1,428 research outputs found
Pasos Hacia La Salud: a randomized controlled trial of an internet-delivered physical activity intervention for Latinas.
BackgroundInternet access has grown markedly in Latinos during the past decade. However, there have been no Internet-based physical activity interventions designed for Latinos, despite large disparities in lifestyle-related conditions, such as obesity and diabetes, particularly in Latina women. The current study tested the efficacy of a 6-month culturally adapted, individually tailored, Spanish-language Internet-based physical activity intervention.MethodsInactive Latinas (N = 205) were randomly assigned to the Tailored Physical Activity Internet Intervention or the Wellness Contact Control Internet Group. Participants in both groups received emails on a tapered schedule over 6 months to alert them to new content on the website. The primary outcome was minutes/week of moderate to vigorous physical activity (MVPA) at 6 months as measured by the 7-Day Physical Activity Recall; activity was also measured by accelerometers. Data were collected between 2011 and 2014 and analyzed in 2015 at the University of California, San Diego.ResultsIncreases in minutes/week of MVPA were significantly greater in the Intervention Group compared to the Control Group (mean difference = 50.00, SE = 9.5, p < 0.01). Increases in objectively measured MVPA were also significantly larger in the Intervention Group (mean differences = 31.0, SE = 10.7, p < .01). The Intervention Group was also significantly more likely to meet national physical activity guidelines at 6 months (OR = 3.12, 95% CI 1.46-6.66, p < .05).ConclusionFindings from the current study suggest that this Internet-delivered individually tailored intervention successfully increased MVPA in Latinas compared to a Wellness Contact Control Internet Group.Trial registrationNCT01834287
Personalized web learning: merging Open Educational Resources into adaptive courses for higher education
In this paper, educational and technical challenges for applying learning pathways in Massive(ly) Open Online Courses in higher education are outlined. The authors argue that quality issues and didactical concerns may be overcome by (1) reverting to small Open Educational Resources that are (2) adaptively joined into concise courses by considering (3) predefined learning pathways with proper semantic annotations and (4) the observation of learner behaviour. Such a merger does not only require conceptual work and corresponding support tools, but also a new meta data format and an engine which interprets the semantic annotations as well as the measures of learner’s actions. These factors are then turned into didactically meaningful recommendations for the next learning steps, thereby creating a personalized learning pathway for each learner. The EU FP7 project INTUITEL is introduced, which has already contributed to the conceptual work and is currently developing the software to achieve these tasks. (DIPF/Orig.
Stronger response of farmland birds than farmers to climate change leads to the emergence of an ecological trap
Climate change is triggering adaptation by people and wildlife. The speed and magnitude of these responses may disrupt ecological equilibria and potentially cause further biodiversity losses, but this has rarely been studied. Species inhabiting human-dominated landscapes may be particularly negatively affected by human adaptations to climate change. This could be, for example, the case of ground-nesting farmland birds, a group of highly vulnerable species that may be impacted by shifts in the timing of mechanical farming operations in response to climate change. Here we aim to explore whether trends in phenology of breeding ground-nesting birds differ from those of farming practices, and whether differences lead to the emergence of phenological mistiming with detrimental consequences to the birds. To achieve our objective, we tan linear mixed effects models using a 38 year dataset on onset of farming practices (i.e. sowing dates) and laying date of two endangered ground-nesting farmland birds (Northern lapwing and Eurasian curlew) in Finland. We found that timing of farming practices advanced slower than birds nesting phenology, with birds progressively starting nesting before fields are sown. These nests are at high risk of destruction from incoming sowing operations. The results highlight the importance of considering human adaptation responses, in addition to those of wildlife, for implementing species conservation in managed landscapes under climate change.Peer reviewe
Spectral behavior of thin film coated cascaded tapered long period gratings in multiple configurations
In this work the spectral response of cascaded tapered long period gratings coated by nano-sized polymeric films has been investigated as function of the surrounding medium refractive index (SRI). The investigation was aimed to identify the best configuration in terms of coated/not coated areas in order to fully benefit of the SRI sensitivity enhancement due to the modal transition mechanism of nano-coated long period gratings while preserving the fringes visibility
A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in Streptococcus sanguis. To reveal this stalling mechanism we obtained 3.6-angstrom-resolution cryo-EM structures of ErmBL-stalled ribosomes with erythromycin. The nascent peptide adopts an unusual conformation with the C-terminal Asp10 side chain in a previously unseen rotated position. Together with molecular dynamics simulations, the structures indicate that peptide-bond formation is inhibited by displacement of the peptidyl-tRNA A76 ribose from its canonical position, and by non-productive interactions of the A-tRNA Lys11 side chain with the A-site crevice. These two effects combine to perturb peptide-bond formation by increasing the distance between the attacking Lys11 amine and the Asp10 carbonyl carbon. The interplay between drug, peptide and ribosome uncovered here also provides insight into the fundamental mechanism of peptide-bond formation
Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson’s disease
Gamma synchronization increases during movement and scales with kinematic
parameters. Here, disease-specific characteristics of this synchronization and
the dopamine-dependence of its scaling in Parkinson’s disease are
investigated. In 16 patients undergoing deep brain stimulation surgery,
movements of different velocities revealed that subthalamic gamma power peaked
in the sensorimotor part of the subthalamic nucleus, correlated positively
with maximal velocity and negatively with symptom severity. These effects
relied on movement-related bursts of transient synchrony in the gamma band.
The gamma burst rate highly correlated with averaged power, increased
gradually with larger movements and correlated with symptom severity. In the
dopamine-depleted state, gamma power and burst rate significantly decreased,
particularly when peak velocity was slower than ON medication. Burst amplitude
and duration were unaffected by the medication state. We propose that
insufficient recruitment of fast gamma bursts during movement may underlie
bradykinesia as one of the cardinal symptoms in Parkinson’s disease
Atmospheric phase correction using CARMA-PACS: high angular resolution observations of the FU Orionis star PP 13S*
We present 0".15 resolution observations of the 227 GHz continuum emission from the circumstellar disk around
the FU Orionis star PP 13S*. The data were obtained with the Combined Array for Research in Millimeter-wave
Astronomy (CARMA) Paired Antenna Calibration System (C-PACS), which measures and corrects the atmospheric
delay fluctuations on the longest baselines of the array in order to improve the sensitivity and angular resolution of
the observations. A description of the C-PACS technique and the data reduction procedures are presented. C-PACS
was applied to CARMA observations of PP 13S*, which led to a factor of 1.6 increase in the observed peak flux
of the source, a 36% reduction in the noise of the image, and a 52% decrease in the measured size of the source
major axis. The calibrated complex visibilities were fitted with a theoretical disk model to constrain the disk surface
density. The total disk mass from the best-fit model corresponds to 0.06 M_⊙, which is larger than the median mass of a disk around a classical T Tauri star. The disk is optically thick at a wavelength of 1.3 mm for orbital radii less than 48 AU. At larger radii, the inferred surface density of the PP 13S* disk is an order of magnitude lower than that needed to develop a gravitational instability
Personalized web learning by joining OER
We argue that quality issues and didactical concerns of MOOCs may be overcome by relying on small Open Educational Resources, joining them into concise courses by gluing them together along predefined learning pathways with proper semantic annotations. This new approach to adaptive learning does not attempt to model the learner, but rather concentrates on the learning process and established models thereof. Such a new approach does not only require conceptual work and corresponding support tools, but also a new meta data format and an engine which may interpret the semantic annotations as well as measure a learner’s response to these. The EU FP7 project INTUITEL is introduced, which employs these technologies in a novel learning environment
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