Spacelab D-1 mission

The Spacelab D-1 (Deutchland Eins) Mission is discussed from the points of view of safety, materials handling, and toxic materials; the laboratory and equipment used; and some of the different philosophies utilized on this flight. How to enhance scientific return at the same time as being safe was examined

Panel summary of recommendations

The following Space Station internal contamination topics were addressed: past flight experience (Skylab and Spacelab missions); present flight activities (Spacelabs and Soviet Space Station Mir); future activities (materials science and life science experiments); Space Station capabilities (PPMS, FMS, ECLSS, and U.S. Laboratory overview); manned systems/crew safety; internal contamination detection; contamination control - stowage and handling; and contamination control - waste gas processing. Space Station design assumptions are discussed. Issues and concerns are discussed as they relate to (1) policy and management, (2) subsystem design, (3) experiment design, and (4) internal contamination detection and control. The recommendations generated are summarized

Photometry of the comet 2060 Chiron

The comet 2060 Chiron has proven to be an interesting and enigmatic object. Situated between the orbits of Saturn and Uranus, it was originally classified as the most distant asteroid. It began to show cometary behavior in 1987 by increasing a full magnitude in brightness and developing a coma; there is evidence also for similar earlier outbursts. A thorough study of Chiron is important for two reasons: (1) it is a transition object defining the relationship between comets, asteroids, and meteorites; and (2) a full description of its changes in brightness - particularly on time scale of hours - will provide an empirical foundation for understanding the physical mechanisms (including outgassing, sublimation of volatiles, and even significant mass ejections) driving the evolution of comets. Short term outbursts were observed in early 1989, and a rapid decrease in brightness of Chiron's coma was observed in 1990 in the V and R filters. Also, a rotational lightcurve was detected of the nucleus with an amplitude only 1/4 that observed in its quiescent state: this fact indicates the increased importance of the optically thin coma to the observed brightness

The microgravity environment of the Space Shuttle Columbia middeck during STS-32

Four hours of three-axis microgravity accelerometer data were successfully measured at the MA9F locker location in the Orbiter middeck of Columbia as part of the Microgravity Disturbances Experiment (MDE) on STS-32. These data were measured using the Honeywell In-Space Accelerometer, a small three-axis accelerometer that was hard-mounted onto the Fluid Experiment Apparatus to record the microgravity environment at the exact location of the MDE. Data were recorded during specific mission events such as Orbiter quiescent periods, crew exercise on the treadmill, and numerous Orbiter engine burns. Orbiter background levels were measured to be in the 3 x 10(exp -5) to 2 x 10(exp -4) G range, treadmill operations in the 6 x 10(exp -4) to 5 x 10(exp -3) G range, and Orbiter engine burns from 4 x 10(exp -3) to in excess of 1 x 10(exp -2) G. These data represent some of the first microgravity accelerometer data ever recorded in the middeck area of the Orbiter

The microgravity environment of the Space Shuttle Columbia payload bay during STS-32

Over 11 hours of three-axis microgravity accelerometer data were successfully measured in the payload bay of Space Shuttle Columbia as part of the Microgravity Disturbances Experiment on STS-32. These data were measured using the High Resolution Accelerometer Package and the Aerodynamic Coefficient Identification Package which were mounted on the Orbiter keel in the aft payload bay. Data were recorded during specific mission events such as Orbiter quiescent periods, crew exercise on the treadmill, and numerous Orbiter engine burns. Orbiter background levels were measured in the 10(exp -5) G range, treadmill operations in the 10(exp -3) G range, and the Orbiter engine burns in the 10(exp -2) G range. Induced acceleration levels resulting from the SYNCOM satellite deploy were in the 10 (exp -2) G range, and operations during the pre-entry Flight Control System checkout were in the 10(exp -2) to 10(exp -1) G range

PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models

SummaryPhosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We report on a potent oral PI3K-δ and PI3K-γ inhibitor (IPI-145) and characterize this compound in biochemical, cellular, and in vivo assays. These studies demonstrate that IPI-145 exerts profound effects on adaptive and innate immunity by inhibiting B and T cell proliferation, blocking neutrophil migration, and inhibiting basophil activation. We explored the therapeutic value of combined PI3K-δ and PI3K-γ blockade, and IPI-145 showed potent activity in collagen-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus rodent models. These findings support the hypothesis that inhibition of immune function can be achieved through PI3K-δ and PI3K-γ blockade, potentially leading to significant therapeutic effects in multiple inflammatory, autoimmune, and hematologic diseases

Gravitational Dose‐Response Curves for Acute Cardiovascular Hemodynamics and Autonomic Responses in a Tilt Paradigm

Background The cardiovascular system is strongly dependent on the gravitational environment. Gravitational changes cause mechanical fluid shifts and, in turn, autonomic effectors influence systemic circulation and cardiac control. We implemented a tilt paradigm to (1) investigate the acute hemodynamic response across a range of directions of the gravitational vector, and (2) to generate specific dose‐response relationships of this gravitational dependency. Methods and Results Twelve male subjects were tilted from 45° head‐up tilt to 45° head‐down tilt in 15° increments, in both supine and prone postures. We measured the steady‐state hemodynamic response in a range of variables including heart rate, stroke volume, cardiac output, oxygen consumption, total peripheral resistance, blood pressure, and autonomic indices derived from heart rate variability analysis. There is a strong gravitational dependence in almost all variables considered, with the exception of oxygen consumption, whereas systolic blood pressure remained controlled to within ≈3% across the tilt range. Hemodynamic responses are primarily driven by differential loading on the baroreflex receptors, combined with differences in venous return to the heart. Thorax compression in the prone position leads to reduced venous return and increased sympathetic nervous activity, raising heart rate, and systemic vascular resistance while lowering cardiac output and stroke volume. Conclusions Gravitational dose‐response curves generated from these data provide a comprehensive baseline from which to assess the efficacy of potential spaceflight countermeasures. Results also assist clinical management of terrestrial surgery in prone posture or head‐down tilt positions