Unconstrained Cross-Sectional Shape Optimisation of Cold-Formed Steel Beams and Beam-Columns

This paper is focused on optimising the cross-sectional shapes of simply-supported, singly-symmetric and open-section cold-formed steel (CFS) beams and beam-columns without manufacturing or assembly constraints. A previously developed Genetic Algorithm (GA) is used in this study. Fully restrained and unrestrained beams against lateral deflection and twist, as well as unrestrained beam-columns are optimised, of which the nominal member capacities are determined by the Direct Strength Method (DSM). The optimised cross-sectional shapes are presented and the evolution of the unrestrained cross-sectional shapes for various combinations of axial load and bending moment is analysed and discussed

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

The Compact Linear Collider (CLIC) - 2018 Summary Report

The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years

Unconstrained shape optimisation of singly-symmetric and open cold-formed steel beams and beam-columns

This study aims to optimise the cross-sectional shape of singly-symmetric, open-section and simply-supported cold-formed steel (CFS) beams and beam-columns. No manufacturing or assembly constraints are considered. The previously developed augmented Lagrangian Genetic Algorithm (GA), referred to as the self-shape optimisation algorithm, is used herein. Fully restrained and unrestrained beams against lateral deflection and twist, as well as unrestrained beam-columns are optimised. Various combinations of axial compressive load and bending moment are analysed for the beam-columns. The Direct Strength Method (DSM) is used to evaluate the nominal member compressive and bending capacities. The accuracy of the automated rules, developed in the literature to determine the elastic local and distortional axial buckling stresses from Finite Strip signature curves, is verified herein to estimate the elastic bending buckling stresses. The optimised cross-sectional shapes are presented for all cases and the evolution of the unrestrained shapes from pure axial compression to pure bending is discussed

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

An amendment to this paper has been published and can be accessed via a link at the top of the paper