1,656 research outputs found
Beta-decay branching ratios of 62Ga
Beta-decay branching ratios of 62Ga have been measured at the IGISOL facility
of the Accelerator Laboratory of the University of Jyvaskyla. 62Ga is one of
the heavier Tz = 0, 0+ -> 0+ beta-emitting nuclides used to determine the
vector coupling constant of the weak interaction and the Vud quark-mixing
matrix element. For part of the experimental studies presented here, the
JYFLTRAP facility has been employed to prepare isotopically pure beams of 62Ga.
The branching ratio obtained, BR= 99.893(24)%, for the super-allowed branch is
in agreement with previous measurements and allows to determine the ft value
and the universal Ft value for the super-allowed beta decay of 62Ga
Chaotic Cascades with Kolmogorov 1941 Scaling
We define a (chaotic) deterministic variant of random multiplicative cascade
models of turbulence. It preserves the hierarchical tree structure, thanks to
the addition of infinitesimal noise. The zero-noise limit can be handled by
Perron-Frobenius theory, just as the zero-diffusivity limit for the fast dynamo
problem. Random multiplicative models do not possess Kolmogorov 1941 (K41)
scaling because of a large-deviations effect. Our numerical studies indicate
that deterministic multiplicative models can be chaotic and still have exact
K41 scaling. A mechanism is suggested for avoiding large deviations, which is
present in maps with a neutrally unstable fixed point.Comment: 14 pages, plain LaTex, 6 figures available upon request as hard copy
(no local report #
Separated Oscillatory Fields for High-Precision Penning Trap Mass Spectrometry
Ramsey's method of separated oscillatory fields is applied to the excitation
of the cyclotron motion of short-lived ions in a Penning trap to improve the
precision of their measured mass. The theoretical description of the extracted
ion-cyclotron-resonance line shape is derived out and its correctness
demonstrated experimentally by measuring the mass of the short-lived Ca
nuclide with an uncertainty of using the ISOLTRAP Penning
trap mass spectrometer at CERN. The mass value of the superallowed beta-emitter
Ca is an important contribution for testing the conserved-vector-current
hypothesis of the electroweak interaction. It is shown that the Ramsey method
applied to mass measurements yields a statistical uncertainty similar to that
obtained by the conventional technique ten times faster.Comment: 5 pages, 4 figures, 0 table
Q-value of the superallowed beta decay of Ga-62
Masses of the radioactive isotopes 62Ga, 62Zn and 62Cu have been measured at
the JYFLTRAP facility with a relative precision of better than 18 ppb. A Q_EC
value of (9181.07 +- 0.54) keV for the superallowed decay of 62Ga is obtained
from the measured cyclotron frequency ratios of 62Ga-62Zn, 62Ga-62Ni and
62Zn-62Ni ions. The resulting Ft-value supports the validity of the conserved
vector current hypothesis (CVC). The mass excess values measured were (-51986.5
+-1.0) keV for 62Ga, (-61167.9 +- 0.9) keV for 62Zn and (-62787.2 +- 0.9) keV
for 62Cu.Comment: 12 pages, 3 figures, 2 tables, submitted to Phys. Lett. B. v2: added
acknowledgement
Multiple-Point and Multiple-Time Correlations Functions in a Hard-Sphere Fluid
A recent mode coupling theory of higher-order correlation functions is tested
on a simple hard-sphere fluid system at intermediate densities. Multi-point and
multi-time correlation functions of the densities of conserved variables are
calculated in the hydrodynamic limit and compared to results obtained from
event-based molecular dynamics simulations. It is demonstrated that the mode
coupling theory results are in excellent agreement with the simulation results
provided that dissipative couplings are included in the vertices appearing in
the theory. In contrast, simplified mode coupling theories in which the
densities obey Gaussian statistics neglect important contributions to both the
multi-point and multi-time correlation functions on all time scales.Comment: Second one in a sequence of two (in the first, the formalism was
developed). 12 pages REVTeX. 5 figures (eps). Submitted to Phys.Rev.
Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence
The response rates upon neoadjuvant immune checkpoint blockade (ICB) in stage III melanoma are higher as compared with stage IV disease. Given that successful ICB depends on systemic immune response, we hypothesized that systemic immune suppression might be a mechanism responsible for lower response rates in late-stage disease, and also potentially with disease recurrence in early-stage disease. Plasma and serum samples of cohorts of patients with melanoma were analyzed for circulating proteins using mass spectrometry proteomic profiling and Olink proteomic assay. A cohort of paired samples of patients with stage III that progressed to stage IV disease (n = 64) was used to identify markers associated with higher tumor burden. Baseline patient samples from the OpACIN-neo study (n = 83) and PRADO study (n = 49; NCT02977052) were used as two independent cohorts to analyze whether the potential identified markers are also associated with disease recurrence after neoadjuvant ICB therapy. When comparing baseline proteins overlapping between patients with progressive disease and patients with recurrent disease, we found leucine-rich alpha-2-glycoprotein 1 (LRG1) to be associated with worse prognosis. Especially nonresponder patients to neoadjuvant ICB (OpACIN-neo) with high LRG1 expression had a poor outcome with an estimated 36-month event-free survival of 14% as compared with 83% for nonresponders with a low LRG1 expression (P = 0.014). This finding was validated in an independent cohort (P = 0.0021). LRG1 can be used as a biomarker to identify patients with high risk for disease progression and recurrence, and might be a target to be combined with neoadjuvant ICB.
Significance:
LRG1 could serve as a potential target and as a biomarker to identify patients with high risk for disease recurrence, and consequently benefit from additional therapies and intensive follow-up
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