14 research outputs found

    Motivaciones para continuar con el embarazo en gestantes adolescentes atendidas en un hospital nivel II de Essalud. Chiclayo, 2017

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    El embarazo en adolescentes es un suceso difícil de aceptar en la mayoría de los casos, ya que cuando la pareja conoce su situación se constituye como un evento inesperado, sorpresivo, no planeado y frecuentemente no deseado. Objetivo: Describir, analizar y discutir las motivaciones para continuar con el embarazo en gestantes adolescentes atendidas en un Hospital nivel II de EsSalud. Chiclayo 2017. Métodos: Estudio cualitativo, abordaje estudio de caso, cuya muestra fue 17 gestantes adolescentes; el muestreo fue no probabilístico, por conveniencia y el tamaño se determinó por saturación y redundancia; los datos se recolectaron mediante una guía de entrevista semiestructurada, validada por juicio de expertos y por piloto; el análisis fue mediante el análisis de contenido. Resultados: I.-Motivaciones trascendentes ante la ocurrencia del embarazo: con sus subcategorías: Reconocimiento del hijo como don divino con expresión de felicidad; Aceptación del embarazo por las familias y la pareja y sentir la vida engendrada en crecimiento. II.- Enfrentando Obstáculos que impiden continuar con el embarazo, con sus subcategorías: Rechazo del aborto, imperativo por la vida; De la frustración de planes a la resignación por el futuro del bebé e ilusión en continuar estudios con apoyo de la familia: autorrealización. Conclusión: Las adolescentes experimentan su embarazo como un acontecimiento inesperado, con sentimientos positivos en la gran mayoría: alegría y felicidad, versus sentimientos de displacer: angustia, temor, miedo y tristeza, acompañados al inicio de presiones externas conducentes al aborto; pero, que finalmente prima las motivaciones trascendentes que las llevan a continuar con el embarazo, como el aceptar el embarazo como un don divino, el sentir la vida engendrada y recibir el apoyo de la familia y pareja.Tesi

    The Library as Publisher? Publishing at Portland State University and Oregon State University

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    The traditional role of libraries as aggregators, curators and disseminators of resources has been profoundly challenged by the notion of libraries as publishers of content. The traditional publishing model is based on ownership, commerce, paid exchanges, and scholarship as a commodity. Libraries are based on a service model of sharing resources & free exchange. Academic libraries are therefore uniquely positioned to provide publishing solutions which can reduce student costs and provide faculty and students an alternative to traditional publishing. Both Portland State University (PSU) Library and Oregon State University Libraries and Press (OSULP) are providing a variety of publishing solutions to their respective campuses. Attendees will learn about an array of library publishing projects, including PSU’s reTHINK PDX Open Textbook project (part of the Provost’s Challenge), OSULP’s Open Textbook Initiative, publication of conference proceedings and journals (including student-run journals), a student iBook Author project, and several other unique library-campus collaborations. Challenges and opportunities for Library publishing will be discussed, and existing Library publishing models will be examined

    Creating New Partnerships: Strategies for Growing Your Repository

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    Academic institutions, as well as private corporations, have taken on the responsibility of building institutional repositories in order to collect, manage, archive and provide access to the intellectual work taking place on their respective campuses. Over the years, building or procuring a repository has become fairly straightforward. Filling it hasn't. Convincing faculty and academic units to contribute their research and scholarship is still a struggle for most repository owners and requires equal parts determination, imagination and perspiration. Join four repository managers from OSU, PSU, WSU and Kaiser Permanente as they share their experiences attempting to fill the repository. <div><br></div><div>This presentation was given February 8 at Online NW 2013 in Corvallis, OR. </div

    Influence of operator experience on performance of ultrasound-guided percutaneous liver biopsy.

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    The purpose was to evaluate the influence of radiologist's experience on the diagnostic yield and complications of a percutaneous liver biopsy (PLB) method. Six hundred patients underwent an ultrasound-guided PLB by an inexperienced operator in 25.2% of cases (experience of less than 15 percutaneous liver biopsies performed alone--group I) or by an experienced operator (experience of more than 150 percutaneous liver biopsies--group II). The two groups were well-matched with respect to sex, age, percentage with viral hepatitis without histological cirrhosis, number of needle passes, history of liver biopsy and pain before the biopsy. A histological diagnosis was available in 97.3% of cases without any significant difference between the two groups ( P=0.25). However, group II samples were significantly longer and contained more portal tracts ( P=0.01). Pain was mild immediately and 6 h after the biopsy, without significant difference between both groups. Eight vasovagal reactions (five in group II) and one arteriobiliary fistula (in group II) occurred. With the method of PLB used for this study, operator's experience did not influence either the final histological diagnosis or the degree of pain suffered

    Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast

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    Differentiated mammary epithelium shows apicobasal polarity, and loss of tissue organization is an early hallmark of breast carcinogenesis. In BRCA1 mutation carriers, accumulation of stem and progenitor cells in normal breast tissue and increased risk of developing tumors of basal-like type suggest that BRCA1 regulates stem/progenitor cell proliferation and differentiation. However, the function of BRCA1 in this process and its link to carcinogenesis remain unknown. Here we depict a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer. Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio (wHR) = 1.09 (95% CI 1.02–1.16), ptrend = 0.017; and n = 3,965, wHR = 1.04 (95% CI 0.94–1.16), ptrend = 0.43; respectively. Subsequently, studies of MCF10A apicobasal polarization revealed a central role for BRCA1 and RHAMM, together with AURKA and TPX2, in essential reorganization of microtubules. Mechanistically, reorganization is facilitated by BRCA1 and impaired by AURKA, which is regulated by negative feedback involving RHAMM and TPX2. Taken together, our data provide fundamental insight into apicobasal polarization through BRCA1 function, which may explain the expanded cell subsets and characteristic tumor type accompanying BRCA1 mutation, while also linking this process to sporadic breast cancer through perturbation of HMMR/RHAMM.This work was funded by the Spanish Ministries of Health, and Science ane Innovation (CB07/02/2005; FIS 08/1120, 08/1359, 08/1635, and 09/02483; RTICCC RD06/0020/1060 and RD06/0020/0028; Transversal Action Against Cancer; the Spanish Biomedical Research Centre Networks for Epidemiology and Public Health, and Rare Diseases; and the ‘‘Ramón y Cajal’’ Young Investigator Program), the Spanish National Society of Medical Oncology (2010), the SpanishAssociation Against Cancer (AECC 2010), the AGAUR Catalan Government Agency (2009SGR1489 and 2009SGR293; and the Beatriu Pinós Postdoctoral Program), the Ramón Areces Foundation (XV), the ‘‘Roses Contra el Caàncer’’ Foundation, the Michael Cuccione Foundation for Childhood Cancer Research, Cancer Research–UK (C490/A10119, C1287/A8874, C1287/A10118, C5047/A8385, and C8197/A10123), the National Institute for Health Research (UK), the Association for International Cancer Research (AICR-07-0454), the Ligue National Contre le Cancer (France), the Association ‘‘Le cancer du sein, parlons en!’’, the Dutch Cancer Society (NKI 1998–1854, 2004–3088, and 2007–3756), the Fondazione Italiana per la Ricerca sul Cancro (‘‘Hereditary Tumors’’), the Associazione Italiana per la Ricerca sul Cancro (4017), the Italian Ministero della Salute (RFPS-2006-3-340203 and ‘‘Progetto Tumori Femminili’’), the Italian Ministero dell’Universita’ e Ricerca(RBLAO3-BETH), the Fondazione IRCCS Istituto Nazionale Tumori (INT ‘‘561000’’), the Fondazione Cassa di Risparmio di Pisa (Istituto Toscano Tumori), the National Breast Cancer Foundation (Australia), the Australian National Health and Medical Research Council (145684, 288704, and 454508), the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania, and South Australia, the Cancer Foundation of Western Australia, the German Cancer Aid (107054), the Center for Molecular Medicine Cologne (TV93), the National Cancer Institute (USA; CA128978 and CA122340), National Institutes of Health (RFA-CA-06-503, BCFR U01 CA69398, CA69417, CA69446, CA69467, CA69631, and CA69638), the Research Triangle Institute Informatics Support Center (RFP N02PC45022-4/n6), the Specialized Program of Research Excellence (SPORE P50 CA83638 and CA113916), the Department of Defense Breast Cancer Research Program (05/0612), the Eileen Stein Jacoby Fund, the Breast Cancer Research Foundation, the Marianne and Robert MacDonald Foundation, the Komen Foundation, the Helsinki University Central Hospital Research Fund, the Academy of Finland (110663), the Finnish Cancer Society, the Sigrid Juselius Foundation, and the EU FP7 (223175,HEALTH-F2-2009-223175). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip
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