The Yellow Wallpaper: A Woman’s journey into an evolved identity

Denne artikkelen tar sikte på å utforske hvordan Gilmans litterære verk The Yellow Wallpaper, eller mer spesifikt hvordan Fortelleren i The Yellow Wallpaper videreformidler et budskap som overskrider Gilmans originale budskap om å advare publikum om restens kur, og også ser ut til å dykke ned i den ideologiske verdenen av å finne sin identitet ved å bryte gjennom de feminine og maskuline sfærene som er satt på plass av samfunnet for å oppnå en utviklet identitet. Denne identiteten, som representerer den nye, moderne kvinnen er fri for sosiale restriksjoner på plass og er i stand til å skape et liv med oppfyllelse i stedet for forpliktelser.This paper will aim to explore how Gilman’s literary work The Yellow Wallpaper, or more specifically how the Narrator in The Yellow Wallpaper relays a message that transcends Gilman’s original message of warning the public of the rest cure, and also seems to delve into the ideological world of finding one’s identity by breaking through the feminine and masculine spheres put in place by society in order to achieve an evolved identity. This identity, which represents the new, modern woman is free of social restrictions in place and is able to create a life of fulfilment instead of obligation

A tablet for healthy ageing: the effect of a tablet computer training intervention on cognitive abilities in older adults

YesObjective: To test the efficacy of a tablet computer training intervention to improve cognitive abilities of older adults. Design: Prospective randomized controlled trial. Setting: Community-based aging intervention study, Edinburgh, UK. Participants: Forty-eight healthy older adults aged 65 to 76 years were recruited at baseline with no or minimal tablet experience;43 completed follow-up testing. Intervention: Twentytwo participants attended a weekly 2-hour class for 10 weeks during which they learned how to use a tablet and various applications on it. Measurements: A battery of cognitive tests from theWAIS-IV measuring the domains ofVerbal Comprehension, Perceptual Processing,Working Memory, and Processing Speed, as well as health, psychological, and well-being measures. Results: A 2× 2 mixed model ANOVA suggested that the tablet intervention group (N = 22) showed greater improvements in Processing Speed (η2 = 0.10) compared with controls (N = 21), but did not differ in Verbal Comprehension, Perceptual Processing, or Working Memory (η2 ranged from −0.03 to 0.04). Conclusions: Engagement in a new mentally challenging activity (tablet training) was associated with improved processing speed.Acquiring skills in later life, including those related to adopting new technologies, may therefore have the potential to reduce or delay cognitive changes associated with ageing.It is important to understand how the development of these skills might further facilitate everyday activities, and also improve older adults’ quality of life.Supported by the Dunhill Medical Trust (R359/0514). Funding from the BBSRC and MR

The potential utility of B cell-directed biologic therapy in autoimmune diseases

Increasing awareness of the importance of aberrant B cell regulation in autoimmunity has driven the clinical development of novel B cell-directed biologic therapies with the potential to treat a range of autoimmune disorders. The first of these drugs—rituximab, a chimeric monoclonal antibody against the B cell-specific surface marker CD20—was recently approved for treating rheumatoid arthritis in patients with an inadequate response to other biologic therapies. The aim of this review is to discuss the potential use of rituximab in the management of other autoimmune disorders. Results from early phase clinical trials indicate that rituximab may provide clinical benefit in systemic lupus erythematosus, Sjögren’s syndrome, vasculitis, and thrombocytopenic purpura. Numerous case reports and several small pilot studies have also been published reporting the use of rituximab in conditions such as myositis, antiphospholipid syndrome, Still’s disease, and multiple sclerosis. In general, the results from these preliminary studies encourage further testing of rituximab therapy in formalized clinical trials. Based on results published to date, it is concluded that rituximab, together with other B cell-directed therapies currently under clinical development, is likely to provide an important new treatment option for a number of these difficult-to-treat autoimmune disorders

The Yellow Wallpaper: A Woman’s journey into an evolved identity

Denne artikkelen tar sikte på å utforske hvordan Gilmans litterære verk The Yellow Wallpaper, eller mer spesifikt hvordan Fortelleren i The Yellow Wallpaper videreformidler et budskap som overskrider Gilmans originale budskap om å advare publikum om restens kur, og også ser ut til å dykke ned i den ideologiske verdenen av å finne sin identitet ved å bryte gjennom de feminine og maskuline sfærene som er satt på plass av samfunnet for å oppnå en utviklet identitet. Denne identiteten, som representerer den nye, moderne kvinnen er fri for sosiale restriksjoner på plass og er i stand til å skape et liv med oppfyllelse i stedet for forpliktelser

Impact of Holocene environmental change on the evolutionary ecology of an Arctic top predator

The Arctic is among the most climatically sensitive environments on Earth, and the disappearance of multiyear sea ice in the Arctic Ocean is predicted within decades. As apex predators, polar bears are sentinel species for addressing the impact of environmental variability on Arctic marine ecosystems. By integrating genomics, isotopic analysis, morphometrics, and ecological modeling, we investigate how Holocene environmental changes affected polar bears around Greenland. We uncover reductions in effective population size coinciding with increases in annual mean sea surface temperature, reduction in sea ice cover, declines in suitable habitat, and shifts in suitable habitat northward. Furthermore, we show that west and east Greenlandic polar bears are morphologically, and ecologically distinct, putatively driven by regional biotic and genetic differences. Together, we provide insights into the vulnerability of polar bears to environmental change and how the Arctic marine ecosystem plays a vital role in shaping the evolutionary and ecological trajectories of its inhabitants.Peer reviewe