212 research outputs found
Plausibility functions and exact frequentist inference
In the frequentist program, inferential methods with exact control on error
rates are a primary focus. The standard approach, however, is to rely on
asymptotic approximations, which may not be suitable. This paper presents a
general framework for the construction of exact frequentist procedures based on
plausibility functions. It is shown that the plausibility function-based tests
and confidence regions have the desired frequentist properties in finite
samples---no large-sample justification needed. An extension of the proposed
method is also given for problems involving nuisance parameters. Examples
demonstrate that the plausibility function-based method is both exact and
efficient in a wide variety of problems.Comment: 21 pages, 5 figures, 3 table
Multifragment production in Au+Au at 35 MeV/u
Multifragment disintegration has been measured with a high efficiency
detection system for the reaction at . From the event
shape analysis and the comparison with the predictions of a many-body
trajectories calculation the data, for central collisions, are compatible with
a fast emission from a unique fragment source.Comment: 9 pages, LaTex file, 4 postscript figures available upon request from
[email protected]. - to appear in Phys. Lett.
Statistical Multifragmentation in Central Au+Au Collisions at 35 MeV/u
Multifragment disintegrations, measured for central Au + Au collisions at E/A
= 35 MeV, are analyzed with the Statistical Multifragmentation Model. Charge
distributions, mean fragment energies, and two-fragment correlation functions
are well reproduced by the statistical breakup of a large, diluted and
thermalized system slightly above the multifragmentation threshold.Comment: Latex file, 8 pages + 4 postscript figures available upon request
from [email protected]
Statistical Multifragmentation of Non-Spherical Expanding Sources in Central Heavy-Ion Collisions
We study the anisotropy effects measured with INDRA at GSI in central
collisions of Xe+Sn at 50 A.MeV and Au+Au at 60, 80, 100 A.MeV incident energy.
The microcanonical multifragmentation model with non-spherical sources is used
to simulate an incomplete shape relaxation of the multifragmenting system. This
model is employed to interpret observed anisotropic distributions in the
fragment size and mean kinetic energy. The data can be well reproduced if an
expanding prolate source aligned along the beam direction is assumed. An either
non-Hubblean or non-isotropic radial expansion is required to describe the
fragment kinetic energies and their anisotropy. The qualitative similarity of
the results for the studied reactions suggests that the concept of a
longitudinally elongated freeze-out configuration is generally applicable for
central collisions of heavy systems. The deformation decreases slightly with
increasing beam energy.Comment: 35 pages, 19 figures, submitted to Nuclear Physics
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Molecular and Historical Aspects of Corn Belt Dent Diversity
Tens-of-thousands of open-pollinated cultivars of corn (Zea mays L.) are being maintained in germplasm banks. Knowledge of the amount and distribution of genetic variation within and among accessions can aid end users in choosing among them. We estimated molecular genetic variation and looked for influences of pedigree, adaptation, and migration in the genetic makeup of conserved Corn-Belt Dent-related germplasm. Plants sampled from 57 accessions representing Corn-Belt Dents, Northern Flints, Southern Dents, plus 12 public inbreds, were genotyped at 20 simple sequence repeat (SSR) loci. For 47 of the accessions, between 5 and 23 plants per accession were genotyped (mean = 9.3). Mean number of alleles per locus was 6.5 overall, 3.17 within accessions, and 3.20 within pooled inbreds. Mean gene diversity was 0.53 within accessions and 0.61 within pooled inbreds. Open-pollinated accessions showed a tendency toward inbreeding (FIS = 0.09), and 85% of genetic variation was shared among them. A Fitch-Margoliash tree strongly supported the distinctiveness of flint from dent germplasm but did not otherwise reveal evidence of genetic structure. Mantel tests revealed significant correlations between genetic distance and geographical (r = 0.54, P= 0.04) or maturity zone (r = 0.33, P = 0.03) distance only if flint germplasm was included in the analyses. A significant correlation (r = 0.76, P \u3c 0.01) was found between days to pollen shed and maturity zone of accession origin. Pedigree, rather than migration or selection, has most influenced the genetic structure of the extant representatives of the open-pollinated cultivars at these SSR loci
Source size scaling of fragment production in projectile breakup
Fragment production has been studied as a function of the source mass and
excitation energy in peripheral collisions of Cl+Au at 43
MeV/nucleon and Ge+Ti at 35 MeV/nucleon. The results are
compared to the Au+Au data at 600 MeV/nucleon obtained by the ALADIN
collaboration. A mass scaling, by 35 to 190, strongly
correlated to excitation energy per nucleon, is presented, suggesting a thermal
fragment production mechanism. Comparisons to a standard sequential decay model
and the lattice-gas model are made. Fragment emission from a hot, rotating
source is unable to reproduce the experimental source size scaling.Comment: 13 pages LaTeX file, including 3 postscript figures (in .tar.gz
fornmat), accepted in Phys. Rev. C . Also available at
http://thomson.phy.ulaval.ca/ions_lourds/gil-en.htm
The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: The COSMIC Collaboration
Background Changes in criteria and differences in populations studied and methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform criteria were applied to harmonized data from 11 studies from USA, Europe, Asia and Australia, and MCI prevalence estimates determined using three separate definitions of cognitive impairment. Results The published range of MCI prevalence estimates was 5.0%-36.7%. This was reduced with all cognitive impairment definitions: performance in the bottom 6.681% (3.2%-10.8%); Clinical Dementia Rating of 0.5 (1.8%-14.9%); Mini-Mental State Examination score of 24-27 (2.1%-20.7%). Prevalences using the first definition were 5.9% overall, and increased with age (P < .001) but were unaffected by sex or the main races/ethnicities investigated (Whites and Chinese). Not completing high school increased the likelihood of MCI (P = .01). Conclusion Applying uniform criteria to harmonized data greatly reduced the variation in MCI prevalence internationally
TRY plant trait database â enhanced coverage and open access
Plant traitsâthe morphological, anatomical, physiological, biochemical and phenological characteristics of plantsâdetermine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of traitâbased plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traitsâalmost complete coverage for âplant growth formâ. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and traitâenvironmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives
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