Validating the Philadelphia Mindfulness Scale [PMS] for Those with Fibromyalgia

Objectives: Dispositional mindfulness [DM] has become an important construct in understanding and treating fibromyalgia. However, few DM measures exist that have been validated in those with fibromyalgia. The Philadelphia Mindfulness Scale [PMS] is a self-report of DM. In the current study, we validate the PMS within a sample of individuals with fibromyalgia. Design: This was a cross-sectional online study. This enabled the recruitment of a larger sample of individuals with experiences of fibromyalgia than may have been achieved through face-to-face assessment. A cross-sectional approach was adopted to minimise resource demands. Method: The PMS alongside measures of fibromyalgia severity [The Revised Fibromyalgia Impact Questionnaire], affect [Positive and Negative Affect Scale] and decentring [Experiences Questionnaire] were completed online by a sample of N=936 individuals with fibromyalgia. Results: Confirmatory factor analysis supported a revised three-factor structure for the PMS. This factor structure excluded items which could overlap with hypervigilance within fibromyalgia. The three supported factors were Awareness, Non-judging/Control and Non-suppression/reactivity. Concurrent validity of the subscales was partially supported via correlations with positive affect [PA] and negative affect [NA] and decentring. Conclusions: The results support the use of the PMS in individuals with fibromyalgia, and in particular the use of this measure to compare those with and without experience of meditation. The PMS may be a useful tool in evaluating mindfulness-based interventions [MBIs] within this population. Limitations: The online design prevented more in-depth assessment of fibromyalgia. As the study was cross-sectional, test re-test reliability could not be assessed

Development of a practical heat of hydration model for concrete curing for geotechnical applications

Thermal integrity profiling (TIP) is a common non-destructive technique to evaluate the quality of construction of piles by analysing the temperature fields due to heat of hydration from freshly cast concrete piles. For this process to be accurate, a reliable concrete heat of hydration model is required. This paper proposes a practical and simple to calibrate four parameter model for the prediction of concrete heat of hydration. This model has been shown to be able to reproduce the evolution of heat of hydration measured in laboratory tests, as well as field measurements of temperature within curing concrete piles, as part of a thermal integrity profiling (TIP) operation performed at a site in London. With the simplicity of the model and the small number of model parameters involved, this model can be easily and quickly calibrated, enabling quick predictions of expected temperatures for subsequent casts using the same concrete mix

On the Thermal Activation of Turin Metro Line 2 Tunnels

The Turin metro Line 2 will extend for nearly 28 km and include 26 stations. It will connect the SW suburbs of the city to the NE ones. The excavation will be performed by means of TBM and Cut & Cover techniques and, once concluded, will host a fully automated driverless light metro. This paper will describe the feasibility study carried out to assess the energy potential of the thermal activation of the line by using an innovative tunnel lining segment (ENERTUN) recently patented and tested in real operating conditions. A novel methodology was adopted, involving thermo-hydraulic 3D FE numerical anal- yses to identify the geothermal potential for the different sections of the line. A study of the possible collectors for the thermal energy produced was also performed considering the planned stations, the existing buildings and the future urban developments

Liquefaction hazard of the Groningen region of the Netherlands due to induced seismicity

The operator of the Groningen gas field is leading an effort to quantify the seismic hazard and riskof the region due to induced earthquakes, includingoverseeing one of the most comprehensive liquefaction hazard studies performedgloballyto date. Due tothe unique characteristics of the seismic hazard and the geologic deposits in Groningen, efforts first focused on developing relationships for a Groningen-specific liquefaction triggering model. The liquefaction hazard was then assessedusing a Monte Carlo method, wherein a range of credibleevent scenarios were considered in computingliquefaction damage-potentialhazard curves. Thiseffort entailed the use of a regional stochastic seismic source model,ground motion prediction equation,site response model,and geologic model that were developed as part of the broader regional seismic hazardassessment.“No-to-Minor Surficial Liquefaction Manifestations”arepredicted for mostsites across the study areafor a 75-year return period. The only sites where “Moderate Surficial Liquefaction Manifestations” are predicted are in the town of Zandeweer, with only some of the sites in the townbeing predicted to experience this severityof liquefactionfor thisreturn period

Inflammatory Aetiology of Human Myometrial Activation Tested Using Directed Graphs

There are three main hypotheses for the activation of the human uterus at labour: functional progesterone withdrawal, inflammatory stimulation, and oxytocin receptor activation. To test these alternatives we have taken information and data from the literature to develop causal pathway models for the activation of human myometrium. The data provided quantitative RT-PCR results on key genes from samples taken before and during labour. Principal component analysis showed that pre-labour samples form a homogenous group compared to those during labour. We therefore modelled the alternative causal pathways in non-labouring samples using directed graphs and statistically compared the likelihood of the different models using structural equations and D-separation approaches. Using the computer program LISREL, inflammatory activation as a primary event was highly consistent with the data (p = 0.925), progesterone withdrawal, as a primary event, is plausible (p = 0.499), yet comparatively unlikely, oxytocin receptor mediated initiation is less compatible with the data (p = 0.091). DGraph, a software program that creates directed graphs, produced similar results (p = 0.684, p = 0.280, and p = 0.04, respectively). This outcome supports an inflammatory aetiology for human labour. Our results demonstrate the value of directed graphs in determining the likelihood of causal relationships in biology in situations where experiments are not possible

Number of People Blind or Visually Impaired by Glaucoma Worldwide and in World Regions 1990 – 2010: A Meta-Analysis

Objective: To assess the number of individuals visually impaired or blind due to glaucoma and to examine regional differences and temporal changes in this parameter for the period from 1990 to 2012. Methods: As part of the Global Burden of Diseases (GBD) Study 2010, we performed a systematic literature review for the period from 1980 to 2012. We primarily identified 14,908 relevant manuscripts, out of which 243 high-quality, population-based studies remained after review by an expert panel that involved application of selection criteria that dwelt on population representativeness and clarity of visual acuity methods used. Sixty-six specified the proportion attributable to glaucoma. The software tool DisMod-MR (Disease Modeling–Metaregression) of the GBD was used to calculate fraction of vision impairment due to glaucoma. Results: In 2010, 2.1 million (95% Uncertainty Interval (UI):1.9,2.6) people were blind, and 4.2 (95% UI:3.7,5.8) million were visually impaired due to glaucoma. Glaucoma caused worldwide 6.6% (95% UI:5.9,7.9) of all blindness in 2010 and 2.2% (95% UI:2.0,2.8) of all moderate and severe visual impairment (MSVI). These figures were lower in regions with younger populations (10%). From 1990 to 2010, the number of blind or visually impaired due to glaucoma increased by 0.8 million (95%UI:0.7, 1.1) or 62% and by 2.3 million (95%UI:2.1,3.5) or 83%, respectively. Percentage of global blindness caused by glaucoma increased between 1990 and 2010 from 4.4% (4.0,5.1) to 6.6%. Age-standardized prevalence of glaucoma related blindness and MSVI did not differ markedly between world regions nor between women. Significance: By 2010, one out of 15 blind people was blind due to glaucoma, and one of 45 visually impaired people was visually impaired, highlighting the increasing global burden of glaucoma

Energy performance of diaphragm walls used as heat exchangers

The possibility of equipping diaphragm walls as ground heat exchangers to meet the full or partial heating and cooling demands of overlying or adjacent buildings has been explored in recent years. In this paper, the factors affecting the energy performance of diaphragm walls equipped as heat exchangers are investigated through finite element modelling. The numerical approach employed is first validated using available experimental data and then applied to perform parametric analyses. Parameters considered in the analysis include panel width, the ratio between the wall and excavation depths, heat transfer pipe spacing, concrete cover, heat-carrier fluid velocity, concrete thermal properties and the temperature difference between the air within the excavation and the soil behind the wall. The results indicate that increasing the number of pipes by reducing their spacing is the primary route to increasing energy efficiency in the short term. However, the thermal properties of the wall concrete and the temperature excess within the excavation space are also important, with the latter becoming the most significant in the medium to long term. This confirms the benefits of exploiting the retaining walls installed for railway tunnels and metro stations where additional sources of heat are available

The Early Postnatal Nonhuman Primate Neocortex Contains Self-Renewing Multipotent Neural Progenitor Cells

The postnatal neocortex has traditionally been considered a non-neurogenic region, under non-pathological conditions. A few studies suggest, however, that a small subpopulation of neural cells born during postnatal life can differentiate into neurons that take up residence within the neocortex, implying that postnatal neurogenesis could occur in this region, albeit at a low level. Evidence to support this hypothesis remains controversial while the source of putative neural progenitors responsible for generating new neurons in the postnatal neocortex is unknown. Here we report the identification of self-renewing multipotent neural progenitor cells (NPCs) derived from the postnatal day 14 (PD14) marmoset monkey primary visual cortex (V1, striate cortex). While neuronal maturation within V1 is well advanced by PD14, we observed cells throughout this region that co-expressed Sox2 and Ki67, defining a population of resident proliferating progenitor cells. When cultured at low density in the presence of epidermal growth factor (EGF) and/or fibroblast growth factor 2 (FGF-2), dissociated V1 tissue gave rise to multipotent neurospheres that exhibited the ability to differentiate into neurons, oligodendrocytes and astrocytes. While the capacity to generate neurones and oligodendrocytes was not observed beyond the third passage, astrocyte-restricted neurospheres could be maintained for up to 6 passages. This study provides the first direct evidence for the existence of multipotent NPCs within the postnatal neocortex of the nonhuman primate. The potential contribution of neocortical NPCs to neural repair following injury raises exciting new possibilities for the field of regenerative medicine

The Gut Microbiota of Wild Mice

The gut microbiota profoundly affects the biology of its host. The composition of the microbiota is dynamic and is affected by both host genetic and many environmental effects. The gut microbiota of laboratory mice has been studied extensively, which has uncovered many of the effects that the microbiota can have. This work has also shown that the environments of different research institutions can affect the mouse microbiota. There has been relatively limited study of the microbiota of wild mice, but this has shown that it typically differs from that of laboratory mice (and that maintaining wild caught mice in the laboratory can quite quickly alter the microbiota). There is also inter-individual variation in the microbiota of wild mice, with this principally explained by geographical location. In this study we have characterised the gut (both the caecum and rectum) microbiota of wild caught Mus musculus domesticus at three UK sites and have investigated how the microbiota varies depending on host location and host characteristics. We find that the microbiota of these mice are generally consistent with those described from other wild mice. The rectal and caecal microbiotas of individual mice are generally more similar to each other, than they are to the microbiota of other individuals. We found significant differences in the diversity of the microbiotas among mice from different sample sites. There were significant correlations of microbiota diversity and body weight, a measure of age, body-mass index, serum concentration of leptin, and virus, nematode and mite infection