Occult Intraamniotic Infection at the Time of Midtrimester Genetic Amniocentesis: A Reassessment

Objective: The objective of this study was to reevaluate the incidence of occult early midtrimester intraamniotic infection in asymptomatic patients at the time of genetic amniocentesis

The Hepatitis C Virus E1 Glycoprotein Undergoes Productive Folding but Accelerated Degradation When Expressed as an Individual Subunit in CHO Cells

Hepatitis C Virus E1E2 heterodimers are components of the viral spike. Although there is a general agreement on the necessity of the co-expression of both E1 and E2 on a single coding unit for their productive folding and assembly, in a previous study using an in vitro system we obtained strong indications that E1 can achieve folding in absence of E2. Here, we have studied the folding pathway of unescorted E1 from stably expressing CHO cells, compared to the folding observed in presence of the E2 protein. A DTT-resistant conformation is achieved by E1 in both situations, consistent with the presence of an E2-independent oxidative pathway. However, while the E1E2 heterodimer is stable inside cells, E1 expressed alone is degraded within a few hours. On the other hand, the oxidation and stability of individually expressed E2 subunits is dependent on E1 co-expression. These data are consistent with E1 and E2 assisting each other for correct folding via different mechanisms: E2 assists E1 by stabilizing a semi-native conformation meanwhile E1 drives E2 towards a productive folding pathway

INTERFACES DA EDUCAÇÃO DE JOVENS E ADULTOS E EDUCAÇÃO ESPECIAL: O DIREITO EM ANÁLISE

O estudo tem como objetivo analisar como se configuram as interfaces da Educação de Jovens e Adultos (EJA) e da Educação Especial (EE) nas escolas da rede estadual de ensino do município de Colatina-ES no que se refere à efetivação do direito à educação. Tomamos como referências básicas para a discussão os preceitos constitucionais da educação como direito social, as formulações teóricas no campo das políticas educacionais para as modalidades da educação de jovens e adultos e educação especial partindo da concepção de educação como um direito humano fundamental e como aprendizagem ao longo da vida. Trata-se de uma pesquisa qualitativa, tendo como estratégia o estudo de caso realizado por meio de análise documental, observação participante, diário de campo, aplicação de questionários e de levantamento de dados no Instituto Brasileiro de Geografia e Estatística. Considerando os dados do total da população do município com deficiência, o número de matrículas de estudantes público-alvo da EE na EJA é ínfimo, observa-se que os educandos não estão matriculados nas escolas estaduais de educação básica, mas no Centro de Educação Estadual de Jovens e Adultos (CEEJA). De forma surpreendente, o processo da pesquisa revela que as interfaces da EJA e EE vêm sendo produzidas pelo protagonismo dos sujeitos e não pela política implementada, sendo assim, os sujeitos com suas diferentes vivências e saberes são os responsáveis por inverter a lógica da oferta da EJA no CEEJA. Ainda na análise da documentação da Secretaria Estadual de Educação do ES constatamos que existem lacunas na definição das políticas públicas educacionais para os sujeitos, o que nos leva à constatação de que o reconhecimento das modalidades da EJA e da EE como um direito ainda não se materializou como efetivação real no contexto político educacional brasileiro

The Dynamics of Aqueous Hydroxide Ion Transport Probed via Ultrafast Vibrational Echo Experiments

Paper presented at the Sixteenth International Conference on Ultrafast Phenomena.We use peakshift, transient grating, and 2D IR measurements to probe the dynamics of NaOD solutions. Our experiments suggest that OD- possesses a stable solvation shell and signatures of fast intermolecular proton transfer are observed

The structure of mixed H2O-OH monolayer films on Ru(0001)

Scanning tunneling microscopy (STM) and x-ray absorption spectroscopy (XAS) have been used to study the structures produced by water on Ru(0001) at temperatures above 140 K. It was found that while undissociated water layers are metastable below 140 K, heating above this temperature produces drastic transformations whereby a fraction of the water molecules partially dissociate and form mixed H{sub 2}O-OH structures. XPS and XAS revealed the presence of hydroxyl groups with their O-H bond essentially parallel to the surface. STM images show that the mixed H{sub 2}O-OH structures consist of long narrow stripes aligned with the three crystallographic directions perpendicular to the close-packed atomic rows of the Ru(0001) substrate. The internal structure of the stripes is a honeycomb network of H-bonded water and hydroxyl species. We found that the metastable low temperature molecular phase can also be converted to a mixed H{sub 2}O-OH phase through excitation by the tunneling electrons when their energy is 0.5 eV or higher above the Fermi level. Structural models based on the STM images were used for Density Functional Theory optimizations of the stripe geometry. The optimized geometry was then utilized to calculate STM images for comparison with the experiment

On-site magnetization in open antiferromagnetic chains: a classical analysis versus NMR experiments in a spin-1 compound

The response of an open spin chain with isotropic antiferromagnetic interactions to a uniform magnetic field is studied by classical Monte Carlo simulations. It is observed how the induced on-site magnetization is non uniform, due to the occurrence of edge staggered terms which decay exponentially over a distance equal to the zero field correlation length of the infinite chain. The total magnetic moment associated to each staggered term is found to be about half of the original single-spin magnitude and to decrease as the inverse of temperature (i.e. to behave as a Curie-like moment). The numerical results are compared to recent NMR findings in spinless-doped Y(2)BaNiO(5); the remarkable agreement found shows that, for temperatures above the Haldane gap, the classical approach gives a correct picture of the boundary effects observed in the Heisenberg S=1 chain.Comment: 4 pages, 4 eps figures; minor changes in the text; added reference

Topological Crystalline Insulator In A New Bi Semiconducting Phase

Topological crystalline insulators are a type of topological insulators whose topological surface states are protected by a crystal symmetry, thus the surface gap can be tuned by applying strain or an electric field. In this paper we predict by means of ab initio calculations a new phase of Bi which is a topological crystalline insulator characterized by a mirror Chern number nM =−2, but not a Z2 strong topological insulator. This system presents an exceptional property: at the (001) surface its Dirac cones are pinned at the surface high-symmetry points. As a consequence they are also protected by time-reversal symmetry and can survive against weak disorder even if in-plane mirror symmetry is broken at the surface. Taking advantage of this dual protection, we present a strategy to tune the band-gap based on a topological phase transition unique to this system. Since the spin-texture of these topological surface states reduces the back-scattering in carrier transport, this effective band-engineering is expected to be suitable for electronic and optoelectronic devices with reduced dissipatio