49 research outputs found
Are the Mechanisms for Assessing the Quality of Training for Graduates of the Russian Penitentiary System Perfect?
The relevance of the study is due to the need to assess the quality of training of graduates of the Russian penitentiary system and the lack of an effective tool to assess the quality and level of training of graduates who have mastered professional educational programs at educational institutions of the Federal Penitentiary Service of Russia. In this regard, this article is aimed at identifying or disclosing mechanisms for evaluating the quality of educational services by independent experts, representatives of the employer, through professional and public accreditation of educational programs in educational institutions of the Federal Penitentiary Service of Russia. The leading methods to the study of this problem are general scientific methods (analysis, synthesis, analogy, generalization, etc.), which to introduce allow a comprehensive review of the procedure for professional and public accreditation of educational programs in the system of the Russian Federation. The article reveals the expected results of introducing the institution of professional public accreditation of educational programs in the Russian penitentiary system: improving the quality of the implemented educational programs, the level of organization of staff training, the quality and relevance of educational services, and the image of departmental services. The materials of the article are of practical value for improving the evaluation system of professional educational programs implemented in educational institutions of the Federal Penitentiary Service of Russia
Are the Mechanisms for Assessing the Quality of Training for Graduates of the Russian Penitentiary System Perfect?
The relevance of the study is due to the need to assess the quality of training of graduates of the Russian penitentiary system and the lack of an effective tool to assess the quality and level of training of graduates who have mastered professional educational programs at educational institutions of the Federal Penitentiary Service of Russia. In this regard, this article is aimed at identifying or disclosing mechanisms for evaluating the quality of educational services by independent experts, representatives of the employer, through professional and public accreditation of educational programs in educational institutions of the Federal Penitentiary Service of Russia. The leading methods to the study of this problem are general scientific methods (analysis, synthesis, analogy, generalization, etc.), which to introduce allow a comprehensive review of the procedure for professional and public accreditation of educational programs in the system of the Russian Federation. The article reveals the expected results of introducing the institution of professional public accreditation of educational programs in the Russian penitentiary system: improving the quality of the implemented educational programs, the level of organization of staff training, the quality and relevance of educational services, and the image of departmental services. The materials of the article are of practical value for improving the evaluation system of professional educational programs implemented in educational institutions of the Federal Penitentiary Service of Russia
Are the Mechanisms for Assessing the Quality of Training for Graduates of the Russian Penitentiary System Perfect?
The relevance of the study is due to the need to assess the quality of training of graduates of the Russian penitentiary system and the lack of an effective tool to assess the quality and level of training of graduates who have mastered professional educational programs at educational institutions of the Federal Penitentiary Service of Russia. In this regard, this article is aimed at identifying or disclosing mechanisms for evaluating the quality of educational services by independent experts, representatives of the employer, through professional and public accreditation of educational programs in educational institutions of the Federal Penitentiary Service of Russia. The leading methods to the study of this problem are general scientific methods (analysis, synthesis, analogy, generalization, etc.), which to introduce allow a comprehensive review of the procedure for professional and public accreditation of educational programs in the system of the Russian Federation. The article reveals the expected results of introducing the institution of professional public accreditation of educational programs in the Russian penitentiary system: improving the quality of the implemented educational programs, the level of organization of staff training, the quality and relevance of educational services, and the image of departmental services. The materials of the article are of practical value for improving the evaluation system of professional educational programs implemented in educational institutions of the Federal Penitentiary Service of Russia
Congenital heart disease risk loci identified by genome-wide association study in European patients
Genetic factors undoubtedly affect the development of congenital heart disease (CHD) but still remain ill defined. We sought to identify genetic risk factors associated with CHD and to accomplish a functional analysis of SNP-carrying genes. We performed a genome-wide association study (GWAS) of 4034 White patients with CHD and 8486 healthy controls. One SNP on chromosome 5q22.2 reached genome-wide significance across all CHD phenotypes and was also indicative for septal defects. One region on chromosome 20p12.1 pointing to the MACROD2 locus identified 4 highly significant SNPs in patients with transposition of the great arteries (TGA). Three highly significant risk variants on chromosome 17q21.32 within the GOSR2 locus were detected in patients with anomalies of thoracic arteries and veins (ATAV). Genetic variants associated with ATAV are suggested to influence the expression of WNT3, and the variant rs870142 related to septal defects is proposed to influence the expression of MSX7. We analyzed the expression of all 4 genes during cardiac differentiation of human and murine induced pluripotent stem cells in vitro and by single-cell RNA-Seq analyses of developing murine and human hearts. Our data show that MACROD2, GOSR2, WNT3, and MSX7 play an essential functional role in heart development at the embryonic and newborn stages
Akkermansia muciniphila - friend or foe in colorectal cancer?
Akkermansia muciniphila is a gram-negative anaerobic bacterium, which represents a part of the commensal human microbiota. Decline in the abundance of A. muciniphila among other microbial species in the gut correlates with severe systemic diseases such as diabetes, obesity, intestinal inflammation and colorectal cancer. Due to its mucin-reducing and immunomodulatory properties, the use of probiotics containing Akkermansia sp. appears as a promising approach to the treatment of metabolic and inflammatory diseases. In particular, a number of studies have focused on the role of A. muciniphila in colorectal cancer. Of note, the results of these studies in mice are contradictory: some reported a protective role of A. muciniphila in colorectal cancer, while others demonstrated that administration of A. muciniphila could aggravate the course of the disease resulting in increased tumor burden. More recent studies suggested the immunomodulatory effect of certain unique surface antigens of A. muciniphila on the intestinal immune system. In this Perspective, we attempt to explain how A. muciniphila contributes to protection against colorectal cancer in some models, while being pathogenic in others. We argue that differences in the experimental protocols of administration of A. muciniphila, as well as viability of bacteria, may significantly affect the results. In addition, we hypothesize that antigens presented by pasteurized bacteria or live A. muciniphila may exert distinct effects on the barrier functions of the gut. Finally, A. muciniphila may reduce the mucin barrier and exerts combined effects with other bacterial species in either promoting or inhibiting cancer development
Domination, core and solution
Bondareva O. Domination, core and solution. Working Papers. Institute of Mathematical Economics. Vol 185. Bielefeld: Center for Mathematical Economics; 1990
The nucleolus of a game without side payments
Bondareva O. The nucleolus of a game without side payments. Working Papers. Institute of Mathematical Economics. Vol 176. Bielefeld: Center for Mathematical Economics; 1989
Preservation of the Shor Language of the Small People of Kuzbass as a Component of Russian Coal Cluster Sustainable Development
The Shor are a small indigenous people of Western Siberia. In total, there are 13 thousand representatives of this nation in the world. The ethnos was formed in the 6-9 centuries. Kuzbass – the largest coal cluster in Russia – is a home for a significant part of the Shor population, being the indigenous minority of the region. The development of mining operations (mainly coal and iron ore mining) negatively affects the territory of the Shor people habitation. Therefore, the preservation of their cultural traditions, including the original language, is an important part of the sustainable development of the mining region Kuzbass. The suggested study is based on the Shor language material, which belongs to the Turkic branch of the Altai language family. The purpose of the study is to describe the synthetic type of complex sentences in the Shor language, which is designed to help preserve their culture in the system of sustainable development of Kuzbass
Vascular Homeostasis and Inflammation in Health and Disease—Lessons from Single Cell Technologies
The vascular system is critical infrastructure that transports oxygen and nutrients around
the body, and dynamically adapts its function to an array of environmental changes. To fulfil the
demands of diverse organs, each with unique functions and requirements, the vascular system
displays vast regional heterogeneity as well as specialized cell types. Our understanding of the
heterogeneity of vascular cells and the molecular mechanisms that regulate their function is beginning
to benefit greatly from the rapid development of single cell technologies. Recent studies have started
to analyze and map vascular beds in a range of organs in healthy and diseased states at single
cell resolution. The current review focuses on recent biological insights on the vascular system
garnered from single cell analyses. We cover the themes of vascular heterogeneity, phenotypic
plasticity of vascular cells in pathologies such as atherosclerosis and cardiovascular disease, as well
as the contribution of defective microvasculature to the development of neurodegenerative disorders
such as Alzheimer’s disease. Further adaptation of single cell technologies to study the vascular
system will be pivotal in uncovering the mechanisms that drive the array of diseases underpinned by
vascular dysfunction