SARS-CoV-2: Current Perspective on Control, Prevention, and Therapeutic Promise

Background: The novel coronavirus disease (COVID-19) outbreak has halted activities throughout the globe because of its rapid spread. COVID-19  is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a β-coronavirus first detected in China. SARS-CoV-2 has been implicated to be transmitted via direct contact, fomite, respiratory droplets, and possibly aerosol. The spread of the disease is complicated due to the slow onset of symptoms and asymptomatic infected patients. Methods: This narrative communication summarizes the recent researches sourced using sensitive search strategies to identify COVID-19 current perspectives on the control, prevention, and therapeutic promise. Result: Several strategies and multiple control measures have been implemented around the globe to contain COVID-19. Considering the   exponential spread of the pandemic, several scientists and physicians have been racing to discover possible therapeutics and vaccines for COVID-19. There are clinical trials to investigate the vaccine designed to protect against the infection and also to substantiate the claim made for BCG protection against COVID-19. Although, there is currently no universally approved medication to treat SARS-CoV-2, there have been random reports of existing medications ameliorating the infection, and these regimens are still under clinical trial. There is also the potential therapeutic prospect of rhinothermy to fight SARS-CoV-2 judging from its success in fighting upper respiratory tract viral infection. Conclusion: The information provided in this communication gives a reliable intellectual grounding regarding the current perspective on COVID-19  control, progress made in the development of vaccines and therapeutic regimen, and where future research in this area should be focused. Keywords: COVID-19; SARS-CoV-2; control; WHO; respiratory; cases; trac

A conceptual framework for evaluating cooking systems

PUBLISHED 7 March 2022Tami C Bond, Christian L, Orange, Paul R Medwell, George Sizoomu, Samer Abdelnour, Verena Brinkmann, Philip Lloyd and Crispin Pemberton-Pigot

Cross-correlating Carbon Monoxide Line-intensity Maps with Spectroscopic and Photometric Galaxy Surveys

Line-intensity mapping (LIM or IM) is an emerging field of observational work, with strong potential to fit into a larger effort to probe large-scale structure and small-scale astrophysical phenomena using multiple complementary tracers. Taking full advantage of such complementarity means, in part, undertaking line-intensity surveys with galaxy surveys in mind. We consider the potential for detection of a cross-correlation signal between COMAP and blind surveys based on photometric redshifts (as in COSMOS) or based on spectroscopic data (as with the HETDEX survey of Lyman-$\alpha$ emitters). We find that obtaining $\sigma_z/(1+z)\lesssim0.003$ accuracy in redshifts and $\gtrsim10^{-4}$ sources per Mpc$^3$ with spectroscopic redshift determination should enable a CO-galaxy cross spectrum detection significance at least twice that of the CO auto spectrum. Either a future targeted spectroscopic survey or a blind survey like HETDEX may be able to meet both of these requirements.Comment: 19 pages + appendix (31 pages total), 16 figures, 6 tables; accepted for publication in Ap

A New Dark Matter Candidate: Non-thermal Sterile Neutrinos

We propose a new and unique dark matter candidate: $\sim 100$ eV to $\sim 10$ keV sterile neutrinos produced via lepton number-driven resonant MSW (Mikheyev-Smirnov-Wolfenstein) conversion of active neutrinos. The requisite lepton number asymmetries in any of the active neutrino flavors range from 10$^{-3}$ to 10$^{-1}$ of the photon number - well within primordial nucleosynthesis bounds. The unique feature here is that the adiabaticity condition of the resonance strongly favors the production of lower energy sterile neutrinos. The resulting non-thermal (cold) energy spectrum can cause these sterile neutrinos to revert to non-relativistic kinematics at an early epoch, so that free-streaming lengths at or below the dwarf galaxy scale are possible. Therefore, the main problem associated with light neutrino dark matter candidates can be circumvented in our model.Comment: Latex 11 pages + 1 figur

Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C

Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and appropriate adjuvants. As previously established, the genome of DBA/2J mice encodes genes that are capable of conferring dominant resistance to EAO, while the genome of BALB/cByJ mice does not and they are therefore susceptible to EAO. In a genome scan, we previously identified Orch3 as the major quantitative trait locus controlling dominant resistance to EAO and mapped it to chromosome 11. Here, by utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3. Mechanistically, we showed that the resistant Kif1c$^{D2}$ allele leads to a reduced antigen-specific T cell proliferative response as a consequence of decreased MHC class II expression by antigen presenting cells, and that the L$^{578}$→P$^{578}$ and S$^{1027}$→P$^{1027}$ polymorphisms distinguishing the BALB/cByJ and DBA/2J alleles, respectively, can play a role in transcriptional regulation. These findings may provide mechanistic insight into how polymorphism in other kinesins such as KIF21B and KIF5A influence susceptibility and resistance to human autoimmune diseases

Confirmation of SBS 1150+599A As An Extremely Metal-Poor Planetary Nebula

SBS 1150+599A is a blue stellar object at high galactic latitude discovered in the Second Byurakan Survey. New high-resolution images of SBS 1150+599A are presented, demonstrating that it is very likely to be an old planetary nebula in the galactic halo, as suggested by Tovmassian et al (2001). An H-alpha image taken with the WIYN 3.5-m telescope and its "tip/tilt" module reveals the diameter of the nebula to be 9.2", comparable to that estimated from spectra by Tovmassian et al. Lower limits to the central star temperature were derived using the Zanstra hydrogen and helium methods to determine that the star's effective temperature must be > 68,000K and that the nebula is optically thin. New spectra from the MMT and FLWO telescopes are presented, revealing the presence of strong [Ne V] lambda 3425, indicating that the central star temperature must be > 100,000K. With the revised diameter, new central star temperature, and an improved central star luminosity, we can constrain photoionization models for the nebula significantly better than before. Because the emission-line data set is sparse, the models are still not conclusive. Nevertheless, we confirm that this nebula is an extremely metal-poor planetary nebula, having a value for O/H that is less than 1/100 solar, and possibly as low as 1/500 solar.Comment: 19 pages, 6 figures. Accepted for publication in the Astronomical Journa

The Cosmology of Asymmetric Brane Modified Gravity

We consider the asymmetric branes model of modified gravity, which can produce late time acceleration of the universe and compare the cosmology of this model to the standard $\Lambda$CDM model and to the DGP braneworld model. We show how the asymmetric cosmology at relevant physical scales can be regarded as a one-parameter extension of the DGP model, and investigate the effect of this additional parameter on the expansion history of the universe.Comment: 21 pages, 9 figures, journal versio

Testing Inflation with Large Scale Structure: Connecting Hopes with Reality

The statistics of primordial curvature fluctuations are our window into the period of inflation, where these fluctuations were generated. To date, the cosmic microwave background has been the dominant source of information about these perturbations. Large scale structure is however from where drastic improvements should originate. In this paper, we explain the theoretical motivations for pursuing such measurements and the challenges that lie ahead. In particular, we discuss and identify theoretical targets regarding the measurement of primordial non-Gaussianity. We argue that when quantified in terms of the local (equilateral) template amplitude $f_{\rm NL}^{\rm loc}$ ($f_{\rm NL}^{\rm eq}$), natural target levels of sensitivity are $\Delta f_{\rm NL}^{\rm loc, eq.} \simeq 1$. We highlight that such levels are within reach of future surveys by measuring 2-, 3- and 4-point statistics of the galaxy spatial distribution. This paper summarizes a workshop held at CITA (University of Toronto) on October 23-24, 2014.Comment: 27 pages + reference

Sustainability appraisal: Jack of all trades, master of none?

Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development. We suggest that the inherent flexibility of sustainability appraisal facilitates outcomes that often do not adhere to the three goals enshrined in most definitions of sustainable development: economic growth, environmental protection and enhancement, and the wellbeing of the human population. Current practice is for sustainable development to be disenfranchised through the interpretation of sustainability, whereby the best alternative is good enough even when unsustainable. Practitioners must carefully and transparently review the frameworks applied during sustainability appraisal to ensure that outcomes will meet the three goals, rather than focusing on a discourse that emphasises one or more goals at the expense of the other(s)