Science in the Elementary Classroom

The elementary school day is filled with many different aspects of learning. Math and reading have been the emphasis of teaching over the last decade. Science is a part of students learning that needs to find its way into the elementary school day. This literature review compares different curriculum that is used to teach science in the elementary classroom as well as discusses an effective use of time to implement science into the daily schedule. When considering when and how to teach science, some teachers incorporate into other curricular areas as others find its own time during the day. Multiple studies were analyzed to determine the best curriculum and time to teach science as well as what professional development should include to help teachers feel confident in teaching science. Current literature suggests incorporating science into literature or in game form to help students with problem solving skills. Many skills taught and learned in elementary science carry over to essential skills for students to be successful in the world after school

Does Assurance on CSR Reporting Enhance Environmental Reputation? An Examination in the U.S. Context

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Highlights Just over 18 percent of our sample companies obtained outside assurance. Other factors, outside assurance is positively associated with environmental reputation scores. Positive impacts hold across different types of assurance providers

Mandated Social Disclosure : An Analysis of the Response to the California Transparency in Supply Chains Act of 2010

Peer reviewedPostprin

XIAP impairs Smac release from the mitochondria during apoptosis

X-linked inhibitor of apoptosis protein (XIAP) is a potent inhibitor of caspases 3, 7 and 9, and mitochondrial Smac (second mitochondria-derived activator of caspase) release during apoptosis inhibits the activity of XIAP. In this study we show that cytosolic XIAP also feeds back to mitochondria to impair Smac release. We constructed a fluorescent XIAP-fusion protein by labelling NH2- and COOH-termini with Cerulean fluorescent protein (C-XIAP-C). Immunoprecipitation confirmed that C-XIAP-C retained the ability to interact with Smac and impaired extrinsically and intrinsically activated apoptosis in response to tumour necrosis factor-related apoptosis-inducing ligand/cycloheximide and staurosporine. In C-XIAP-C-expressing cells, cytochrome c release from mitochondria proceeded normally, whereas Smac release was significantly prolonged and incomplete. In addition, physiological expression of native XIAP prolonged or limited Smac release in HCT-116 colon cancer cells and primary mouse cortical neurons. The Smac-binding capacity of XIAP, but not caspase inhibition, was central for mitochondrial Smac retention, as evidenced in experiments using XIAP mutants that cannot bind to Smac or effector caspases. Similarly, the release of a Smac mutant that cannot bind to XIAP was not impaired by C-XIAP-C expression. Full Smac release could however be provoked by rapid cytosolic C-XIAP-C depletion upon digitonin-induced plasma membrane permeabilization. Our findings suggest that although mitochondria may already contain pores sufficient for cytochrome c release, elevated amounts of XIAP can selectively impair and limit the release of Smac

Evolution of haplodiploidy: Models for inbred and outbred systems

Several new models are proposed for the evolution of haplodiploidy. Each of these models is evaluated for its ability to explain (1) special problems associated with transition to haplodiploidy from a population of diplodiploid progenitors, (2) current patterns of population structure in haplodiploid and related species, and (3) the evolution of genetic systems similar but not identical to haplodiploid systems. Of the new models, three are based on special conditions associated with inbreeding. Close inbreeding provides for the automatic effects of reduced problems in expressing recessives, lowered differences in gain from heterozygosity (to produce both heterotic effects and a greater variety of offspring) between haploid and diploid males, effective protection of haploids from direct competition with diploids, and a mechanism for the spread of haplodiploidy through gains derived from increased ability to control sex ratio. These models differ in the context where gain from sex ratio control is expressed. Pathways for the evolution of haplodiploidy in outbreeding populations are also discussed. Females who parthenogenetically produce haploid males have high genetic relatedness to their sons. If the sperm of these males is used to make both sons and daughters, i.e., through matings with diplodiploid females, there may be a net gain for haplodiploids. Another outbreeding model, modified from S. W. Brown (1964, Genetics 49, 797-817), deals with selection for females producing haploid males in populations where there are driving sex chromosomes. Biases created by drive in sex ratio may allow haplodiploid females to be the only effective producers of males in the population. Several of the new models explain the whole range of haplodiploid and related adaptations and provide predictions that appear to be more consistent with the known structure of contemporary populations than those available in current models.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23270/1/0000207.pd

Mackenzie Birkey, Western Kentucky University, 2018 After Dinner Speaking Event

Video of Mackenzie Birkey\u27s (Western Kentucky University) presentation for the final round of the After Dinner Speaking Event for the 2018 American Forensic Association National Individual Events Tournament held at Colorado College