The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater and archive data

Neodymium isotopic compositions (143Nd/144Nd or εNd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater εNd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive εNd data are also compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period (< 10,000 years). At water depths ≥ 1500 m, property-property plots show clear correlations between seawater εNd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater εNd distribution. At ≥ 200 m, basin-scale seawater T-S-εNd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive εNd values are compared using property-property plots and T-S-εNd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500 m) seawater data, we established empirical equations that predict the main, large-scale, deepwater εNd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive εNd is observed mainly within 1000 km from the continents. Generally, seawater and archive εNd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600 m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

Nadar.

1. Photographies / préface de Jean-François Bory; introduction aux photographies, choix des photos et rédaction des notices par Philippe Néagu (pour les arts et la musique) et Jean-Jacques Poulet-Allamagny (pour les lettres et les activités diverses).2. Dessins et écrits / introduction, notes et commentaires Jean-François BorySchoentjes, Pierr

Three Consecutive Pregnancies in a Patient with Chronic Autoimmune Thyroid Disease Associated with Hypothyroidism and Extremely High Levels of Anti-Thyrotropin Receptor Antibodies

International audienceBackground: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications. Patient Findings: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). At week 22 of her first pregnancy, sonography detected fetal growth retardation and cardiac abnormalities (extreme tachycardia, right ventricular dilatation, pericardial effusion). The mother's TRAb level, assayed later, was 4030 IU/L (n < 10). Delivered via caesarean section gestational week 30, the newborn girl had several malformations, signs of malnutrition, goiter and hyperthyroidism associated with elevated TRAb (1200 IU/L). The newborn died 26 days after delivery. Faced with persistently high TRAb levels and a desire to become pregnant again, the woman was treated with three consecutive 740-MBq activities of iodine-131, which resulted in a decrease in TRAb to 640 IU/L. The patient had two subsequent pregnancies 16 and 72 months after the radioiodine administration. During the close follow-ups, fetal development was normal, and initial TRAb levels during the two pregnancies were 680 and 260 IU/L, respectively, which initially decreased but then increased in late pregnancy. In both cases, labor was induced at 34 weeks. The newborns, mildly hyperthyroid at birth, required carbimazole treatment at days 5 and 2, respectively. The mild hyperthyroidism despite high TRAb levels was likely due to the concomitant presence of stimulating and blocking TRAb. The two girls, now aged 12 and 8 years, are in good health. The mother has no detectable thyroid gland tissue and is euthyroid on levothyroxine (175 μg/d). Her TRAb level gradually decreased to 136 IU/L. Summary and Conclusions: This remarkable case illustrates the severe consequences of untreated fetal hyperthyroidism and the need to assay and follow-up TRAb levels in women of reproductive age with autoimmune thyroiditis

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths

The large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records

International audienceThe large-scale evolution of neodymium isotopic composition in the global modern and Holocene ocean revealed from seawater data and other records. Kazuyo Tachikawa and project members Neodymium isotopic compositions (143 Nd/ 144 Nd or ε Nd) have been used as a tracer of water masses and lithogenic inputs to the ocean. To further evaluate the faithfulness of this tracer, we have updated a global seawater ε Nd database and combined it with hydrography parameters (temperature, salinity, nutrients and oxygen concentrations), carbon isotopic ratio and radiocarbon of dissolved inorganic carbon. Archive ε Nd data are compiled for leachates, foraminiferal tests, deep-sea corals and fish teeth/debris from the Holocene period. At water depths ≥ 1500m, property-property plots show clear correlations between seawater ε Nd and the other variables, suggesting that large-scale water mass mixing is a primary control of deepwater ε Nd distribution. At ≥ 200m, basin-scale seawater T-S-ε Nd diagrams demonstrate the isotopic evolution of different water masses. Seawater and archive ε Nd values are compared using property-property plots and T-S-ε Nd diagrams. Archive values generally agree with corresponding seawater values although they tend to be at the upper limit in the Pacific. Both positive and negative offsets exist in the northern North Atlantic. Applying multiple regression analysis to deep (≥ 1500m) seawater data, we established empirical equations that predict the main, large-scale, deepwater ε Nd trends from hydrography parameters. Large offsets from the predicted values are interpreted as a sign of significant local/regional influence. Dominant continental influence on seawater and archive ε Nd is observed mainly within 1,000 km from the continents. Generally, seawater and archive ε Nd values form gradual latitudinal trend in the Atlantic and Pacific at depths ≥ 600m, consistent with the idea that Nd isotopes help distinguish between northern/southern sourced water contributions at intermediate and deep water depths