Una vida y una obra dedicadas al estudio del sindicalismo argentino y latinoamericano : Entrevista a Julio Godio (In Memoriam 1939-2011)

Julio Godio es una figura intelectual clave para los estudios sobre temas sindicales y sobre la historia del movimiento obrero argentino. Estudió filosofía en la Universidad Nacional de La Plata. En la década de 1970 se exilió en Venezuela. Regresa definitivamente a Argentina, en 1994, luego de desplegar una extensa trayectoria en la Organización Internacional del Trabajo (OIT) entre 1986 y 1996. Fue autor de varias de las investigaciones más extensas existentes acerca de los movimientos obreros latinoamericanos, desarrollando además una extensa actividad periodística. Dirigió desde 1997 el Instituto del Mundo del Trabajo en Argentina, y fue miembro del consejo consultivo del Global Labour Institute.Departamento de Sociologí

Service design : contributions to understanding and improving the long lived user experience with ICT products and services

O uso de produtos e serviços de tecnologia da informação e comunicação (TIC) deixou de ser apenas uma opção de conforto para o usuário para tornar-se uma necessidade. Ainda assim, usuários idosos - grupo de cidadãos que se torna mais representativo a cada ano - não utiliza tais produtos e serviços tanto quanto poderia. A adoção de uma tecnologia depende não só das questões puramente técnicas envolvidas, mas de aspectos mais amplos, contextuais e sociais. Essa tese defende que o design de serviços poderia apoiar a compreensão e aprimoramento das experiências, de idosos saudáveis, com produtos e serviços de TIC a partir de uma investigação sociotécnica dos problemas. Para tanto, buscou-se conhecer e compreender a relevância de tais fatores, do sistema sociotécnico, afetando a experiência de uso de produtos e serviços de TIC em um estudo de caso conduzido em ambiente sociotécnico de TIC, com idosos que estiveram inseridos neste meio e outros participantes que ajudam os idosos em suas dificuldades com tecnologia. Com as evidências coletadas, utilizou-se o design de serviços para organizar as camadas de informações identificadas, classificá-las e apresentá-las com um olhar sistêmico. Os produtos gerados pelo estudo apoiam as fases de descoberta e priorização dos problemas do design, e facilitam o entendimento, validações, alinhamento de percepções e priorização de requisitos relevantes. Os resultados validam que o design de serviços apoia a compreensão de problemas complexos e suporta futuras intervenções de design, que venham a melhorar a experiência de usuários idosos com PSTIC.The use of information and communication technology products and services is no longer just a comfort option for the user to become a necessity. Even being more representative each year, elders does not use such products and services as much as they could. The adoption of a technology depends not only on the purely technical issues involved, but on broader, contextual and social aspects. This thesis argue that service design could support the understanding and improvement of experiences of healthy elderly people with ICT products and services based on a sociotechnical investigation of the problems. Therefore, it sought to know and understand the relevance of such factors, of the sociotechnical system, affecting the experience of using ICT products and services in a case study conducted in a sociotechnical environment of ICT, with elderly people who were inserted in this environment and other participants that help seniors with their technology struggles. With the evidence collected, it used service design to organize the layers of information identified, classify and present them with a systemic look. The products generated by the study support the discovery and prioritization phases of the design problems, and facilitate the understanding, validations, alignment of perceptions and prioritization of relevant requirements. The results validate that service design supports the understanding of complex problems and supports future design interventions that aim to improve the experience of elder users with PSTIC

Tendência temporal da precipitação pluvial anual do Rio Grande do Sul

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Una vida y una obra dedicadas al estudio del sindicalismo argentino y latinoamericano : Entrevista a Julio Godio (In Memoriam 1939-2011)

Julio Godio es una figura intelectual clave para los estudios sobre temas sindicales y sobre la historia del movimiento obrero argentino. Estudió filosofía en la Universidad Nacional de La Plata. En la década de 1970 se exilió en Venezuela. Regresa definitivamente a Argentina, en 1994, luego de desplegar una extensa trayectoria en la Organización Internacional del Trabajo (OIT) entre 1986 y 1996. Fue autor de varias de las investigaciones más extensas existentes acerca de los movimientos obreros latinoamericanos, desarrollando además una extensa actividad periodística. Dirigió desde 1997 el Instituto del Mundo del Trabajo en Argentina, y fue miembro del consejo consultivo del Global Labour Institute.Departamento de Sociologí

Una vida y una obra dedicadas al estudio del sindicalismo argentino y latinoamericano : Entrevista a Julio Godio (In Memoriam 1939-2011)

Fil: Del Bono, Andrea. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.Fil: Fernández Berdaguer, María Leticia. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina

Phase II pilot study of the prednisone to dexamethasone switch in metastatic castration-resistant prostate cancer (mCRPC) patients with limited progression on abiraterone plus prednisone (SWITCH study)

BACKGROUND: Despite most metastatic castration-resistant prostate cancer (mCRPC) patients benefit from abiraterone acetate plus prednisone 5 mg bid (AA + P), resistance eventually occurs. Long-term use of prednisone has been suggested as one of the mechanisms driving resistance, which may be reversed by switching to another steroid. METHODS: SWITCH was a single-arm, open-label, single-stage phase II study. The primary objective was to evaluate the antitumour activity of abiraterone acetate plus dexamethasone 0.5 mg daily (AA + D) in mCRPC patients progressing to AA + P. Clinically stable mCRPC patients who had prostate-specific antigen (PSA) and/or limited radiographic progression after at least 12 weeks on AA + P, were eligible. The primary endpoint was measured as the proportion of patients achieving a PSA decline of  ≥ 30% (PSA30) from baseline after 6 weeks on AA + D. Secondary endpoints included: PSA50 response rate at 12 weeks, time to biochemical and radiological progression, overall survival, safety profile evaluation, benefit from subsequent treatment lines and the identification of biomarkers of response (AR copy number, TMPRSS2-ERG status and PTEN expression). RESULTS: Twenty-six patients were enrolled. PSA30 and PSA50 were 46.2% and 34.6%, respectively. Median time to biochemical and radiological progression were 5.3 and 11.8 months, respectively. Two radiological responses were observed. Median overall survival was 20.9 months. Patients with AR gain detected in plasma circulating tumour DNA did not respond to switch, whereas patients with AR normal status benefited the most. No significant toxicities were observed and PSA50 response rate to subsequent taxane was 50%. CONCLUSIONS: In selected clinical stable mCRPC patients with limited disease progression on AA + P, a steroid switch from prednisone to dexamethasone can lead to PSA and radiological responses