15 research outputs found
Salvage high-dose chemotherapy in female patients with relapsed/refractory germ-cell tumors: A retrospective analysis of the European Group for Blood and Marrow Transplantation (EBMT)
Background: High-dose chemotherapy (HDC) with hematopoietic progenitor cell transplantation is a standard option for relapsed/refractory testicular germ-cell tumor (GCT), but only few data have been reported in female patients with GCT. We conducted a retrospective analysis of female patients with GCT treated with HDC and registered with the European Society for Blood and Marrow Transplantation. Patients and methods: Between 1985 and 2013, 60 registered female patients with GCT, median age 27 years (range 15-48), were treated with salvage HDC. Forty patients (67%) had primary ovarian GCT, 8 (13%) mediastinal, 7 (12%) retroperitoneal and 5 (8%) other primary sites/unknown. Twenty-two patients (37%) received HDC as second-line therapy, 29 (48%) as third-line, and 9 (15%) as fourth- to sixth-line. Nine of 60 patients (15%) received HDC as late-intensification with no evidence of metastasis before HDC. The conditioning HDC regimens comprised carboplatin in 51 of 60 cases (85%), and consisted of a single HDC cycle in 31 cases (52%), a multi-cycle HDC regimen in 29 (48%). Results: Nine cases who underwent late intensification HDC were not evaluable for response. Of the other 51 assessable patients, 17 (33%) achieved a complete response (CR), 8 (16%) a marker-negative partial remission (PRm-), 5 (10%) a marker-positive partial remission, 5 (10%) stable disease, and 13 (25%) progressive disease. There were 3 toxic deaths (6%). With an overall median follow-up of 14 months (range 1-219), 7 of 9 (78%) patients with late intensification and 18 of the 25 patients (72%) achieving a CR/PRm- following HDC were free of relapse/progression. In total, 25 of 60 patients (42%) were progression-free following HDC at a median follow-up of 87 months (range 3-219 months). Conclusions: Salvage HDC based on carboplatin represents a therapeutic option for female patients with relapsed/refractory GCT
Analyser la restauration des petits marais littoraux : origine, montage et principaux apports du programme PEPPS
National audiencePour faire face aux impacts du changement climatique et relever le dĂ©fi du dĂ©clin de la biodiversitĂ©, la question de la dĂ©poldĂ©risation des petits marais littoraux est de plus en interrogĂ©e. Câest dans ce contexte quâa Ă©tĂ© menĂ© le programme de recherche « Pertinence environnementale de la restauration des petits marais et prĂ©s salĂ©s » (PEPPS, 2018-2021). Dans cet article, les auteurs prĂ©sentent les objectifs et lâapproche de ce programme. Ils font Ă©galement le point des principaux apports en termes de connaissances sur les dynamiques et les processus de la restauration des petits marais salĂ©s tant des points de vue Ă©cologiques que sociaux
Characteristics of the participants according to CAD status.
<p>Characteristics of the participants according to CAD status.</p
Association between <i>APOE</i> genotypes and other cardio-metabolic risk factors.
<p>Association between <i>APOE</i> genotypes and other cardio-metabolic risk factors.</p
Association between APOE genotype, cardiovascular risk factors, and CAD.
<p>Association between APOE genotype, cardiovascular risk factors, and CAD.</p
Association between lipid levels and <i>APOE</i> genotypes in non-CAD subjects.
<p>Association between lipid levels and <i>APOE</i> genotypes in non-CAD subjects.</p
Salvage high-dose chemotherapy in female patients with relapsed/refractory germ cell tumors: The EBMT experience.
Association of <i>APOE</i> gene polymorphism with lipid profile and coronary artery disease in Afro-Caribbeans
<div><p>Objectives</p><p>Apolipoprotein E gene (<i>APOE</i>) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups.</p><p>We evaluated, for the first time in an Afro-Caribbean population, the distribution of <i>APOE</i> polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors.</p><p>Methods</p><p>We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects. TaqMan assays were performed to genotype rs7412 and rs429358, the two variants that determine the <i>APOE</i> alleles Δ2, Δ3 and Δ4. The association between <i>APOE</i> genotype and the lipid profile was analysed by comparing Δ2 carriers, Δ3 homozygotes and Δ4 carriers.</p><p>Results</p><p>The frequencies of Δ2, Δ3 and Δ4 in the overall sample were 8%, 70% and 22%, respectively. CAD was not associated with <i>APOE</i> polymorphism. The total cholesterol level was higher in Δ4 carriers compared with Δ2 carriers: 5.07 vs 4.59 mmol/L (P = 0.016). The LDL-cholesterol level was lower in <i>APOE</i> Δ2 carriers compared with Δ3 homozygotes and Δ4 carriers: 2.65 vs 3.03 and 3.17 mmol/L, respectively (p = 0.002). The total cholesterol/HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios were similar in the three allelic groups. <i>APOE</i> polymorphism was not associated with diabetes, hypertension, waist circumference or body mass index.</p><p>Conclusions</p><p>Our results indicate that <i>APOE</i> gene polymorphism is associated with the lipid profile but not with CAD in Afro-Caribbean people. This lack of association with CAD may be explained by the low atherogenic profile observed in Δ4 carriers, which may warrant further investigation.</p></div