Condensed and Updated Version of the Systematic Approach Meteorological Knowledge Base Southern Hemisphere

The meteorological knowledge base for the Systematic and Integrated Approach to Tropical Cyclone Track Forecasting proposed by Carr and Elsberry has evolved as additional research has been completed. As this Systematic Approach has been applied in the Southern Hemisphere, a number of conceptual models have been refined and new terminology has been adopted to reflect global applicability. As a knowledge-based expert system is being developed, it was convenient to condense and update the meteorological knowledge base for the Southern Hemisphere. Thus, the material is presented with text on the left page and the corresponding figure on the facing page as it will appear on the computer screen.Prepared for: Office of Naval Research, Code 322MM, Arlington, VA 22217 SPAWARSYSCOM, Code PMW 185, San Diego, CA 92110http://archive.org/details/condensedupdated00carrSponsored by: Office of Naval Research and SPAWARSYSCOM.Approved for public release; distribution is unlimited

Cleaning and Cleanliness Measurement of Additive Manufactured Parts

Additive Manufacturing processes allow for the manufacture of complex three dimensional components that otherwise could not be manufactured. Post treatment processes require the removal of any remnant bulk powder that may become entrapped within small cavities and channels within a component. This project focuses on several gross cleaning methods and the verification metrics associated with additive manufactured parts for oxygen propulsion usage

Pharmacokinetics of Single-Dose Oral Pregabalin Administration in Normal Cats

Objective: To describe the pharmacokinetic parameters of oral pregabalin in normal cats after single oral dosing.Animals: Six healthy adult research cats.Procedures: Following sedation and indwelling catheter placement, one oral (4 mg/kg) dose of pregabalin was administered. Blood samples were collected at 0, 15 and 30 min and 1, 1.5, 2, 3, 4, 6, 8, 12, 24, and 36 h after administration. Plasma pregabalin concentrations were measured by high-performance liquid chromatography and subjected to pharmacokinetic analysis using commercial software.Results: Four of six cats developed moderate sedation after pregabalin administration. The peak pregabalin concentration was 8.3 ± 1.6 μg/ml which occurred at 2.9 ± 1.2 h. Elimination half-life was 10.4 ± 2.6 h and area under the curve was 133.9 ± 71.5 μg-h/ml. Time above the minimum therapeutic concentration for seizure control in dogs and people (2.8 μg/ml) was 17.6 ± 6.2 h. Using these data, predicted minimum, maximum and average steady state concentrations were calculated for 12 and 24 h dosing intervals.Conclusions and Clinical Relevance: Pregabalin (4 mg/kg) administered orally to cats results in plasma concentrations within the range considered to be efficacious for seizure control in dogs and humans between 1.5 and at least 12 h. Because of moderate sedative side effects in the majority of cats at this dose and high calculated maximum steady state concentrations, a lower dose, given more frequently (1–2 mg/kg q 12 h), should be evaluated in prospective clinical studies

Particulate Matter (PM) Research Centers (1999–2005) and the Role of Interdisciplinary Center-Based Research

Objective: The U.S. Environmental Protection Agency funded five academic centers in 1999 to address the uncertainties in exposure, toxicity, and health effects of airborne particulate matter (PM) identified in the “Research Priorities for Airborne Particulate Matter” of the National Research Council (NRC). The centers were structured to promote interdisciplinary approaches to address research priorities of the NRC. In this report, we present selected accomplishments from the first 6 years of the PM Centers, with a focus on the advantages afforded by the interdisciplinary, center-based research approach. The review highlights advances in the area of ultrafine particles and traffic-related health effects as well as cardiovascular and respiratory effects, mechanisms, susceptibility, and PM exposure and characterization issues. Data sources and synthesis: The collective publications of the centers served as the data source. To provide a concise synthesis of overall findings, authors representing each of the five centers identified a limited number of topic areas that serve to illustrate the key accomplishments of the PM Centers program, and a consensus statement was developed. Conclusions: The PM Centers program has effectively applied interdisciplinary research approaches to advance PM science

On the existence of the logarithmic surface layer in the inner-core of hurricanes

Q. J. R. Meteorol. Soc., 1394128

Clinical development of new drug-radiotherapy combinations.

In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments. Notably, around 40% of cancer cures include the use of radiotherapy, either as a single modality or combined with other treatments. Radiotherapy can provide enormous benefit to patients with cancer. In the past decade, significant technical advances, such as image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic radiotherapy, and proton therapy enable higher doses of radiotherapy to be delivered to the tumour with significantly lower doses to normal surrounding tissues. However, apart from the combination of traditional cytotoxic chemotherapy with radiotherapy, little progress has been made in identifying and defining optimal targeted therapy and radiotherapy combinations to improve the efficacy of cancer treatment. The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) formed a Joint Working Group with representatives from academia, industry, patient groups and regulatory bodies to address this lack of progress and to publish recommendations for future clinical research. Herein, we highlight the Working Group's consensus recommendations to increase the number of novel drugs being successfully registered in combination with radiotherapy to improve clinical outcomes for patients with cancer.National Institute for Health ResearchThis is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/nrclinonc.2016.7

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Extension of the systematic approach to tropical cyclone track forecasting in the eastern and central North Pacific

This study extends an earlier study (White 1995) of the application of the Systematic Approach to tropical cyclone track forecasting of Carr and Elsberry to the eastern and central North Pacific, and contrasts these cases with those in the western North Pacific. The data sample is first expanded to seven years (1990-1996). Modifications to the environment structure conceptual models are: (1) introduction of two Dominant Ridge synoptic regions named Ridge Poleward and Ridge Equatorward based on the bowed orientation of the subtropical anticyclone; and (2) combining the Weak Westerlies and Accelerating Westerlies into just one synoptic region called Midlatitude Westerlies. Only eight synoptic pattern/region combinations are needed to classify all of the 1858 cases. Additions to the transitional mechanisms include: (1) the formation and dissipation of the mid-level low; (2) monsoon trough formation; and (3) orography. A new transition climatology reveals that a large fraction of transitions occur between the regions of the Standard pattern. Subtropical Ridge Modulation and Vertical Wind Shear are determined to be the most important transitional mechanisms. Synoptic analysis sequences are provided to illustrate the synoptic pattern/regions and the primary transitions.http://archive.org/details/extensionofsyste00bootCivilian, Naval Postgraduate School, Code MR/MbApproved for public release; distribution is unlimited

Beta test and development of a prototype dynamical model track prediction evaluation system model for the Atlantic

The U. S. Weather Research Program Hurricane Landfall has sponsored the Joint Hurricane Testbed program to facilitate a transition of research toward operations at the Tropical Prediction Center/National Hurricane Center (NHC). This paper describes the first-year effort during the 2001 hurricane season for producing a dynamical model expert system module for evaluating tropical cyclone track predictions in the Atlantic. This project is to adapt for use in the Atlantic a similar expert system for the western North Pacific that has been used successfully at the Joint Typhoon Warning Center, Hawaii.The original expert system was developed with funding from the Office of Naval Research Marine Meteorology Program and the Space and Naval Warfare Command. The US Weather Research Program has funded the adaptation to the Atlantic