The effects of police patrolling on trunk road traffic

Police patrols are normally allocated to traffic duties with the objective of influencing driver behaviour, and thereby reducing road accidents. When scheduling police traffic patrol resources between routes it is therefore important to know what effect they might be expected to produce, on both driver behaviour and accidents. Similarly, knowledge of these effects are important in deciding the extent of the nation's resources to be allocated to this purpose. This thesis explores the effects of changes in the levels and tactics of police patrolling on driver behaviour, and on the accident rate. Previous published work is analysed and discussed, together with new experiments conducted in the Durham Constabulary Area. In carrying out these experiments, weaknesses in police and traffic engineering procedures became apparent. These too are discussed in detail. No statistically significant changes were observed, in the accident rate, or in any of the measures of driver behaviour investigated, in the presence of various levels and tactics of police patrolling. This was despite quite narrow confidence limits on most of the measures of driver behaviour

Low Temperature Mechanical Testing of Carbon-Fiber/Epoxy-Resin Composite Materials

The use of cryogenic fuels (liquid oxygen and liquid hydrogen) in current space transportation vehicles, in combination with the proposed use of composite materials in such applications, requires an understanding of how such materials behave at cryogenic temperatures. In this investigation, tensile intralaminar shear tests were performed at room, dry ice, and liquid nitrogen temperatures to evaluate the effect of temperature on the mechanical response of the IM7/8551-7 carbon-fiber/epoxy-resin system. Quasi-isotropic lay-ups were also tested to represent a more realistic lay-up. It was found that the matrix became both increasingly resistant to microcracking and stiffer with decreasing temperature. A marginal increase in matrix shear strength with decreasing temperature was also observed. Temperature did not appear to affect the integrity of the fiber-matrix bond

Equivariant cohomology and analytic descriptions of ring isomorphisms

In this paper we consider a class of connected closed $G$-manifolds with a non-empty finite fixed point set, each $M$ of which is totally non-homologous to zero in $M_G$ (or $G$-equivariantly formal), where $G={\Bbb Z}_2$. With the help of the equivariant index, we give an explicit description of the equivariant cohomology of such a $G$-manifold in terms of algebra, so that we can obtain analytic descriptions of ring isomorphisms among equivariant cohomology rings of such $G$-manifolds, and a necessary and sufficient condition that the equivariant cohomology rings of such two $G$-manifolds are isomorphic. This also leads us to analyze how many there are equivariant cohomology rings up to isomorphism for such $G$-manifolds in 2- and 3-dimensional cases.Comment: 20 pages, updated version with two references adde

Recommendations for future research in relation to pediatric pulmonary embolism: communication from the SSC of the ISTH

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142464/1/jth13902_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142464/2/jth13902.pd

R2 - A Natural Language Question-Answering System

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryJoint Services Electronics Program / DAAB-07-67-C-0199Office of Education / C-1-7-071213-455

Is every toric variety an M-variety?

A complex algebraic variety X defined over the real numbers is called an M-variety if the sum of its Betti numbers (for homology with closed supports and coefficients in Z/2) coincides with the corresponding sum for the real part of X. It has been known for a long time that any nonsingular complete toric variety is an M-variety. In this paper we consider whether this remains true for toric varieties that are singular or not complete, and we give a positive answer when the dimension of X is less than or equal to 3.Comment: 13 page

Apixaban overdose in children: case report and proposed management. A brief communication from the Pediatric and Neonatal Thrombosis and Hemostasis SSC of ISTH

\ua9 2024 The Authors. Background: Direct oral anticoagulants are commonly prescribed for adults and increasingly also for children requiring anticoagulation therapy. While household medications should not be accessible to children, accidental, and intentional overdoses occur. Key Clinical Question: How should apixaban overdose in children be managed?. Clinical Approach: We present a case of an accidental overdose with the factor Xa antagonist apixaban in a young child and propose an approach to the management of cases of apixaban overdose in children. Conclusion: Given the increasing use of direct oral anticoagulants, it is important to have an approach to the management of overdose of these medications

Loneliness and the Emotional Experience of Absence

In this paper, we develop an analysis of the structure and content of loneliness. We argue that this is an emotion of absence-an affective state in which certain social goods are regarded as out of reach for the subject of experience. By surveying the range of social goods that appear to be missing from the lonely person's perspective, we see what it is that can make this emotional condition so subjectively awful for those who undergo it, including the profound sense of being unable to realise oneself, in collaboration with others

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects

Inherited thrombocytopenias are a heterogeneous group of disorders characterised by abnormally low platelet counts which can be associated with abnormal bleeding. Next generation sequencing has previously been employed in these disorders for the confirmation of suspected genetic abnormalities, and more recently in the discovery of novel disease causing genes. However its full potential has not previously been utilised. Over the past 6 years we have sequenced the exomes from 55 patients, including 37 index cases and 18 additional family members, all of whom were recruited to the UK Genotyping and Phenotyping of Platelets study. All patients had inherited or sustained thrombocytopenia of unknown aetiology with platelet counts varying from 11-186x109 /L. Of the 51 patients phenotypically tested, 37 (73%), had an additional secondary qualitative platelet defect. Using whole exome sequencing analysis we have identified “pathogenic” or “likely pathogenic” variants in 46% (17/37) of our index patients with thrombocytopenia. In addition, we report variants of uncertain significance in 12 index cases which include novel candidate genetic variants in previously unreported genes in four index cases. These results demonstrate that whole exome sequencing is an efficient method for elucidating potential pathogenic genetic variants in inherited thrombocytopenia. Whole exome sequencing also has the added benefit of discovering potentially pathogenic genetic variants for further study in novel genes not previously implicated in inherited thrombocytopenia