash appears to initiate any necessary medical procedures. Miliaria rubra can take a week or longer to clear, so removal of exposure to certain fabric types may be necessary.</p

    Control de Cydia molesta (Busck.) (Lepidoptera: Olethreutidae) por el mĂŠtodo de confusiĂłn sexual en CĂłrdoba (Argentina)

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    Durante los aĂąos 1995/96 y 1997/98 se llevaron a cabo en CĂłrdoba (Argentina)experiencias para evaluar el control de Cydia molesta mediante el mĂŠtodo de confusiĂłn sexual. El ensayo se realizĂł sobre un lote plantado con duraznero variedad Novedad de CĂłrdoba de maduraciĂłn semitardĂ­a. Se colocaron 300 emisores de feromona sintĂŠtica por hectĂĄrea. Se observĂł una reducciĂłn drĂĄstica de captura de machos adultos en ambos aĂąos en el ĂĄrea de confusiĂłn (1,8% y 0,7% respectivamente, de insectos capturados con respecto al testigo). El daĂąo en frutos tambiĂŠn se redujo significativamente, ya que en el ĂĄrea de confusiĂłn se obtuvieron 0,9% de frutos atacados contra 11,7% en el testigo, lo que significa un 92,3% de control en el primer aĂąo. En el segundo aĂąo el ataque a frutos se elevĂł a 1,2% con 88% de control. El ataque en brotes se redujo a valores de 3,1 % dentro del ĂĄrea de confusiĂłn y de 8,9% en el testigo, es decir 64,6% de control en 1995, y 2,6% con 71,2% de control en 1997. Estos resultados indican que el mĂŠtodo de confusiĂłn sexual es eficiente en el control de C. molesta en CĂłrdoba, en variedades de maduraciĂłn semitardĂ­a

    Identification of compound heterozygous variants in LRP4 D\demonstrates that a pathogenic variant outside the third beta-propeller domain can cause sclerosteosis

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    Sclerosteosis is a high bone mass disorder, caused by pathogenic variants in the genes encoding sclerostin or LRP4. Both proteins form a complex that strongly inhibits canonical WNT signaling activity, a pathway of major importance in bone formation. So far, all reported disease-causing variants are located in the third beta-propeller domain of LRP4, which is essential for the interaction with sclerostin. Here, we report the identification of two compound heterozygous variants, a known p.Arg1170Gln and a novel p.Arg632His variant, in a patient with a sclerosteosis phenotype. Interestingly, the novel variant is located in the first beta-propeller domain, which is known to be indispensable for the interaction with agrin. However, using luciferase reporter assays, we demonstrated that both the p.Arg1170Gln and the p.Arg632His variant in LRP4 reduced the inhibitory capacity of sclerostin on canonical WNT signaling activity. In conclusion, this study is the first to demonstrate that a pathogenic variant in the first beta-propeller domain of LRP4 can contribute to the development of sclerosteosis, which broadens the mutational spectrum of the disorder.Diabetes mellitus: pathophysiological changes and therap

    On the nature of defects in liquid-phase exfoliated graphene

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    Liquid-phase exfoliation is one of the most promising routes for large-scale production of multilayer graphene dispersions. These dispersions, which may be used in coatings, composites, or paints, are believed to contain disorder-free graphene multilayers. Here, we address the nature of defects in such samples obtained by liquid-phase exfoliation of graphite powder in N-methyl-2-pyrrolidone. Our Raman spectroscopy data challenge the assumption that these multilayers are free of bulk defects, revealing that defect localization strongly depends on the sonication time. For short ultrasound times, defects are located mainly at the layer edges but they turn out to build up in the bulk for ultrasonic times above 2 h. This knowledge may help to devise better strategies to achieve high-quality graphene dispersions.submittedVersionFil: Bracamonte, MarĂ­a Victoria. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de FĂ­sica Enrique Gaviola; Argentina.Fil: Bracamonte, MarĂ­a Victoria. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, AstronomĂ­a y FĂ­sica; Argentina.Fil: Lacconi, Gabriela InĂŠs. Universidad Nacional de CĂłrdoba. Facultad de Ciencias QuĂ­micas. Departamento de FisicoquĂ­mica; Argentina.Fil: Lacconi, Gabriela InĂŠs. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de Investigaciones en FisicoquĂ­mica de CĂłrdoba; Argentina.Fil: Urreta, Silvia Elena. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de FĂ­sica Enrique Gaviola; Argentina.Fil: Urreta, Silvia Elena. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, AstronomĂ­a y FĂ­sica; Argentina.Fil: Foa Torres, Luis Eduardo Francisco. Consejo Nacional de Investigaciones CientĂ­ficas y TĂŠcnicas. Instituto de FĂ­sica Enrique Gaviola; Argentina.Fil: Foa Torres, Luis Eduardo Francisco. Universidad Nacional de CĂłrdoba. Facultad de MatemĂĄtica, AstronomĂ­a y FĂ­sica; Argentina.FĂ­sica de los Materiales Condensado

    Therapy Insight: Parenteral Estrogen treatment for Prostate Cancer—a new dawn for an old therapy

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    Oral estrogens were the treatment of choice for carcinoma of the prostate for over four decades, but were abandoned because of an excess of cardiovascular and thromboembolic toxicity. It is now recognized that most of this toxicity is related to the first pass portal circulation, which upregulates the hepatic metabolism of hormones, lipids and coagulation proteins. Most of this toxicity can be avoided by parenteral (intramuscular or transdermal) estrogen administration, which avoids hepatic enzyme induction. It also seems that a short-term but modest increase in cardiovascular morbidity (but not mortality) is compensated for by a long-term cardioprotective benefit, which accrues progressively as vascular remodeling develops over time. Parenteral estrogen therapy has the advantage of giving protection against the effects of andropause (similar to the female menopause), which are induced by conventional androgen suppression and include osteoporotic fracture, hot flashes, asthenia and cognitive dysfunction. In addition, parenteral estrogen therapy is significantly cheaper than contemporary endocrine therapy, with substantive economic implications for health providers

    Track D Social Science, Human Rights and Political Science

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138414/1/jia218442.pd
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