Moving forward: fostering the next generation of Earth stewards in the STEM disciplines

Graduate students in the science, technology, engineering, and mathematics (STEM) disciplines struggle with developing research agendas that balance the overall goals of their work with questions of civic concern. The Earth Stewardship Initiative helps to resolve this disparity. Furthermore, connecting STEM research to civic concerns increases the relevance of research and facilitates the development of cross-disciplinary approaches. We describe how STEM graduate students can incorporate Earth Stewardship into their research, identify opportunities for educational institutions to support such research, and discuss the potential benefits of, and barriers to, linking Earth Stewardship to graduate-level studies

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

<p>Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.</p>