Problems and Promises of Qualitative Secondary Analysis for Research in Information Science (Paper)

Qualitative secondary analysis (QSA) is a method that has been applied in other disciplines even though it has rarely been explicitly used or discussed in information science. This paper discusses the epistemological and ethical issues surrounding QSA, explains the value of the method for information science research, discusses its benefits and challenges, and provides an example case study

Communication overload: a phenomenological inquiry into academic reference librarianship

Postprint of an article published in Journal of Documentation. Published article may be found at doi:10.1108/00220411211255996Purpose: This study provides insight on the meaning of communication overload as experienced by modern academic librarians. Communication is the essence of reference librarianship, and a practically endless array of synchronous and asynchronous communication tools (ICTs) are available to facilitate communication. Design/methodology/approach: This study relied on a phenomenological methodology, which included nine in-depth interviews with academic librarians. The interviews were transcribed and analyzed using RQDA, a qualitative analysis software package that facilitates coding, category building, and project management. Findings: Seven themes about librarianship emerged from this research: Attending to Communication Abundance, Librarians of Two Types, Instruction Not Reference, Twenty-first Century Librarianship, User Needs, Trusted Methods: Filter Not Retrieve, and Self-Impact. The shared meaning of communication overload, among these librarians, is that it is a problem when it detracts from or hinders their ability to assist their users. Practical implications: Further research should contribute to an understanding of communication as a problem when it interferes with serving the librarians' users, or to an understanding of interpersonal communication within the librarians' organizational structures and in their broader professional networks. Social implications: Research in popular psychology has focused on the negative impacts on productivity and concentration of living in an always-plugged-in environment. This research confirms that librarians should have time to work away from digital distractions to maintain job satisfaction. Originality/value: Important work by Radford and Dervin has focused on communication with users. This study focuses on the impact of ICTs on librarians' work and personal lives

Advancing Research for Library and Information Science with Qualitative Secondary Analysis

This paper presents the results of a study utilizing a seldom-used method in Library and Information Science (LIS): Qualitative Secondary Analysis. The data is drawn from two phenomenological studies about experiences of Reference and Information Services (RIS) librarians. We discuss how we repurposed the interview data in this study, and also the strengths, weaknesses, and wider applications of the method across LIS

Re-Conceiving Time in Reference and Information Services Work: A Qualitative Secondary Analysis

Purpose The purpose of this paper is to use the sociology of time to understand how time is perceived by academic librarians who provide reference and information service (RIS). Design/methodology/approach This study is a qualitative secondary analysis (QSA) of two phenomenological studies about the experience of RIS in academic libraries. The authors used QSA to re-analyze the interview transcripts to develop themes related to the perception of time. Findings Three themes about the experience of time in RIS work were identified. Participants experience time as discrete, bounded moments but sometimes experience threads through these moments that provide continuity, time is framed as a commodity that weighs on the value of the profession, and time plays an integral part of participants’ narratives and professional identities. Research limitations/implications Given that the initial consent processes vary across organizations and types of studies, the researchers felt ethically compelled to share only excerpts from each study’s data, rather than the entire data set, with others on the research team. Future qualitative studies should consider the potential for secondary analysis and build data management and sharing plans into the initial study design. Practical implications Most discussions of time in the literature are presented as a metric – time to answer a query, time to conduct a task – The authors offer a more holistic understanding of time and its relationship to professional work. Social implications The methodology taken in this paper makes sense of the experiences of work in RIS for librarians. It identifies commonalities between the experience of time and work for RIS professionals and those of other professionals, such as physicians and software engineers. It suggests revising models for RIS, as well as some professional values. Originality/value This paper contributes a better understanding of time, understudied as a phenomenon that is experienced or perceived, among RISs providers in academic libraries. The use of secondary qualitative analysis is an important methodological contribution to library and information science studies

Degradation of Bradykinin by Neutral Endopeptidase (EC 3.4.24.11) in Cultured Human Endothelial Cells

Peer Reviewe

Primary B-Cell Deficiencies Reveal a Link between Human IL-17-Producing CD4 T-Cell Homeostasis and B-Cell Differentiation

IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation and the circulating follicular T helper subset was recently shown to be enriched in Th17 cells able to help B-cell differentiation. We investigated a putative link between Th17-cell homeostasis and B cells by studying the Th17-cell compartment in primary B-cell immunodeficiencies. Common Variable Immunodeficiency Disorders (CVID), defined by defects in B-cell differentiation into plasma and memory B cells, are frequently associated with autoimmune and inflammatory manifestations but we found no relationship between these and Th17-cell frequency. In fact, CVID patients showed a decrease in Th17-cell frequency in parallel with the expansion of activated non-differentiated B cells (CD21lowCD38low). Moreover, Congenital Agammaglobulinemia patients, lacking B cells due to impaired early B-cell development, had a severe reduction of circulating Th17 cells. Finally, we found a direct correlation in healthy individuals between circulating Th17-cell frequency and both switched-memory B cells and serum BAFF levels, a crucial cytokine for B-cell survival. Overall, our data support a relationship between Th17-cell homeostasis and B-cell maturation, with implications for the understanding of the pathogenesis of inflammatory/autoimmune diseases and the physiology of B-cell depleting therapies

Follicular helper T cells are required for systemic autoimmunity

Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (TFH) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san allele of Roquin, which encodes a RING-type ubiquitin ligase, develop GCs in the absence of foreign antigen, excessive TFH cell numbers, and features of lupus. We postulated a positive selection defect in GCs to account for autoantibodies. We first demonstrate that autoimmunity in Roquinsan/san (sanroque) mice is GC dependent: deletion of one allele of Bcl6 specifically reduces the number of GC cells, ameliorating pathology. We show that Roquinsan acts autonomously to cause accumulation of TFH cells. Introduction of a null allele of the signaling lymphocyte activation molecule family adaptor Sap into the sanroque background resulted in a substantial and selective reduction in sanroque TFH cells, and abrogated formation of GCs, autoantibody formation, and renal pathology. In contrast, adoptive transfer of sanroque TFH cells led to spontaneous GC formation. These findings identify TFH dysfunction within GCs and aberrant positive selection as a pathway to systemic autoimmunity

Effect of ACE inhibitors on endothelial dysfunction: Unanswered questions and implications for further investigation and therapy

Experimental studies have suggested that angiotensin-converting enzyme (ACE) inhibitors may have an important role in blocking the progression of and/or reversing endothelial dysfunction. The extrapolation of these experimental studies to the clinical situation has, however, been disappointing. Studies of forearm-mediated endothelial vasodilatation in patients with hypertension with captopril, enalapril, and cilazapril have been negative. The finding of the Trial in Reversing Endothelial Dysfunction (TREND) that the administration of quinapril to normotensive patients with coronary artery disease in part restores endothelial-mediated coronary vasodilation, as assessed by intracoronary administration of acetylcholine, has important implications for future therapy and raises several important questions. The differences in the TREND and previous studies of ACE inhibitors on endothelial dysfunction may be due to mechanistic differences in endothelial dysfunction in patients with coronary artery disease and hypertension. Although in general there has been a good correlation between endothelial dysfunction as assessed by forearm flow and coronary endothelial dysfunction as assessed by acetylcholine, these vascular beds may be affected differently by therapeutic interventions, especially with an ACE inhibitor, which may affect sheart stress and angiotensin II formation in different vascular beds differently. Third, one needs to question whether the effect of quinapril on coronary endothelial dysfunction is a class effect or unique to quinapril. It will be necessary to test the effectiveness of other ACE inhibitors on coronary endothelial dysfunction in humans before concluding that the beneficial effects of quinapril are due to a class effect.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44542/1/10557_2004_Article_BF00051113.pd