827 research outputs found
Evaluating Maintainability Prejudices with a Large-Scale Study of Open-Source Projects
Exaggeration or context changes can render maintainability experience into
prejudice. For example, JavaScript is often seen as least elegant language and
hence of lowest maintainability. Such prejudice should not guide decisions
without prior empirical validation. We formulated 10 hypotheses about
maintainability based on prejudices and test them in a large set of open-source
projects (6,897 GitHub repositories, 402 million lines, 5 programming
languages). We operationalize maintainability with five static analysis
metrics. We found that JavaScript code is not worse than other code, Java code
shows higher maintainability than C# code and C code has longer methods than
other code. The quality of interface documentation is better in Java code than
in other code. Code developed by teams is not of higher and large code bases
not of lower maintainability. Projects with high maintainability are not more
popular or more often forked. Overall, most hypotheses are not supported by
open-source data.Comment: 20 page
A multiwavelength study on the high-energy behaviour of Fermi/LAT pulsars
Using archival as well as freshly acquired data, we assess the X-ray
behaviour of the Fermi/LAT gamma-ray pulsars listed in the First Fermi source
catalog. After revisiting the relationships between the pulsars' rotational
energy losses and their X and gamma-ray luminosities, we focus on the
distance-indipendent gamma to X-ray flux ratios. When plotting our Fgamma/Fx
values as a function of the pulsars' rotational energy losses, one immediately
sees that pulsars with similar energetics have Fgamma/Fx spanning 3 decades.
Such spread, most probably stemming from vastly different geometrical
configurations of the X and gamma-ray emitting regions, defies any
straightforward interpretation of the plot. Indeed, while energetic pulsars do
have low Fgamma/Fx values, little can be said for the bulk of the Fermi neutron
stars. Dividing our pulsar sample into radio-loud and radio-quiet subsamples,
we find that, on average, radio-quiet pulsars do have higher values of
Fgamma/Fx, implying an intrinsec faintness of their X-ray emission and/or a
different geometrical configuration. Moreover, despite the large spread
mentioned above, statistical tests show a lower scatter in the radio-quiet
dataset with respect to the radio-loud one, pointing to a somewhat more
constrained geometry for the radio-quiet objects with respect to the radio-loud
ones.Comment: 39 pages, 5 figures, 3 tables. To be published in Astrophysical
Journa
Rethinking Intergenerational Transmission(s): Does a Wellbeing Lens Help? The Case of Nutrition
The intergenerational transmission (IGT) of poverty is a well?established conceptualisation of how poverty is reproduced over time. IGT has been a popular approach but as currently constructed it tends to be overly deterministic, and to overly emphasise material assets. In contrast, ‘wellbeing’ is emerging as a complement to the more traditional ways of conceptualising and measuring poverty and deprivation around material consumption. Wellbeing extends attention from what people can do and be and adds how people feel about what they can do and be. Wellbeing is thus explicitly rather than inferentially about agency and also goes beyond the material to consider the relational and the subjective domains of life. So, can a wellbeing lens help us to rethink IGT? We use an application to an IGT mechanism: the transmission of undernutrition from one generation to the next
fMRI evidence of ‘mirror’ responses to geometric shapes
Mirror neurons may be a genetic adaptation for social interaction [1]. Alternatively, the associative hypothesis [2], [3] proposes that the development of mirror neurons is driven by sensorimotor learning, and that, given suitable experience, mirror neurons will respond to any stimulus. This hypothesis was tested using fMRI adaptation to index populations of cells with mirror properties. After sensorimotor training, where geometric shapes were paired with hand actions, BOLD response was measured while human participants experienced runs of events in which shape observation alternated with action execution or observation. Adaptation from shapes to action execution, and critically, observation, occurred in ventral premotor cortex (PMv) and inferior parietal lobule (IPL). Adaptation from shapes to execution indicates that neuronal populations responding to the shapes had motor properties, while adaptation to observation demonstrates that these populations had mirror properties. These results indicate that sensorimotor training induced populations of cells with mirror properties in PMv and IPL to respond to the observation of arbitrary shapes. They suggest that the mirror system has not been shaped by evolution to respond in a mirror fashion to biological actions; instead, its development is mediated by stimulus-general processes of learning within a system adapted for visuomotor control
POTs: Protective Optimization Technologies
Algorithmic fairness aims to address the economic, moral, social, and
political impact that digital systems have on populations through solutions
that can be applied by service providers. Fairness frameworks do so, in part,
by mapping these problems to a narrow definition and assuming the service
providers can be trusted to deploy countermeasures. Not surprisingly, these
decisions limit fairness frameworks' ability to capture a variety of harms
caused by systems.
We characterize fairness limitations using concepts from requirements
engineering and from social sciences. We show that the focus on algorithms'
inputs and outputs misses harms that arise from systems interacting with the
world; that the focus on bias and discrimination omits broader harms on
populations and their environments; and that relying on service providers
excludes scenarios where they are not cooperative or intentionally adversarial.
We propose Protective Optimization Technologies (POTs). POTs provide means
for affected parties to address the negative impacts of systems in the
environment, expanding avenues for political contestation. POTs intervene from
outside the system, do not require service providers to cooperate, and can
serve to correct, shift, or expose harms that systems impose on populations and
their environments. We illustrate the potential and limitations of POTs in two
case studies: countering road congestion caused by traffic-beating
applications, and recalibrating credit scoring for loan applicants.Comment: Appears in Conference on Fairness, Accountability, and Transparency
(FAT* 2020). Bogdan Kulynych and Rebekah Overdorf contributed equally to this
work. Version v1/v2 by Seda G\"urses, Rebekah Overdorf, and Ero Balsa was
presented at HotPETS 2018 and at PiMLAI 201
The Physics of turbulent and dynamically unstable Herbig-Haro jets
The overall properties of the Herbig-Haro objects such as centerline
velocity, transversal profile of velocity, flow of mass and energy are
explained adopting two models for the turbulent jet. The complex shapes of the
Herbig-Haro objects, such as the arc in HH34 can be explained introducing the
combination of different kinematic effects such as velocity behavior along the
main direction of the jet and the velocity of the star in the interstellar
medium. The behavior of the intensity or brightness of the line of emission is
explored in three different cases : transversal 1D cut, longitudinal 1D cut and
2D map. An analytical explanation for the enhancement in intensity or
brightness such as usually modeled by the bow shock is given by a careful
analysis of the geometrical properties of the torus.Comment: 17 pages, 10 figures. Accepted for publication in Astrophysics &
Spac
Geologic controls on gas hydrate occurrence in the Mount Elbert prospect, Alaska North Slope
This paper is not subject to U.S. copyright. The definitive version was published in Marine and Petroleum Geology 28 (2011): 589-607, doi:10.1016/j.marpetgeo.2009.12.004.Data acquired at the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well, drilled in the Milne Point area of the Alaska North Slope in February, 2007, indicates two zones of high gas hydrate saturation within the Eocene Sagavanirktok Formation. Gas hydrate is observed in two separate sand reservoirs (the D and C units), in the stratigraphically highest portions of those sands, and is not detected in non-sand lithologies. In the younger D unit, gas hydrate appears to fill much of the available reservoir space at the top of the unit. The degree of vertical fill with the D unit is closely related to the unit reservoir quality. A thick, low-permeability clay-dominated unit serves as an upper seal, whereas a subtle transition to more clay-rich, and interbedded sand, silt, and clay units is associated with the base of gas hydrate occurrence. In the underlying C unit, the reservoir is similarly capped by a clay-dominated section, with gas hydrate filling the relatively lower-quality sands at the top of the unit leaving an underlying thick section of high-reservoir quality sands devoid of gas hydrate. Evaluation of well log, core, and seismic data indicate that the gas hydrate occurs within complex combination stratigraphic/structural traps. Structural trapping is provided by a four-way fold closure augmented by a large western bounding fault. Lithologic variation is also a likely strong control on lateral extent of the reservoirs, particularly in the D unit accumulation, where gas hydrate appears to extend beyond the limits of the structural closure. Porous and permeable zones within the C unit sand are only partially charged due most likely to limited structural trapping in the reservoir lithofacies during the period of primary charging. The occurrence of the gas hydrate within the sands in the upper portions of both the C and D units and along the crest of the fold is consistent with an interpretation that these deposits are converted free gas accumulations formed prior to the imposition of gas hydrate stability conditions
Economic burden and comorbidities of attention-deficit/hyperactivity disorder among pediatric patients hospitalized in the United States
<p>Abstract</p> <p>Background</p> <p>This retrospective database analysis used data from the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample (NIS) to examine common primary diagnoses among children and adolescents hospitalized with a secondary diagnosis of attention- deficit/hyperactivity disorder (ADHD) and assessed the burden of ADHD.</p> <p>Methods</p> <p>Hospitalized children (aged 6-11 years) and adolescents (aged 12-17 years) with a secondary diagnosis of ADHD were identified. The 10 most common primary diagnoses (using the first 3 digits of the ICD-9-CM code) were reported for each age group. Patients with 1 of these conditions were selected to analyze demographics, length of stay (LOS), and costs. Control patients were selected if they had 1 of the 10 primary diagnoses and no secondary ADHD diagnosis. Patient and hospital characteristics were reported by cohort (i.e., patients with ADHD vs. controls), and LOS and costs were reported by primary diagnosis. Multivariable linear regression analyses were undertaken to adjust LOS and costs based on patient and hospital characteristics.</p> <p>Results</p> <p>A total of 126,056 children and 204,176 adolescents were identified as having a secondary diagnosis of ADHD. Among children and adolescents with ADHD, the most common diagnoses tended to be mental health related (i.e., affective psychoses, emotional disturbances, conduct disturbances, depressive disorder, or adjustment reaction). Other common diagnoses included general symptoms, asthma (in children only), and acute appendicitis. Among patients with ADHD, a higher percentage were male, white, and covered by Medicaid. LOS and costs were higher among children with ADHD and a primary diagnosis of affective psychoses (by 0.61 days and 940), or depressive disorder (by 0.41 days and 352), depressive disorder (by 0.94 days and 1,330), emotional disturbances (by 1.45 days and 702), and neurotic disorders (by 1.60 days and $541) versus controls.</p> <p>Conclusion</p> <p>Clinicians and health care decision makers should be aware of the potential impact of ADHD on hospitalized children and adolescents.</p
The yeast high mobility group protein HMO2, a subunit of the chromatin-remodeling complex INO80, binds DNA ends
DNA damage is a common hazard that all cells have to combat. Saccharomyces cerevisiae HMO2 is a high mobility group protein (HMGB) that is a component of the chromatin-remodeling complex INO80, which is involved in double strand break (DSB) repair. We show here using DNA end-joining and exonuclease protection assays that HMO2 binds preferentially to DNA ends. While HMO2 binds DNA with both blunt and cohesive ends, the sequence of a single stranded overhang significantly affects binding, supporting the conclusion that HMO2 recognizes features at DNA ends. Analysis of the effect of duplex length on the ability of HMO2 to protect DNA from exonucleolytic cleavage suggests that more than one HMO2 must assemble at each DNA end. HMO2 binds supercoiled DNA with higher affinity than linear DNA and has a preference for DNA with lesions such as pairs of tandem mismatches; however, comparison of DNA constructs of increasing length suggests that HMO2 may not bind stably as a monomer to distorted DNA. The remarkable ability of HMO2 to protect DNA from exonucleolytic cleavage, combined with reports that HMO2 arrives early at DNA DSBs, suggests that HMO2 may play a role in DSB repair beyond INO80 recruitment
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