RESENHA CRÍTICA DO LIVRO HERMENÊUTICA E EDUCAÇÃO DE NADJA HERMANN

Nádja Hermann a partir de sua prática como docente e pesquisadora da UFRGS, nos apresenta um texto no qual esclarece o significado da hermenêutica e o contexto filosófico em que esta se origina desde a mitologia grega aos nossos dias. É um texto com posicionamento explicito e provocativo que convoca ao debate e a reflexão, principalmente sobre as questões a cerca do processo de educar. Aponta a produtividade desse modo filosófico de pensar o mundo, dizendo que a hermenêutica pode oferecer uma contribuição valiosa às ciências humanas e também para a educação, sobretudo na medida em que permite um autoesclarecimento de suas bases teóricas e de suas contradições, e umarevisão dos limites das regras metodológicas impostas de forma única e definitiva como aparecem na pedagogia tradicional-cientificista. Faz uma aproximação reflexiva da educação a partir de suas possibilidades compreensivas reforçando que a educação é por excelência, o lugar do diálogo, portanto da palavra e da reflexão que ultrapassa a apropriação dos conhecimentos para nos conduzir a formação pessoal. Desde que podemos dizer a palavra, estamos em constante conversação com o mundo, instaurando a possibilidade de educar

Phytotoxic halimanes isolated from Baccharis salicifolia (Ruiz & Pad.) Pers.

From the EtOH extract of the medicinal native plant, Baccharis salicifolia, two novel halimane-type diterpenoids, salicifolic acid (1) and 5-hydroxy-6-hydro-salicifolic acid (2) together with the known compounds sakuranetin (3), apigenin (4) and scopoletin (5) were bioguided isolated against Panicum miliaceum (monocotyledonous). The structures of 1 and 2 were established by extensive spectroscopic analyses. The effective concentration for 50% inhibition of germination (ECg 50) and the root (ECr 50) and shoot (ECs 50) elongations was determined for 1-5 against P. miliaceum and Raphanus sativus (dicotyledonous). Compound 2 was the most active in the inhibition of germination of P. miliaceum (ECg 50 = 1 mM), followed by 1, 5 and 3, although 1 was the most effective in regulating the growth of P. miliaceum seedlings, with a ECr 50 and ECs 50 values of 1.8 and 6.6 mM, respectively. Compounds 1 and 3 were the only samples capable of inhibiting the germination of R. sativus, while seedling development was affected by 1, 2, and 3 with different effectiveness.Fil: del Corral, Soledad. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuffini, Silvia Lucia. Universidade Federal de Santa Catarina; Brasil. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cardoso, Simone G.. Universidade Federal de Santa Catarina; BrasilFil: Bortoluzzi, Adailton J.. Universidade Federal de Santa Catarina; BrasilFil: Palacios, Sara Maria. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentin

TRATAMENTO DA ESTOMATITE PROTÉTICA E IMPACTO SOBRE A QUALIDADE DE VIDA, HALITOSE, FLUXO E PH SALIVAR

A Estomatite Protética é uma infecção fúngica bucal presente em indivíduos portadores de prótese total. Na maioria dos casos, é assintomática, mas se apresenta influenciável quanto à qualidade de vida dos indivíduos portadores, à halitose, ao fluxo e ao pH salivar. O objetivo do presente trabalho foi verificar e comparar o efeito de duas terapias para o tratamento de EP. Para o grupo terapêutico 1 (G1) foi instituída a orientação de higiene padronizada com escova não dental, com a remoção da prótese durante o sono mantendo esta em solução contendo hipoclorito de sódio e o uso de bochecho com Digluconato de Clorexidine (DC) 0,12%, duas vezes ao dia. Para o grupo terapêutico 2 (G2) foi instituída a mesma terapia descrita para o G1 associada ao uso de uma formulação em gel de tintura de própolis, acondicionado diretamente sobre a prótese. A amostra foi composta por 20 pacientes distribuídos em 11 para o grupo de própolis (G2) e 9 para o controle (G1). Não houve diferença significante de idade dos participantes conforme o grupo terapêutico. Ambas as intervenções se mostraram eficazes na redução da área de infecção no palato (G1, p = 0,02/ G2 p = 0,003). A comparação entre os grupos quanto à redução da área afetada antes/depois mostrou não haver diferenças significantes entre ambos. A intervenção, independente do grupo terapêutico, mostrou impacto positivo sobre a qualidade de vida (p = 0,03). O presente estudo observou que o gel de própolis associado ao DC a 0,12% não foi melhor que o DC a 0,12% isolado; entretanto, o estudo também observou que a intervenção com ambas as terapias e a higiene orientada reduzem de forma significativa a área de infecção do palato com efeitos positivos sobre a qualidade de vida.Palavras-chave: Estomatite sob prótese. Própolis. Candida albicans. Prótese dentária

The use of Complementary and Alternative Medicine (CAM) among Italian children: A cross-sectional survey.

OBJECTIVE: To examine prevalence and modalities of CAM use in children living in Novara, a northern Italian city, and to estimate the prescription rate from paediatricians. METHOD: We administered a phone questionnaire to the parents of a sample of 147 children, asking questions about CAM use, children's health profile, parental socio-economic status, use modalities, effectiveness perceptions, and motivations. A parallel survey was conducted by e-mail by investigating family paediatricians attitudes about CAM. RESULTS: Among 147 children whose families responded to our survey 48.3% was treated with CAM at least once in life and 38,1% during the previous year. Children treated with CAM were on average younger than those who were not. The types of CAM used were herbal medicine and homeopathy. Parents who choose CAM for their children were more skeptical about vaccinations. CAM were most frequently used to treat pathologies of ear, nose and throat. 85.9% of parents was willing to use CAM in future, 78.9% would pass to conventional medicine if CAM failed. Among paediatricians 81.5% prescribed CAM at least once, but only 13.6% received specific CAM training. CONCLUSION: The prevalence of children using CAM in Novara is high, in line with investigations conducted in Northern European countries. The distribution of pathologies treated with CAM, parental socio-economic status and general scepticism towards vaccination are consistent with the literature. Physicians should keep themselves up-to-date also about evidence-based CAM therapies and, most importantly, should have an open dialogue about CAM with their patients

A constitutive active MAPK/ERK pathway due to BRAFV600E positively regulates AHR pathway in PTC

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor mediating the toxicity and tumor-promoting properties of dioxin. AHR has been reported to be overexpressed and constitutively active in a variety of solid tumors, but few data are currently available concerning its role in thyroid cancer. In this study we quantitatively explored a series of 51 paired-normal and papillary thyroid carcinoma (PTC) tissues for AHR-related genes. We identified an increased AHR expression/activity in PTC, independently from its nuclear dimerization partner and repressor but strictly related to a constitutive active MAPK/ERK pathway. The AHR up-regulation followed by an increased expression of AHR target genes was confirmed by a meta-analysis of published microarray data, suggesting a ligand-independent active AHR pathway in PTC. In-vitro studies using a PTC-derived cell line (BCPAP) and HEK293 cells showed that BRAF(V600E) may directly modulate AHR localization, induce AHR expression and activity in an exogenous ligand-independent manner. The AHR pathway might represent a potential novel therapeutic target for PTC in the clinical practice

Di-μ-chlorido-bis­{[2-({[2-(2-pyrid­yl)eth­yl](2-pyridylmeth­yl)amino}meth­yl)phenol]zinc(II)} bis­(perchlorate) dihydrate

The title compound, [Zn2Cl2(C20H21N3O)2](ClO4)2·2H2O, consists of a dinuclear ZnII cationic complex, two disordered perchlorate anions and two water mol­ecules as solvate. The [Zn2(μ-Cl)2(HL)2]2+ cation [HL is 2-({[2-(2-pyrid­yl)eth­yl](2-pyridylmeth­yl)amino}meth­yl)phenol] has a centrosymmetric structure with the ZnII ions in a distorted octa­hedral environment surrounded by an N3OCl2 donor set. HL acts as a tetra­dentate ligand through three N atoms from one amine group and two pyridyl arms and one O atom from the phenolic arm. The three N-donor sites of the HL ligand are arranged in meridional fashion, with the pyridine rings coordinated in trans positions with respect to each other. Consequently, the amine and phenol groups are trans to the asymmetric di-μ-chlorido exogenous bridges. A polymeric chain is formed along [010] by C(12)R 4 2(8) inter­molecular hydrogen bonding. The perchlorate anion is disordered and was modelled by two sites in a 0.345 (18):0.655 (18) ratio. Water–perchlorate O—H⋯O inter­actions form cyclic structures, while phenol–water O—H⋯O inter­actions generate an infinite chain. In addition, weak inter­molecular C—H⋯π(Ph) inter­actions between pyridine donor and phenol acceptor groups of neighboring cations build a two-dimensional polymeric structure parallel to (110)

Biologia reprodutiva de erva-mate (Ilex paraguariensis A. St. Hil) em remanescentes de Floresta Ombrófila Mista Altomontana

Information on the reproductive biology of species are key to planning land use guides and the conservation of forest resources. Thus, aspects of fl oral biology and breeding systems, flower visitors and the fruit development of Ilex paraguariensis A. St. Hil. were studied in an area of Mixed Ombrophylous Forest (Fazenda das Nascentes) in the city of Urupema, Santa Catarina state. For this study we monitored 161 individual adult erva mate (86 male and 75 female) plants during the period August 2011 to May 2012. The reproductive phenology showed 100 days, with peak flowering in the month of November and beginning of fruit ripening in May. The flowering of this species was recorded during periods of reduced precipitation and with an average temperature above 25°C. The flower visitors belonging to the orders Hymenoptera, Coleoptera, Hemiptera and Diptera visited the flowers during the day, during the period from 08:30 AM to 06:00 PM. The development of the fresh weight of the fruit increased quadratically. The results indicate the need for monitoring of reproductive individuals for a longer time which will allow more complete understanding of the reproductive cycle of erva mate in order to subsidize conservation strategies and management of this resource in the forest formations of Catarinense Highlands.Informações sobre a biologia reprodutiva de espécies são fundamentais para orientar planos de uso e conservação de recursos florestais. Desta forma, aspectos da biologia fl oral, visitantes florais e desenvolvimento do fruto de Ilex paraguariensis A. St. Hil. foram estudados em uma área da Floresta Ombrófi la Mista (Fazenda das Nascentes) no município de Urupema, SC. Para este estudo foram acompanhados 161 indivíduos adultos de erva-mate (86 masculinos e 75 femininos) no período de agosto de 2011 a maio 2012. A fenologia reprodutiva apresentou amplitude de 100 dias, com pico de floração no mês de novembro e início da maturação dos frutos em maio. A floração desta espécie foi registrada nos períodos de menor precipitação e de temperatura média acima de 25ºC. Os visitantes florais pertencentes às ordens Himenóptera, Coleóptera, Hemiptera e Díptera visitaram as flores durante o dia, no período das 08:30 as 18:00 h. O desenvolvimento dos frutos, com relação ao peso fresco aumentou de forma quadrática. Os resultados indicam a necessidade de um acompanhamento de indivíduos reprodutivos por maior tempo o que permitirá uma visão completa do ciclo reprodutivo da erva mate, para subsidiar estratégias de conservação e manejo adequado deste recurso nas formações florestais do Planalto Catarinense

Evaluation of Precision Livestock Technology and Human Scoring of Nursery Pigs in a Controlled Immune Challenge Experiment

The objectives were to determine the sensitivity, specificity, and cutoff values of a visual-based precision livestock technology (NUtrack), and determine the sensitivity and specificity of sickness score data collected with the live observation by trained human observers. At weaning, pigs (n = 192; gilts and barrows) were randomly assigned to one of twelve pens (16/pen) and treatments were randomly assigned to pens. Sham-pen pigs all received subcutaneous saline (3 mL). For LPS-pen pigs, all pigs received subcutaneous lipopolysaccharide (LPS; 300 µg/kg BW; E. coli O111:B4; in 3 mL of saline). For the last treatment, eight pigs were randomly assigned to receive LPS, and the other eight were sham (same methods as above; half-and-half pens). Human data from the day of the challenge presented high true positive and low false positive rates (88.5% sensitivity; 85.4% specificity; 0.871 Area Under Curve, AUC), however, these values declined when half-and-half pigs were scored (75% sensitivity; 65.5% specificity; 0.703 AUC). Precision technology measures had excellent AUC, sensitivity, and specificity for the first 72 h after treatment and AUC values were \u3e0.970, regardless of pen treatment. These results indicate that precision technology has a greater potential for identifying pigs during a natural infectious disease event than trained professionals using timepoint sampling

COVID-19 in rheumatic diseases in Italy: first results from the Italian registry of the Italian Society for Rheumatology (CONTROL-19)

OBJECTIVES: Italy was one of the first countries significantly affected by the coronavirus disease 2019 (COVID-19) epidemic. The Italian Society for Rheumatology promptly launched a retrospective and anonymised data collection to monitor COVID-19 in patients with rheumatic and musculoskeletal diseases (RMDs), the CONTROL-19 surveillance database, which is part of the COVID-19 Global Rheumatology Alliance. METHODS: CONTROL-19 includes patients with RMDs and proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) updated until May 3rd 2020. In this analysis, only molecular diagnoses were included. The data collection covered demographic data, medical history (general and RMD-related), treatments and COVID-19 related features, treatments, and outcome. In this paper, we report the first descriptive data from the CONTROL-19 registry. RESULTS: The population of the first 232 patients (36% males) consisted mainly of elderly patients (mean age 62.2 years), who used corticosteroids (51.7%), and suffered from multi-morbidity (median comorbidities 2). Rheumatoid arthritis was the most frequent disease (34.1%), followed by spondyloarthritis (26.3%), connective tissue disease (21.1%) and vasculitis (11.2%). Most cases had an active disease (69.4%). Clinical presentation of COVID-19 was typical, with systemic symptoms (fever and asthenia) and respiratory symptoms. The overall outcome was severe, with high frequencies of hospitalisation (69.8%), respiratory support oxygen (55.7%), non-invasive ventilation (20.9%) or mechanical ventilation (7.5%), and 19% of deaths. Male patients typically manifested a worse prognosis. Immunomodulatory treatments were not significantly associated with an increased risk of intensive care unit admission/mechanical ventilation/death. CONCLUSIONS: Although the report mainly includes the most severe cases, its temporal and spatial trend supports the validity of the national surveillance system. More complete data are being acquired in order to both test the hypothesis that RMD patients may have a different outcome from that of the general population and determine the safety of immunomodulatory treatments

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

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