Contamination levels of human pharmaceutical compounds in French surface and drinking water.

International audienceThe occurrence of 20 human pharmaceutical compounds and metabolites from 10 representative therapeutic classes was analysed from resource and drinking water in two catchment basins located in north-west France. 98 samples were analysed from 63 stations (surface water and drinking water produced from surface water). Of the 20 human pharmaceutical compounds selected, 16 were quantified in both the surface water and drinking water, with 22% of the values above the limit of quantification for surface water and 14% for drinking water). Psychostimulants, non-steroidal anti-inflammatory drugs, iodinated contrast media and anxiolytic drugs were the main therapeutic classes of human pharmaceutical compounds detected in the surface water and drinking water. The results for surface water were close to results from previous studies in spite of differences in prescription rates of human pharmaceutical compounds in different countries. The removal rate of human pharmaceutical compounds at 11 water treatment units was also determined. Only caffeine proved to be resistant to drinking water treatment processes (with a minimum rate of 5%). Other human pharmaceutical compounds seemed to be removed more efficiently (average elimination rate of over 50%) by adsorption onto activated carbon and oxidation/disinfection with ozone or chlorine (not taking account of the disinfection by-products). These results add to the increasing evidence of the occurrence of human pharmaceutical compounds in drinking water that may represent a threat to human beings exposed to a cocktail of human pharmaceutical compounds and related metabolites and by-products in drinking water

The Structure of a Low-Metallicity Giant Molecular Cloud Complex

To understand the impact of low metallicities on giant molecular cloud (GMC) structure, we compare far infrared dust emission, CO emission, and dynamics in the star-forming complex N83 in the Wing of the Small Magellanic Cloud. Dust emission (measured by Spitzer as part of the S3MC and SAGE-SMC surveys) probes the total gas column independent of molecular line emission and traces shielding from photodissociating radiation. We calibrate a method to estimate the dust column using only the high-resolution Spitzer data and verify that dust traces the ISM in the HI-dominated region around N83. This allows us to resolve the relative structures of H2, dust, and CO within a giant molecular cloud complex, one of the first times such a measurement has been made in a low-metallicity galaxy. Our results support the hypothesis that CO is photodissociated while H2 self-shields in the outer parts of low-metallicity GMCs, so that dust/self shielding is the primary factor determining the distribution of CO emission. Four pieces of evidence support this view. First, the CO-to-H2 conversion factor averaged over the whole cloud is very high 4-11 \times 10^21 cm^-2/(K km/s), or 20-55 times the Galactic value. Second, the CO-to-H2 conversion factor varies across the complex, with its lowest (most nearly Galactic) values near the CO peaks. Third, bright CO emission is largely confined to regions of relatively high line-of-sight extinction, A_V >~ 2 mag, in agreement with PDR models and Galactic observations. Fourth, a simple model in which CO emerges from a smaller sphere nested inside a larger cloud can roughly relate the H2 masses measured from CO kinematics and dust.Comment: 17 pages, 10 figures (including appendix), accepted for publication in the Astrophysical Journa

The Influence of Concentration and Temperature on the Formation of γ-Oryzanol + β-Sitosterol Tubules in Edible Oil Organogels

The gelation process of mixtures of γ-oryzanol and sitosterol structurants in sunflower oil was studied using light scattering, rheology, and micro-scanning calorimetry (Micro-DSC). The relation between temperature and the critical aggregation concentration (CAC) of tubule formation of γ-oryzanol and sitosterol was determined using these techniques. The temperature dependence of the CAC was used to estimate the binding energy and enthalpic and entropic contribution to the tubular formation process. The binding energy calculated at the corresponding temperatures and CACs were relatively low, in order of 2 RT (4.5 kJ mol−1), which is in accord with the reversibility of the tubular formation process. The formation of the tubules was associated with negative (exothermic) enthalpy change (ΔH0) compared with positive entropy term (−T ΔS0 >0), indicating that the aggregation into tubules is an enthalpy-driven process. The oryzanol–sitosterol ratio affected the aggregation process; solutions with ratio of (60 oryzanol–40 sitosterol) started aggregation at higher temperature compared with other ratios

Tertiary and quaternary geology of the Belgian Continental Shelf

A synthesis of the geology of the Belgian continental shelf is here presented. The main part of this document is dedicated to the review of the lithostratigraphy, geotechnical properties, geometry and distribution of the Tertiary and Quaternary deposits. The data compilation, review and assessment have been conducted from the numerous existing studies and large data sets, available offshore, but also onland when offshore data were scarce or lacking. Three main projects have enabled to collect the offshore data: (1) the project “Seismic stratigraphy, Southern Bight, North Sea” (RCMG, City of London Polytechnic/NERC, University of Caen/CNRS); (2) the project “Seismisch onderzoek op het Belgisch Continentaal Plat. Eerste faze. Ontginningszone 2” (MEZ/Administratie van het Mijnwezen, RCMG); (3) the project “Studie oppervlaktelaag van het Belgisch Continentaal Plat. Seismisch prospectie sector B” MEZ/Belgian Geological Survey-BGD, RCMG). Data consist mainly of seismic profiles (16,000 km), cores (79) and cone penetration tests (CPTs, 177). All the data have been digitised and integrated in appropriate georeferenced softwares. Synthetic integrated maps and tables have been produced, aimed to provide the end-users with clear and directly usable information.This synthesis has been conducted in the framework of the project “Optimal Offshore Wind Energy Developments in Belgium”, financed by the Belgian federal government (Federal Office for Scientific, Technical and Cultural Affairs). This project is in keeping with the part I project network “Production patterns and sustainable consumption” of the PADD II program. Objectives of this project consisted in providing recommendations for the selection of sites that are convenient with respect to the stability of offshore wind structures and the minimisation of geo-environmental impacts

Hierarchical progressive surveys. Multi-resolution HEALPix data structures for astronomical images, catalogues, and 3-dimensional data cubes

Scientific exploitation of the ever increasing volumes of astronomical data requires efficient and practical methods for data access, visualisation, and analysis. Hierarchical sky tessellation techniques enable a multi-resolution approach to organising data on angular scales from the full sky down to the individual image pixels. Aims. We aim to show that the Hierarchical progressive survey (HiPS) scheme for describing astronomical images, source catalogues, and three-dimensional data cubes is a practical solution to managing large volumes of heterogeneous data and that it enables a new level of scientific interoperability across large collections of data of these different data types. Methods. HiPS uses the HEALPix tessellation of the sphere to define a hierarchical tile and pixel structure to describe and organise astronomical data. HiPS is designed to conserve the scientific properties of the data alongside both visualisation considerations and emphasis on the ease of implementation. We describe the development of HiPS to manage a large number of diverse image surveys, as well as the extension of hierarchical image systems to cube and catalogue data. We demonstrate the interoperability of HiPS and Multi-Order Coverage (MOC) maps and highlight the HiPS mechanism to provide links to the original data. Results. Hierarchical progressive surveys have been generated by various data centres and groups for ~200 data collections including many wide area sky surveys, and archives of pointed observations. These can be accessed and visualised in Aladin, Aladin Lite, and other applications. HiPS provides a basis for further innovations in the use of hierarchical data structures to facilitate the description and statistical analysis of large astronomical data sets.Comment: 21 pages, 6 figures. Accepted for publication in Astronomy & Astrophysic

Geo-environmental characterization of the Kwinte Bank

A detailed geomorphological and sedimentological study has been performed at a tidal sandbank, which has been dredged during 30 years. Localised intensive aggregate extraction created a depression in the central part of the sandbank, upon which the Government decided to close this section of the bank for further exploitation. Multibeam and side-scan sonar technology was used to survey the bank, in combination with extensive ground-truthing. Automated seabed classification was performed, but showed no direct correlation with the mean grain-size; the primary drivers influencing the classification being the sorting of the sediments, the presence of shells and of fine sediments. Very high resolution seismics revealed the internal architecture of the bank. In the central depression, the upper unit is locally severely dredged.The central depression is characterized by distinct morphosedimentary facies, compared to the western and eastern part of the bank and the Kwinte swale, adjacent of it. The difference between the western and the eastern part is essentially due to different tidal current characteristics, each having their particular sedimentation-erosion patterns. These processes seem to be rather stable, though the evolution of the sediments in the central depression shows similarities with the Kwinte swale sediment evolution.Since the depression is somewhat oblique to the normal crestline, it now forms an open transport pathway from the swale up to the crest of the sandbank. This led to a canalization of the flood current which is witnessed mostly by the northwards and faster progression of bedforms. Because of the difference in sediment characteristics between the dredged material and the present-day supply of sand, it is unlikely that natural processes will be able to counterbalance the severe dredging activities.Moreover, the presence of the central depression is located close to the kink of the sand bank, which is influenced by a high-energy hydrodynamic regime. Its presence could intensify the current action in this area and could enhance the evolution of the bank

Chemically engineered extracts of St John’s wort as sources of polyprenylated acylphloroglucinols to prevent endothelial dysfunction

International audienc

Mortality rates and division of labor in the leaf-cutting ant, Atta colombica

Division of labor in social groups is affected by the relative costs and benefits of conducting different tasks. However, most studies have examined the dynamics of division of labor, rather than the costs and benefits that presumably underlie the evolution of such systems. In social insects, division of labor may be simplistically described as a source-sink system, with external tasks, such as foraging, acting as sinks for the work force. The implications of two distinct sinks – foraging and waste-heap working – for division of labor were examined in the leaf-cutting ant Atta colombica. Intrinsic mortality rates were similar across external task groups. Exposure to waste (a task-related environment) led to a 60% increase in the mortality rate of waste-heap workers compared to workers not exposed to waste. Given the small number of workers present in the waste-heap task group, such increases in mortality are unlikely to affect division of labor and task allocation dramatically, except perhaps under conditions of stress