780 research outputs found

    Public Issues Education: Exploring Extension\u27s Role

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    Extension educators in all program areas have become increasingly involved with controversial public issues in recent years. Given the nature of these issues and the expectations placed on agents and specialists by the public and by university officials, Extension\u27s continued involvement seems inevitable. This article provides a conceptual framework that identifies potential roles for public officials, the general public, and Extension professionals in dealing with public issues. The article concludes with some specific advice for Extension educators involved with programming that addresses controversial topics

    Candida famata central nervous system infection

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    Application of Beamforming Methods to Full-Scale Military Jet Noise

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    Over the past decade, beamforming in aeroacoustics applications have undergone significant advances. Cross beamforming methods improve upon traditional beamforming in that they relax the assumption of multiple-source incoherence. This paper compares the abilities of three cross beamforming methods to reproduce source and field characteristics for an extended, partially correlated source that mimics supersonic jet noise radiation. Standard cross beamforming and two related methods that involve regularization—the hybrid method and improved generalized inverse beamforming—are applied to a numerically generated dataset along a near-field line. Estimated levels and coherence lengths are compared with benchmarks at the source as well as near and far-field locations. All three methods are successful in reproducing the field and source properties in high-amplitude regions. Although regularization generally helps to improve both source and field reconstructions, results are sensitive to regularization parameters, particularly for the generalized inverse method. The successful application of the three methods demonstrate the utility of cross-beamforming in formulating equivalent source models for accurate field prediction of complex sources, including jet noise

    SOST Inhibits Prostate Cancer Invasion.

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    Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored. Here we show that elevated Wnt signaling derived from Sost deficient osteoblasts promotes PC invasion, while rhSOST has an inhibitory effect. In contrast, rhDKK1 promotes PC elongation and filopodia formation, morphological changes characteristic of an invasive phenotype. Furthermore, rhDKK1 was found to activate canonical Wnt signaling in PC3 cells, suggesting that SOST and DKK1 have opposing roles on Wnt signaling in this context. Gene expression analysis of PC3 cells co-cultured with OBs exhibiting varying amounts of Wnt signaling identified CRIM1 as one of the transcripts upregulated under highly invasive conditions. We found CRIM1 overexpression to also promote cell-invasion. These findings suggest that bone-derived Wnt signaling may enhance PC tropism by promoting CRIM1 expression and facilitating cancer cell invasion and adhesion to bone. We concluded that SOST and DKK1 have opposing effects on PC3 cell invasion and that bone-derived Wnt signaling positively contributes to the invasive phenotypes of PC3 cells by activating CRIM1 expression and facilitating PC-OB physical interaction. As such, we investigated the effects of high concentrations of SOST in vivo. We found that PC3-cells overexpressing SOST injected via the tail vein in NSG mice did not readily metastasize, and those injected intrafemorally had significantly reduced osteolysis, suggesting that targeting the molecular bone environment may influence bone metastatic prognosis in clinical settings

    Super-Poincare' algebras, space-times and supergravities (I)

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    A new formulation of theories of supergravity as theories satisfying a generalized Principle of General Covariance is given. It is a generalization of the superspace formulation of simple 4D-supergravity of Wess and Zumino and it is designed to obtain geometric descriptions for the supergravities that correspond to the super Poincare' algebras of Alekseevsky and Cortes' classification.Comment: 29 pages, v2: minor improvements at the end of Section 5.

    Rural Sewage Disposal for Individual Homes

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    This publication provides recommendations for rural wastewater disposal, including sewage flows, the house sewer, septic tanks, tile disposal systems, and above-ground systems

    RM methods for airline fare family structures

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    Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2013.This electronic version was submitted and approved by the author's academic department as part of an electronic thesis pilot project. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from department-submitted PDF version of thesisIncludes bibliographical references (p. 119-121).The rapid growth of low cost carriers forced many legacy airlines to simplify their fare structures and develop new pricing strategies to remain competitive. The strategy of branded fares, or "fare families", is an increasingly popular approach for airlines to differentiate their products and services from other competitors. This thesis provides a comprehensive overview of revenue management (RM) forecasting and optimization methods developed specifically for fare family structures. These methods, collectively termed Q-Forecasting for Fare Families (QFF), provide airlines with the capability to manage branded fares from a RM perspective. The QFF methods are all constructed based on the assumed fare family passenger choice model, which accounts for both willingness-to-pay estimates as well as family preference. Each formulation makes underlying assumptions regarding passenger sell-up and buy-across. The Passenger Origin Destination Simulator is used to test and compare the performance of each QFF formulation in a dual airline competitive environment, both with leg-based RM controls as well as network RM controls. The results from the simulations indicate that substantial gains in both revenue and yield over traditional RM methods can be achieved with appropriate RM in a fare family structure. Specifically, while Hybrid Forecasting (with leg RM controls) generates a 4.0% increase in revenue over Standard Forecasting, QFF is shown to increase revenues by more than 12.5%. The benefits of QFF are greater with network RM controls, with potential revenue increases of nearly 14.0% (over Standard Forecasting). The positive results obtained with each QFF formulation are dependent upon an appropriate estimate for passenger sell-up and family preference. Consequently, this research also illustrates the importance of the estimate for passenger willingness-to- pay and its relationship to forecasting and optimization in airline RM.by Vincent B. Surges.S.M

    Graphical models for visual object recognition and tracking

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    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2006.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 277-301).We develop statistical methods which allow effective visual detection, categorization, and tracking of objects in complex scenes. Such computer vision systems must be robust to wide variations in object appearance, the often small size of training databases, and ambiguities induced by articulated or partially occluded objects. Graphical models provide a powerful framework for encoding the statistical structure of visual scenes, and developing corresponding learning and inference algorithms. In this thesis, we describe several models which integrate graphical representations with nonparametric statistical methods. This approach leads to inference algorithms which tractably recover high-dimensional, continuous object pose variations, and learning procedures which transfer knowledge among related recognition tasks. Motivated by visual tracking problems, we first develop a nonparametric extension of the belief propagation (BP) algorithm. Using Monte Carlo methods, we provide general procedures for recursively updating particle-based approximations of continuous sufficient statistics. Efficient multiscale sampling methods then allow this nonparametric BP algorithm to be flexibly adapted to many different applications.(cont.) As a particular example, we consider a graphical model describing the hand's three-dimensional (3D) structure, kinematics, and dynamics. This graph encodes global hand pose via the 3D position and orientation of several rigid components, and thus exposes local structure in a high-dimensional articulated model. Applying nonparametric BP, we recover a hand tracking algorithm which is robust to outliers and local visual ambiguities. Via a set of latent occupancy masks, we also extend our approach to consistently infer occlusion events in a distributed fashion. In the second half of this thesis, we develop methods for learning hierarchical models of objects, the parts composing them, and the scenes surrounding them. Our approach couples topic models originally developed for text analysis with spatial transformations, and thus consistently accounts for geometric constraints. By building integrated scene models, we may discover contextual relationships, and better exploit partially labeled training images. We first consider images of isolated objects, and show that sharing parts among object categories improves accuracy when learning from few examples.(cont.) Turning to multiple object scenes, we propose nonparametric models which use Dirichlet processes to automatically learn the number of parts underlying each object category, and objects composing each scene. Adapting these transformed Dirichlet processes to images taken with a binocular stereo camera, we learn integrated, 3D models of object geometry and appearance. This leads to a Monte Carlo algorithm which automatically infers 3D scene structure from the predictable geometry of known object categories.by Erik B. Sudderth.Ph.D

    O\u27Brien, M. (Torno - 5 acres tract No. 25, Section 58; Ware - Tract No. 25 in Section 58, 5 acres), 1944-1951

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    2.4 Real estate, Box 119, Folder 58https://scholarworks.utrgv.edu/johnshary/1107/thumbnail.jp

    Dual optimization method of radiofrequency and quasistatic field simulations for reduction of eddy currents generated on 7T radiofrequency coil shielding.

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    PURPOSE: To optimize the design of radiofrequency (RF) shielding of transmit coils at 7T and reduce eddy currents generated on the RF shielding when imaging with rapid gradient waveforms. METHODS: One set of a four-element, 2 Ă— 2 Tic-Tac-Toe head coil structure was selected and constructed to study eddy currents on the RF coil shielding. The generated eddy currents were quantitatively studied in the time and frequency domains. The RF characteristics were studied using the finite difference time domain method. Five different kinds of RF shielding were tested on a 7T MRI scanner with phantoms and in vivo human subjects. RESULTS: The eddy current simulation method was verified by the measurement results. Eddy currents induced by solid/intact and simple-structured slotted RF shielding significantly distorted the gradient fields. Echo-planar images, B1+ maps, and S matrix measurements verified that the proposed slot pattern suppressed the eddy currents while maintaining the RF characteristics of the transmit coil. CONCLUSION: The presented dual-optimization method could be used to design RF shielding and reduce the gradient field-induced eddy currents while maintaining the RF characteristics of the transmit coil
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