Progettazione di un percorso di formazione professionale basato su Open Badge

Nell’era digitale, le istituzioni di istruzione e formazione professionale (IFP) sono emerse come ambienti di sviluppo trasformativi e flessibili; di conseguenza, è importante sviluppare opportunità di apprendimento professionale digitale che devono soddisfare i requisiti del mercato del lavoro europeo. Sono state condotte ricerche in merito a tali opportunità al fine di trovare nuovi strumenti per pianificare e condurre studi sul continuo sviluppo professionale e per raggiungere e mantenere le competenze versatili richieste nelle carriere di questi tempi. Questo studio mira a colmare un vuoto di ricerca riguardante lo sviluppo professionale avanzato basato sulle competenze, indagando il processo di apprendimento digitale aperto basato su badge nel contesto della formazione professionale. La domanda di ricerca considera come i badge digitali aperti strutturano il processo di apprendimento nel continuo sviluppo professionale delle nuove professioni pre e in servizio. La ricerca si è posta con l’obiettivo di esplorare le diverse idee, opinioni ed esperienze circa l’utilizzo di un sistema di badging all’interno di percorsi formativi professionali. Attraverso questo percorso si è sviluppata una comprensione profonda dei concetti e delle opportunità per il design di nuove pratiche educative. La domanda di ricerca ha esplorato il design di un percorso digitale di formazione professionale basato sull’applicazione delle logiche del gioco e di un sistema di micro-credentials. Ciò che è stato portato in evidenza è l’introduzione di cambiamenti necessari sia ai sistemi di erogazione, le piattaforme di e-learning, sia a quelli di gestione e pianificazione delle attività formative on line (gli LMS, Learning Management System) sia, infine al modo con cui vengono progettati e realizzati i corsi. La semplice sovrapposizione, come plug in, dei badge nelle piattaforme di e-learning, senza un adeguato progetto di cambiamento radicale del modo di fare formazione digitale, non produrrà i risultati sperati. La domanda generale di ricerca dello studio è la seguente: quali sono le best practice per il design di un percorso di formazione professionale basato open badge? L’entità dell’apprendimento digitale aperto basato su badge comprende materiali di apprendimento, criteri di badge, badge didattici, impalcature e supporto a tutti i corsisti. Questo studio offre approfondimenti sulla struttura del processo e la progettazione a più livelli per l’applicazione dell’approccio basato sulla Design based Research e badge digitali aperti e nello sviluppo professionale.In the digital age, vocational education and training (VET) institutions emerged as transformative and flexible development environments; consequently, it is important to develop digital professional learning opportunities which must meet the requirements of the European labor market. The research has been conducted into these opportunities, in order to find new tools for planning and conducting continuing professional development studies and for achieving and maintaining the versatile skills required in careers these days. This study aims to fill a research gap regarding advanced skills-based professional development by investigating the open badge-based digital learning process in the context of vocational training. The research question considers how open digital badges structure the learning process in the continuous professional development of new pre and in-service professions. The research was aimed to explore different ideas, opinions and experiences regarding the use of a badging system within professional training courses. Through this route we have developed an understanding wave of concepts and opportunities for the design of new educational practices. The research question explored the design of a digital vocational training course based on the application of the logic of the game and a system of micro-credentials. What has been highlighted is the introduction of necessary changes both to the delivery systems, the e-learning platforms, and to those for the management and planning of online training activities (the LMS, Learning Management System) and, finally, to the way in which the courses are designed and implemented. The simple overlapping, as a plug-in, of badges in e-learning platforms, without an adequate project of radical change in the way of doing digital training, will not produce the desired results. The firm's general research question is: “What are the best practices for designing an open badge- based career path” ? The entity of digital learning based on open badge includes learning materials, badge criteria, educational badge, scaffolding and support to all the participants . This study provides insights into the structure of the process and planning at various levels for the 'application of ' approach based on Design Research based and digital badge open and professional development

Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario

Antibiotic misuse is greatly contributing to an increase in antimicrobial resistance (AMR) in humans and animals. Natural and synthetic alternative strategies are being investigated in human and veterinary medicine, but little attention is paid to the antimicrobial effects of edible lipids, such as medium-chain fatty acids (MCFAs) and monoglycerides. Among MCFAs, lauric acid (LA) and its monoglyceride derivative, glycerol monolaurate (GML), exhibit the strongest antimicrobial activity. Coconut and palm kernel oils are considered the main sources of LA. On the other hand, some edible insects (e.g., Hermetia illucens) are gaining interest as novel feed ingredients, due to the high amount of LA they contain as well as their numerous bioactive components, which provide many additional benefits to animal health. Although the beneficial effect of both MCFAs and LA is gradually being recognized, their high content within insects and, consequently, their possible role as antimicrobials, has not been well-reported. This mini review focuses on the anti-infective effects of the insect-derived MCFAs LA and its derivatives. We emphasize the potential of insect lipids, compared to the other vegetable sources, in the current global scenario where a sustainable and circular economy is required. Finally, we critically discuss the use and the benefits of edible insects such as favorable options as feed and food from the perspective of animal and human nutrition

Dati demografici degli studenti e selezione dei MOOC su Eduopen. Uno studio esplorativo sui MOOC erogati da UniFg

Today's generation of Massive Open Online Courses (MOOC) based on Open EducationalResources (OER) is able to offer high quality education to all those who decide touse this new type of online lifelong learning. Students who decide to enroll in thesecourses represent an increasingly diverse audience in terms of age and place of origin.The literature is being enriched with research studies that study the demographic dataof the students in relation to different variables, including the type of course MOOCchosen.17 universities join the Eduopen project, including the University of Foggia, which in thefirst three years has contributed to the growth and development of the platform by designingand delivering various MOOCs, involving numerous teachers and stimulatingan increasing number of students from non-geographical areas. necessarily surrounding.Specifically, in April 2019 Unifg counts:– 34 Mooc Courses;– 4 Pathway;– 45 Lecturers and Tutors.– more than 8000 students.This contribution presents an exploratory study carried out on the demographic data ofthe students enrolled in the courses offered by the University of Foggia. Specifically, thedemographic data of the students were analyzed based on age, educational qualificationsand city of origin and studied the correlations between these data and the choiceof available courses.La generazione odierna di Massive Open Online Courses (MOOC) basati su Open Educational Resources (OER) è in grado di offrire un’istruzione di qualità a tutti coloro che, per varie ragioni, utilizzano questa nuova metodologia di formazione online. Gli studenti che decidono di iscriversi a questi corsi costituiscono un pubblico sempre più diversificato per quanto riguarda età e luogo di provenienza.I ricercatori, educatori, e il pubblico in generale recentemente si è interessato molto su come differisce la provenienza dei corsisti e sulla relazione tra questa variabile e la scelta di un corso MOOC. Al progetto Eduopen aderiscono 17 Atenei, tra cui l’Università di Foggia, che nel primo triennio ha contribuito alla crescita e sviluppo della piattaforma progettando ed erogando diversi MOOC, coinvolgendo numerosi docenti e stimolando un numero sempre più crescente di studenti provenienti da zone geografiche non necessariamente circostanti. Nello specifico, ad aprile 2019 UniFg conta:– 34 Corsi MOOC;– 4 Pathway;– 45 Docenti e Tutor.– più di 8000 studenti.Questo contributo presenta uno studio esplorativo effettuato sui dati demografici degli studenti iscritti ai corsi offerti dall’ateneo foggiano. Nello specifico, sono stati analizzati i dati demografici degli studenti in base a età, titolo di studio e città di provenienza e studiate le correlazioni tra questi dati e la scelta dei corsi disponibili

Macular Microcysts in Mitochondrial Optic Neuropathies: Prevalence and Retinal Layer Thickness Measurements.

PurposeTo investigate the thickness of the retinal layers and to assess the prevalence of macular microcysts (MM) in the inner nuclear layer (INL) of patients with mitochondrial optic neuropathies (MON).MethodsAll patients with molecularly confirmed MON, i.e. Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA), referred between 2010 and 2012 were enrolled. Eight patients with MM were compared with two control groups: MON patients without MM matched by age, peripapillary retinal nerve fiber layer (RNFL) thickness, and visual acuity, as well as age-matched controls. Retinal segmentation was performed using specific Optical coherence tomography (OCT) software (Carl Zeiss Meditec). Macular segmentation thickness values of the three groups were compared by one-way analysis of variance with Bonferroni post hoc corrections.ResultsMM were identified in 5/90 (5.6%) patients with LHON and 3/58 (5.2%) with DOA. The INL was thicker in patients with MON compared to controls regardless of the presence of MM [133.1±7μm vs 122.3±9μm in MM patients (p<0.01) and 128.5±8μm vs. 122.3±9μm in no-MM patients (p<0.05)], however the outer nuclear layer (ONL) was thicker in patients with MM (101.4±1mμ) compared to patients without MM [77.5±8mμ (p<0.001)] and controls [78.4±7mμ (p<0.001)]. ONL thickness did not significantly differ between patients without MM and controls.ConclusionThe prevalence of MM in MON is low (5-6%), but associated with ONL thickening. We speculate that in MON patients with MM, vitreo-retinal traction contributes to the thickening of ONL as well as to the production of cystic spaces

Plasma p-Cresol Lowering Effect of Sevelamer in Peritoneal Dialysis Patients: Evidence from a Cross-Sectional Observational Study.

p-Cresol is a by-product of the metabolism of aromatic aminoacid operated by resident intestinal bacteria. In patients with chronic kidney disease, the accumulation of p-cresol and of its metabolite p-cresyl-sulphate, that represents more than 95% of circulating p-cresol, causes endothelial dysfunction and ultimately increases the cardiovascular risk of these patients. Therapeutic strategies able to reduce plasma p-cresol levels are highly demanded but unfortunately not available yet. Because it has been reported that the phosphate binder sevelamer also sequesters p-cresol in vitro we hypothesized that it could do so also in peritoneal dialysis patients. To explore this hypothesis we measured total cresol plasma concentrations in 57 patients with end-stage renal disease on peritoneal dialysis patients, 29 receiving sevelamer for the treatment of hyperphosphatemia and 28 patients not assuming this drug. Among the patients not assuming sevelamer, 16 were treated with lanthanum whereas the remaining 12 received no drug because they were not hyperphosphatemic. When we compared total p-cresol plasma concentrations in these different groups of patients, we, we found that plasma p-cresol levels were significantly lower in patients receiving sevelamer than in subjects receiving lanthanum or no drug. Patients assuming sevelamer had also lower high sensitivity C-reactive protein serum concentrations compared to patients not assuming this drug. Multiple linear regression analysis showed that Conversely, no difference either in residual glomerular filtration rate, total weekly dialysis dose or serum phosphate levels were observed among the different groups. These results suggest that sevelamer could be an effective strategy to lower p-cresol circulating levels in peritoneal dialysis patients in which it could also favorably affect the cardiovascular risk because of its anti-inflammatory effect

Antimicrobial Resistance of Escherichia coli and Pseudomonas aeruginosa from Companion Birds

Antimicrobial resistance is a public health concern worldwide and it is largely attributed to the horizontal exchange of transferable genetic elements such as plasmids carrying integrons. Several studies have been conducted on livestock showing a correlation between the systemic use of antibiotics and the onset of resistant bacterial strains. In contrast, although companion birds are historically considered as an important reservoir for human health threats, little information on the antimicrobial resistance in these species is available in the literature. Therefore, this study was aimed at evaluating the antimicrobial resistance of Escherichia coli and Pseudomonas aeruginosa isolated from 755 companion birds. Cloacal samples were processed for E. coli and P. aeruginosa isolation and then all isolates were submitted to antimicrobial susceptibility testing. P. aeruginosa was isolated in 59/755 (7.8%) samples, whereas E. coli was isolated in 231/755 (30.7%) samples. Most strains showed multidrug resistance. This study highlights that companion birds may act as substantial reservoirs carrying antimicrobial resistance genes which could transfer directly or indirectly to humans and animals, and from a One Health perspective this risk should not be underestimated

Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication that integrates the gut and central nervous system (CNS) activities. Animal studies reveal that gut bacteria influence behaviour, Brain-Derived Neurotrophic Factor (BDNF) levels and serotonin metabolism. In the present study, we report for the first time an analysis of the microbiota–gut–brain axis in zebrafish (Danio rerio). After 28 days of dietary administration with the probiotic Lactobacillus rhamnosus IMC 501, we found differences in shoaling behaviour, brain expression levels of bdnf and of genes involved in serotonin signalling/metabolism between control and treated zebrafish group. In addition, in microbiota we found a significant increase of Firmicutes and a trending reduction of Proteobacteria. This study demonstrates that selected microbes can be used to modulate endogenous neuroactive molecules in zebrafish

Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish

The gut microbiota plays a crucial role in the bi-directional gut–brain axis, a communication that integrates the gut and central nervous system (CNS) activities. Animal studies reveal that gut bacteria influence behaviour, Brain-Derived Neurotrophic Factor (BDNF) levels and serotonin metabolism. In the present study, we report for the first time an analysis of the microbiota–gut–brain axis in zebrafish (Danio rerio). After 28 days of dietary administration with the probiotic Lactobacillus rhamnosus IMC 501, we found differences in shoaling behaviour, brain expression levels of bdnf and of genes involved in serotonin signalling/metabolism between control and treated zebrafish group. In addition, in microbiota we found a significant increase of Firmicutes and a trending reduction of Proteobacteria. This study demonstrates that selected microbes can be used to modulate endogenous neuroactive molecules in zebrafish

Probing the Binding Site of Abl Tyrosine Kinase Using in Situ Click Chemistry

Modern combinatorial chemistry is used to discover compounds with desired function by an alternative strategy, in which the biological target is directly involved in the choice of ligands assembled from a pool of smaller fragments. Herein, we present the first experimental result where the use of in situ click chemistry has been successfully applied to probe the ligand-binding site of Abl and the ability of this enzyme to form its inhibitor. Docking studies show that Abl is able to allow the in situ click chemistry between specific azide and alkyne fragments by binding to Abl-active sites. This report allows medicinal chemists to use protein-directed in situ click chemistry for exploring the conformational space of a ligand-binding pocket and the ability of the protein to guide its inhibitor. This approach can be a novel, valuable tool to guide drug design synthesis in the field of tyrosine kinases