Prolonged viral replication and longitudinal viral dynamic differences among respiratory syncytial virus infected infants

© 2017 2017 International Pediatric Research Foundation, Inc. BackgroundLongitudinal respiratory syncytial virus (RSV) dynamics have not been well studied despite the existence of factors favoring prolonged RSV replication including high mutation rates allowing rapid evolution and potential escape from immune control. We therefore measured viral load in previously RSV-naive infants over prolonged time spans.MethodsDuring 2014-2015, quantitative nasal aspirates were collected from 51 RSV-PCR+ infants. Multiple parallel assessments of viral loads were quantified at each collected time point using a well-validated real-time quantitative reverse transcriptase polymerase chain reaction assay. After observing viral load rebound phenomenon in some infants, the viral dynamics of 27 infants with sufficient longitudinal viral load data points were analyzed using the pre-defined criteria for viral rebound. Additional analyses were performed comparing age with viral rebound, viral clearance rates, and viral load area-under-the-curve (AUC VL).ResultsThe 51 infants (303 nasal aspirate samples; mean of 5.9 per patient) exhibited slower than expected viral clearance. Lower age trended toward slower viral clearance and greater AUC VL. Six infants had detectable viral loads ≥1 month after symptom onset. Ten of twenty-seven evaluable subjects exhibited viral rebound and this rebound was age-dependent (P=0.0259). All but one rebounder were rebound; likely representing viral mutational immune escape

Salud de los trabajadores

Actividad física y su relación con los factores de riesgo cardiovascular de carteros chilenosAnálisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam QuellónAusentismo laboral por enfermedades oftalmológicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constitución, Región del MauleCalidad de vida en profesionales de la salud pública chilenaCaracterización del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentración de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de enseñanza media de SantiagoDisfunción auditiva inducida por exposición a xilenoErgonomía aplicada al estudio del síndrome de dolor lumbar en el trabajoEstimación de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposición a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y daños de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepción de cambios en la práctica médica y estrategias de afrontamientoPercepción de la calidad de vida en la Universidad del BiobíoPesos máximos aceptables para tareas de levantamiento manual de carga en población laboral femeninaRiesgo coronario en trabajadores mineros según la función de Framingham adaptada para la población chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu

Estudio de factibilidad para el diseño, venta y distribucion de Biodigestores en el Canton Salitre

El presente plan de negocios tiene como propósito la creación de una compañía de sociedad anónima cuyo nombre será Green Gas S.A., ubicada en el cantón salitre de la provincia del guayas, que ofrezca a los ganaderos del cantón, a través de su producto - Biodigestor, la oportunidad de utilizar la materia orgánica de su ganado transformándola en abono rico en minerales para sus plantaciones y la oportunidad de producir su propio Combustible-Biogás,para la cocción de alimentos o como alimentador de generadores de energía eléctrica.GuayaquilMagíster en Administración de Empresa

The WISE 2000 and 2001 Field Experiments in Support of the SMOS Mission:Sea Surface L-Band Brightness Temperature Observations and Their Application to Sea Surface Salinity Retrieval.

Soil Moisture and Ocean Salinity (SMOS) is an Earth Explorer Opportunity Mission from the European Space Agency with a launch date in 2007. Its goal is to produce global maps of soil moisture and ocean salinity variables for climatic studies using a new dual-polarization L-band (1400-1427 MHz) radiometer Microwave Imaging Radiometer by Aperture Synthesis (MIRAS). SMOS will have multiangular observation capability and can be optionally operated in full-polarimetric mode. At this frequency the sensitivity of the brightness temperature (T/sub B/) to the sea surface salinity (SSS) is low: 0.5 K/psu for a sea surface temperature (SST) of 20/spl deg/C, decreasing to 0.25 K/psu for a SST of 0/spl deg/C. Since other variables than SSS influence the T/sub B/ signal (sea surface temperature, surface roughness and foam), the accuracy of the SSS measurement will degrade unless these effects are properly accounted for. The main objective of the ESA-sponsored Wind and Salinity Experiment (WISE) field experiments has been the improvement of our understanding of the sea state effects on T/sub B/ at different incidence angles and polarizations. This understanding will help to develop and improve sea surface emissivity models to be used in the SMOS SSS retrieval algorithms. This paper summarizes the main results of the WISE field experiments on sea surface emissivity at L-band and its application to a performance study of multiangular sea surface salinity retrieval algorithms. The processing of the data reveals a sensitivity of T/sub B/ to wind speed extrapolated at nadir of /spl sim/0.23-0.25 K/(m/s), increasing at horizontal (H) polarization up to /spl sim/0.5 K/(m/s), and decreasing at vertical (V) polarization down to /spl sim/-0.2 K/(m/s) at 65/spl deg/ incidence angle. The sensitivity of T/sub B/ to significant wave height extrapolated to nadir is /spl sim/1 K/m, increasing at H-polarization up to /spl sim/1.5 K/m, and decreasing at V-polarization down to -0.5 K/m at 65/spl deg/. A modulation of the instantaneous brightness temperature T/sub B/(t) is found to be correlated with the measured sea surface slope spectra. Peaks in T/sub B/(t) are due to foam, which has allowed estimates of the foam brightness temperature and, taking into account the fractional foam coverage, the foam impact on the sea surface brightness temperature. It is suspected that a small azimuthal modulation /spl sim/0.2-0.3 K exists for low to moderate wind speeds. However, much larger values (4-5 K peak-to-peak) were registered during a strong storm, which could be due to increased foam. These sensitivities are satisfactorily compared to numerical models, and multiangular T/sub B/ data have been successfully used to retrieve sea surface salinity

The EFSUMB guidelines and recommendations for musculoskeletal ultrasound – Part I: Extraarticular pathologies

The first part of the guidelines and recommendations for musculoskeletal ultrasound, produced under the auspices of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB), provides information about the use of musculoskeletal ultrasound for assessing extraarticular structures (muscles, tendons, entheses, ligaments, bones, bursae, fasciae, nerves, skin, subcutaneous tissues, and nails) and their pathologies. Clinical applications, practical points, limitations, and artifacts are described and discussed for every structure. After an extensive literature review, the recommendations have been developed according to the Oxford Centre for Evidence-based Medicine and GRADE criteria and the consensus level was established through a Delphi process. The document is intended to guide clinical users in their daily practice

The EFSUMB Guidelines and Recommendations for Musculoskeletal Ultrasound – Part II: Joint Pathologies, Pediatric Applications, and Guided Procedures.

The second part of the Guidelines and Recommendations for Musculoskeletal Ultrasound (MSUS), produced under the auspices of EFSUMB, following the same methodology as for Part 1, provides information and recommendations on the use of this imaging modality for joint pathology, pediatric applications, and musculoskeletal ultrasound-guided procedures. Clinical application, practical points, limitations, and artifacts are described and discussed for every joint or procedure. The document is intended to guide clinical users in their daily practice

Salud de los trabajadores

Actividad física y su relación con los factores de riesgo cardiovascular de carteros chilenosAnálisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam QuellónAusentismo laboral por enfermedades oftalmológicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constitución, Región del MauleCalidad de vida en profesionales de la salud pública chilenaCaracterización del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentración de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de enseñanza media de SantiagoDisfunción auditiva inducida por exposición a xilenoErgonomía aplicada al estudio del síndrome de dolor lumbar en el trabajoEstimación de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposición a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y daños de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepción de cambios en la práctica médica y estrategias de afrontamientoPercepción de la calidad de vida en la Universidad del BiobíoPesos máximos aceptables para tareas de levantamiento manual de carga en población laboral femeninaRiesgo coronario en trabajadores mineros según la función de Framingham adaptada para la población chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu