Recomendaciones para el espumado de PVC

Se exponen los diferentes procesos, aplicaciones de productos espumados y la formulación del PVC; teniendo en cuenta las modificaciones en la reología del fundido, la concentración del espumante o las condiciones de refrigeración, tienen el efecto sobre el proceso de espumado y las propiedades físicas del producto final

Moj priročnik in dnevnik za zdravljenje z nintedanibom

Zdravilo nintedanib se uporablja pri zdravljenju žleznega raka pljuč (adenokarcinom), pogoste oblike raka na pljučih, ko trenutno zdravljenje ni več primerno. S pomočjo te knjižice se lahko bolje poučite o tem, kako zdravilo deluje in kaj pričakovati, medtem ko ga jemljete

Time for gender mainstreaming in editorial policies

The HIV epidemic has been continuously growing among women, and in some parts of the world, HIV-infected women outnumber men. Women's greater vulnerability to HIV, both biologically and socially, influences their health risk and health outcome. This disparity between sexes has been established for other diseases, for example, autoimmune diseases, malignancies and cardiovascular diseases. Differences in drug effects and treatment outcomes have also been demonstrated

Effect of tiotropium on COPD exacerbations: A systematic review

Exacerbation frequency is related to disease progression, quality of life, and prognosis in COPD. Earlier diagnosis, along with interventions aimed at preventing exacerbations and delaying progression, may help reduce the global burden of disease. Long-acting inhaled bronchodilators are effective at maintaining symptom relief and are recommended as first-choice therapy for more symptomatic patients and those at risk of exacerbation.This article is freely available via Open Access. Click on the 'Additional Link' above to access the full-text from the publisher's site.Published (Open Access

Pathways for outpatient management of venous thromboembolism in a UK centre.

It has become widely recognised that outpatient treatment may be suitable for many patients with venous thromboembolism. In addition, non-vitamin K antagonist oral anticoagulants that have been approved over the last few years have the potential to be an integral component of the outpatient care pathway, owing to their oral route of administration, lack of requirement for routine anticoagulation monitoring and simple dosing regimens. A robust pathway for outpatient care is also vital; one such pathway has been developed at Sheffield Teaching Hospitals in the UK. This paper describes the pathway and the arguments in its favour as an example of best practice and value offered to patients with venous thromboembolism. The pathway has two branches (one for deep vein thrombosis and one for pulmonary embolism), each with the same five-step process for outpatient treatment. Both begin from the point that the patient presents (in the Emergency Department, Thrombosis Clinic or general practitioner's office), followed by diagnosis, risk stratification, treatment choice and, finally, follow-up. The advantages of these pathways are that they offer clear, evidence-based guidance for the identification, diagnosis and treatment of patients who can safely be treated in the outpatient setting, and provide a detailed, stepwise process that can be easily adapted to suit the needs of other institutions. The approach is likely to result in both healthcare and economic benefits, including increased patient satisfaction and shorter hospital stays

Skin cancer and Parkinson’s disease

© 2010 Movement Disorder Society [The definitive version is available at www3.interscience.wiley.com] - [A versão definitiva está disponível em www3.interscience.wiley.com]The report of an increased frequency of melanoma during the clinical development of rasagiline prompted a renewed interest in a possible association between skin cancer and Parkinson's disease (PD). The evaluation of this risk ended in a recommendation to perform a periodic dermatological examination as a follow-up measure of their treatment. The recognition of this safety concern lead to the need to clarify if the risk of skin cancer is indeed associated with PD and if levodopa or other anti-parkinsonian drugs might contribute to increase such risk. To answer these questions, we critically reviewed all clinical studies available concerning the association between skin cancer and PD. We found 26 studies on cancer occurrence in PD. The best data available suggest the risk of cancer is reduced in PD patients. However, specific cancers like thyroid and the female breast were reported at higher-than-expected rates. Additionally, it was suggested that PD patients have a higher frequency of melanoma and non-melanoma skin cancers than the general population. The data on non-melanoma skin cancer are less robust than the data on melanoma. Causal factors remain unknown. Due to the weak association between skin cancer and PD, no robust recommendation can be made regarding the need for periodic dermatological screening.Financial Disclosure: In the past 12 months, the authors have the following information to disclose. Joaquim Ferreira, Consultancies: TEVA, Lundbeck, Ipsen, Solstice, Novartis, GlaxoSmithKline, Solvay, Grunenthal, BIAL; Advisory Boards: GlaxoSmithKline, Novartis, TEVA, Lundbeck, Allergan, Solvay, BIAL. Mário Rosa, Honoraria: Tecnifar, Grunenthal. Olivier Rascol: Consultancies: Boehringer Ingelheim, Eisai, GlaxosmithKline, Novartis, Schering, Solvay, Teva Neuroscience, Lundbeck and UCB; Grants: Boehringer Ingelheim, Eisai, GlaxosmithKline, Novartis, Solvay, Teva Neuroscience and Lundbeck. Cristina Sampaio, Consultancies: In all cases the fees / honoraria due are paid to department and not received personally: Lundbeck, Abbott, Bial, Boeringher -LMS Group Schering-Plough, Solvay

PharmaSUG 2012 -Paper DS06 SDTM Domain Mapping with Structured Programming Methodology

ABSTRACT This paper describes the implementation of SDTM domain mapping with structured programming methodology. Structured design and structured programming make our mapping codes easy to implement, understand, debug, and maintain. Example codes for domain mapping are provided, with which the readers can easily adapt to meet their mapping requirements