Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines

Miniaturization and acceleration of synthetic chemistry is an emerging area in pharmaceutical, agrochemical, and materials research and development. Herein, we describe the synthesis of iminopyrrolidine-2-carboxylic acid derivatives using chiral glutamine, oxo components, and isocyanide building blocks in an unprecedented Ugi-3-component reaction. We used I-DOT, a positive-pressure-based low-volume and non-contact dispensing technology to prepare more than 1000 different derivatives in a fully automated fashion. In general, the reaction is stereoselective, proceeds in good yields, and tolerates a wide variety of functional groups. We exemplify a pipeline of fast and efficient nanomole-scale scouting to millimole-scale synthesis for the discovery of a useful novel reaction with great scope

NACA Research Memorandums

Report presenting pressure measurements on a semispan model of a cambered and twisted wing, alone and in combination with a fuselage. The wing had 40 degrees of sweepback, an aspect ratio of 10, a taper ratio of 0.4, and 5 degrees of washout at the tip. Results regarding the pressure distribution and flow separation, section characteristics, and span loading characteristics are provided

CCDC 1940862: Experimental Crystal Structure Determination

Related Article: Angelina Osipyan, Shabnam Shaabani, Robert Warmerdam, Svitlana V. Shishkina, Harry Boltz, Alexander Dömling|2020|Angew.Chem.,Int.Ed.|59|12423|doi:10.1002/anie.20200088