Asteroseismology of the Kepler V777 Herculis variable white dwarf with fully evolutionary models

Context. DBV stars are pulsating white dwarfs with atmospheres rich in He. Asteroseismology of DBV stars can provide valuable clues about the origin, structure and evolution of hydrogen-deficient white dwarfs, and may allow to study neutrino and axion physics. Recently, a new DBV star, KIC 8626021, has been discovered in the field of the Kepler spacecraft. It is expected that further monitoring of this star in the next years will enable astronomers to determine its detailed asteroseismic profile. Aims. We perform an asteroseismological analysis of KIC 8626021 on the basis of fully evolutionary DB white-dwarf models. Methods. We employ a complete set of evolutionary DB white-dwarf structures covering a wide range of effective temperatures and stellar masses. They have been obtained on the basis of a complete treatment of the evolutionary history of progenitors stars. We compute g-mode adiabatic pulsation periods for this set of models and compare them with the pulsation properties exhibited by KIC 8626021. Results. On the basis of the mean period spacing of the star, we found that the stellar mass should be substantially larger than spectroscopy indicates. From period-to-period fits we found an asteroseismological model characterized by an effective temperature much higher than the spectroscopic estimate. Conclusions. In agreement with a recent asteroseismological analysis of this star by other authors, we conclude that KIC 8626021 is located near the blue edge of the DBV instability strip, contrarily to spectroscopic predictions. We also conclude that the mass of KIC 8626021 should be substantially larger than thought.Facultad de Ciencias Astronómicas y Geofísica

New chemical profiles for the asteroseismology of ZZ CETI stars

We compute new chemical profiles for the core and envelope of white dwarfs appropriate for pulsational studies of ZZ Ceti stars. These profiles are extracted from the complete evolution of progenitor stars, evolved through the main sequence and the thermally pulsing asymptotic giant branch (AGB) stages, and from time-dependent element diffusion during white dwarf evolution. We discuss the importance of the initial-final mass relationship for the white dwarf carbon-oxygen composition. In particular, we find that the central oxygen abundance may be underestimated by about 15% if the white dwarf mass is assumed to be the hydrogen-free core mass before the first thermal pulse. We also discuss the importance for the chemical profiles expected in the outermost layers of ZZ Ceti stars of the computation of the thermally pulsing AGB phase and of the phase in which element diffusion is relevant. We find a strong dependence of the outer layer chemical stratification on the stellar mass. In particular, in the less massive models, the double-layered structure in the helium layer built up during the thermally pulsing AGB phase is not removed by diffusion by the time the ZZ Ceti stage is reached. Finally, we perform adiabatic pulsation calculations and discuss the implications of our new chemical profiles for the pulsational properties of ZZ Ceti stars. We find that the whole g-mode period spectrum and the mode-trapping properties of these pulsating white dwarfs as derived from our new chemical profiles are substantially different from those based on chemical profiles widely used in existing asteroseismological studies. Thus, we expect the asteroseismological models derived from our chemical profiles to be significantly different from those found thus far.Facultad de Ciencias Astronómicas y Geofísica

Asteroseismology of the Kepler V777 Herculis variable white dwarf with fully evolutionary models

Context. DBV stars are pulsating white dwarfs with atmospheres rich in He. Asteroseismology of DBV stars can provide valuable clues about the origin, structure and evolution of hydrogen-deficient white dwarfs, and may allow to study neutrino and axion physics. Recently, a new DBV star, KIC 8626021, has been discovered in the field of the Kepler spacecraft. It is expected that further monitoring of this star in the next years will enable astronomers to determine its detailed asteroseismic profile. Aims. We perform an asteroseismological analysis of KIC 8626021 on the basis of fully evolutionary DB white-dwarf models. Methods. We employ a complete set of evolutionary DB white-dwarf structures covering a wide range of effective temperatures and stellar masses. They have been obtained on the basis of a complete treatment of the evolutionary history of progenitors stars. We compute g-mode adiabatic pulsation periods for this set of models and compare them with the pulsation properties exhibited by KIC 8626021. Results. On the basis of the mean period spacing of the star, we found that the stellar mass should be substantially larger than spectroscopy indicates. From period-to-period fits we found an asteroseismological model characterized by an effective temperature much higher than the spectroscopic estimate. Conclusions. In agreement with a recent asteroseismological analysis of this star by other authors, we conclude that KIC 8626021 is located near the blue edge of the DBV instability strip, contrarily to spectroscopic predictions. We also conclude that the mass of KIC 8626021 should be substantially larger than thought.Facultad de Ciencias Astronómicas y Geofísica

New chemical profiles for the asteroseismology of ZZ CETI stars

We compute new chemical profiles for the core and envelope of white dwarfs appropriate for pulsational studies of ZZ Ceti stars. These profiles are extracted from the complete evolution of progenitor stars, evolved through the main sequence and the thermally pulsing asymptotic giant branch (AGB) stages, and from time-dependent element diffusion during white dwarf evolution. We discuss the importance of the initial-final mass relationship for the white dwarf carbon-oxygen composition. In particular, we find that the central oxygen abundance may be underestimated by about 15% if the white dwarf mass is assumed to be the hydrogen-free core mass before the first thermal pulse. We also discuss the importance for the chemical profiles expected in the outermost layers of ZZ Ceti stars of the computation of the thermally pulsing AGB phase and of the phase in which element diffusion is relevant. We find a strong dependence of the outer layer chemical stratification on the stellar mass. In particular, in the less massive models, the double-layered structure in the helium layer built up during the thermally pulsing AGB phase is not removed by diffusion by the time the ZZ Ceti stage is reached. Finally, we perform adiabatic pulsation calculations and discuss the implications of our new chemical profiles for the pulsational properties of ZZ Ceti stars. We find that the whole g-mode period spectrum and the mode-trapping properties of these pulsating white dwarfs as derived from our new chemical profiles are substantially different from those based on chemical profiles widely used in existing asteroseismological studies. Thus, we expect the asteroseismological models derived from our chemical profiles to be significantly different from those found thus far.Facultad de Ciencias Astronómicas y Geofísica

Pulsating hydrogen-deficient white dwarfs and pre-white dwarfs observed with TESS : III. Asteroseismology of the DBV star GD 358

Context. The collection of high-quality photometric data by space telescopes, such as the completed Kepler mission and the ongoing TESS program, is revolutionizing the area of white-dwarf asteroseismology. Among the different kinds of pulsating white dwarfs, there are those that have He-rich atmospheres, and they are called DBVs or V777 Her variable stars. The archetype of these pulsating white dwarfs, GD 358, is the focus of the present paper. Aims. We report a thorough asteroseismological analysis of the DBV star GD 358 (TIC 219074038) based on new high-precision photometric data gathered by the TESS space mission combined with data taken from the Earth. Methods. We reduced TESS observations of the DBV star GD 358 and performed a detailed asteroseismological analysis using fully evolutionary DB white-dwarf models computed accounting for the complete prior evolution of their progenitors. We assessed the mass of this star by comparing the measured mean period separation with the theoretical averaged period spacings of the models, and we used the observed individual periods to look for a seismological stellar model. We detected potential frequency multiplets for GD 358, which we used to identify the harmonic degree (`) of the pulsation modes and rotation period. Results. In total, we detected 26 periodicities from the TESS light curve of this DBV star using standard pre-whitening. The oscillation frequencies are associated with nonradial g(gravity)-mode pulsations with periods from ∼422 s to ∼1087 s. Moreover, we detected eight combination frequencies between ∼543 s and ∼295 s. We combined these data with a huge amount of observations from the ground. We found a constant period spacing of 39.25 ± 0.17 s, which helped us to infer its mass (M? = 0.588 ± 0.024 M ) and constrain the harmonic degree ` of the modes. We carried out a period-fit analysis on GD 358, and we were successful in finding an asteroseismological model with a stellar mass (M? = 0.584+0.025 −0.019 M ), compatible with the stellar mass derived from the period spacing, and in line with the spectroscopic mass (M? = 0.560 ± 0.028M ). In agreement with previous works, we found that the frequency splittings vary according to the radial order of the modes, suggesting differential rotation. Obtaining a seismological model made it possible to estimate the seismological distance (dseis = 42.85 ± 0.73 pc) of GD 358, which is in very good accordance with the precise astrometric distance measured by Gaia EDR3 (π = 23.244 ± 0.024, dGaia = 43.02 ± 0.04 pc). Conclusions. The high-quality data measured with the TESS space telescope, used in combination with data taken from ground-based observatories, provides invaluable information for conducting asteroseismological studies of DBV stars, analogously to what happens with other types of pulsating white-dwarf stars. The currently operating TESS mission, together with the advent of other similar space missions and new stellar surveys, will give an unprecedented boost to white dwarf asteroseismology

TESS first look at evolved compact pulsators : Asteroseismology of the pulsating helium-atmosphere white dwarf TIC 257459955

Context. Pulsation frequencies reveal the interior structures of white dwarf stars, shedding light on the properties of these compact objects that represent the final evolutionary stage of most stars. Two-minute cadence photometry from the Transiting Exoplanet Survey Satellite (TESS) records pulsation signatures from bright white dwarfs over the entire sky. Aims. As part of a series of first-light papers from TESS Asteroseismic Science Consortium Working Group 8, we aim to demonstrate the sensitivity of TESS data, by measuring pulsations of helium-atmosphere white dwarfs in the DBV instability strip, and what asteroseismic analysis of these measurements can reveal about their stellar structures. We present a case study of the pulsating DBV WD 0158−160 that was observed as TIC 257459955 with the two-minute cadence for 20.3 days in TESS Sector 3. Methods. We measured the frequencies of variability of TIC 257459955 with an iterative periodogram and prewhitening procedure. The measured frequencies were compared to calculations from two sets of white dwarf models to constrain the stellar parameters: the fully evolutionary models from LPCODE and the structural models from WDEC. Results. We detected and measured the frequencies of nine pulsation modes and eleven combination frequencies of WD 0158−160 to ∼0.01 µHz precision. Most, if not all, of the observed pulsations belong to an incomplete sequence of dipole (` = 1) modes with a mean period spacing of 38.1 ± 1.0 s. The global best-fit seismic models from both LPCODE and WDEC have effective temperatures that are &3000 K hotter than archival spectroscopic values of 24 100–25 500 K; however, cooler secondary solutions are found that are consistent with both the spectroscopic effective temperature and distance constraints from Gaia astrometry. Conclusions. Our results demonstrate the value of the TESS data for DBV white dwarf asteroseismology. The extent of the shortcadence photometry enables reliably accurate and extremely precise pulsation frequency measurements. Similar subsets of both the LPCODE and WDEC models show good agreement with these measurements, supporting that the asteroseismic interpretation of DBV observations from TESS is not dominated by the set of models used. However, given the sensitivity of the observed set of pulsation modes to the stellar structure, external constraints from spectroscopy and/or astrometry are needed to identify the best seismic solutions.Facultad de Ciencias Astronómicas y Geofísica

The anisotropic mechanical behaviour of electro-spun biodegradable polymer scaffolds: Experimental characterisation and constitutive formulation

Electro-spun biodegradable polymer fibrous structures exhibit anisotropic mechanical properties dependent on the degree of fibre alignment. Degradation and mechanical anisotropy need to be captured in a constitutive formulation when computational modelling is used in the development and design optimisation of such scaffolds.Biodegradable polyester-urethane scaffolds were electro-spun and underwent uniaxial tensile testing in and transverse to the direction of predominant fibre alignment before and after in vitro degradation of up to 28 days. A microstructurally-based transversely isotropic hyperelastic continuum constitutive formulation was developed and its parameters were identified from the experimental stress–strain data of the scaffolds at various stages of degradation.During scaffold degradation, maximum stress and strain in circumferential direction decreased from 1.02±0.23 MPa to 0.38±0.004 MPa and from 46±11% to 12±2%, respectively. In longitudinal direction, maximum stress and strain decreased from 0.071±0.016 MPa to 0.010±0.007 MPa and from 69±24% to 8±2%, respectively. The constitutive parameters were identified for both directions of the non-degraded and degraded scaffold for strain range varying between 0% and 16% with coefficients of determination r2>0.871. The six-parameter constitutive formulation proved versatile enough to capture the varying non-linear transversely isotropic behaviour of the fibrous scaffold throughout various stages of degradation

European Collaborative Action - Urban Air, Indoor Environment and Human Exposure, Report No 30, Framework for health-based ventilation guidelines in Europe

The present report describes the findings and recommendations of the HealthVent (Health-based ventilation guidelines for Europe) project that funded by the European Commission’s Directorate General for Health and Consumers in the framework of the Second Programme of Community Action in the Field of Health (2008-2013). HealthVent developed a framework for health-based ventilation guidelines for public and residential buildings in Europe and assessed the consequences of implementing these guidelines, bearing in mind future trends in the built environment, including energy efficiency and environmental sustainability issues.JRC.F.2-Consumer Products Safet

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival