Correction to "Long-term and recent changes in sea level in the Falkland Islands"

In the paper “Long-term and recent changes in sea level in the Falkland Islands” by P. L. Woodworth et al. (Journal of Geophysical Research, 115, C09025, doi:10.1029/2010JC006113, 2010), in paragraph 47 we adopted a value of −0.52 mm/yr for the estimated rate of present-day sea level change in the Falkland Islands due to glacial isostatic adjustment (GIA). This value was used to remove the contributions of GIA to our measurements of historical and recent rates of sea level change. However, it was based on a misreading of the data file of Peltier [2004] on the Permanent Service for Mean Sea Level Web site (http://www.psmsl.org/train_and_info/geo_signals/gia/peltier). More reasonable values to apply to the observed changes since the mid-nineteenth century and in recent years would be −0.69 and −0.61 mm/yr respectively. Consequently, the long-term rate of sea level change between 1842 and the early 1980s, after correction for air pressure effects and for GIA, reported as +0.75 ± 0.35 mm/yr in paragraphs 1, 47, 55, and 61 should be +0.92 ± 0.35 mm/yr, the corresponding rate between 1842 and the midpoint of recent data of 1.06 ± 0.22 mm/yr in paragraphs 48 and 55 should be 1.23 ± 0.22 mm/yr, and the corresponding rate since 1992 reported as 2.51 ± 0.58 mm/yr in paragraphs 1 and 52 becomes 2.60 ± 0.58 mm/yr. The middle of paragraph 63 becomes “The Stanley data suggest that the rate of change of sea level in East Falkland since 1992 has been approximately 2.6 mm/yr, a rate supported by information from satellite altimetry.” These small GIA model corrections have no bearing on the main findings of our paper on the difference in the rates of sea level change between the historical (1842 to present-day) and recent (last 2 decades) epoch

Conformation-dependent GAD65 autoantibodies in diabetes

Aims/hypothesis. Conformation-dependent autoantibodies directed against GAD65 are markers of Type 1 diabetes. In this study we aimed to determine whether the substitution of GAD65 with GAD67 amino acids would affect the binding of conformation-dependent GAD65 autoantibodies. Methods. We used PCR-based site-directed mutagenesis to generate a series of mutated GAD65 cDNA constructs in which specific GAD65 coding sequences for regions of the protein critical for autoantibody binding were replaced with GAD67 coding sequences. Results. The introduction of a point mutation at position 517, substituting glutamic acid with proline, markedly reduced the binding of disease-associated GAD65 antibodies. The binding of GAD65 antibodies to the E517P mutant was reduced in the sera of all newly diagnosed Type 1 diabetes patients (n=85) by a mean of 72% (p<0.0001) compared with binding to wild-type GAD65. Patients with latent autoimmune diabetes in adults (n=24) showed a similar reduction in binding (79% reduction, p<0.0001). First-degree relatives who subsequently progressed to Type 1 diabetes (n=12) showed a reduction in binding of 80% compared with a reduction of only 65% among relatives who had not progressed to disease (n=38; p=0.025). In healthy GAD65Ab-positive individuals who did not progress to diabetes during a 9-year follow-up period (n=51), binding to GAD65-E517P was reduced by only 28% compared with binding to wild-type GAD65. Conclusions/interpretation. Differences in autoantibody binding to wild-type GAD65 versus GAD65-E517P may provide predictive information about Type 1 diabetes risk beyond that provided by the presence or absence of GAD65 autoantibodies. Lack of binding to mutant GAD65-E517P defines GAD65-positive individuals who are at higher risk of developing diabetes

An assessment of static Precise Point Positioning using GPS only, GLONASS only, and GPS plus GLONASS

The aim of this paper is to look into the achievable repeatability and accuracy from Precise Point Positioning (PPP) daily solutions when using GPS only (PPP GPS), GLONASS only (PPP GLO), and GPS plus GLONASS (PPP GPS+GLO) for static positioning. As part of the assessment, a comparison with global double difference (DD) GPS daily solutions is presented. It is shown, therefore, that all of the PPP daily solutions can achieve millimetric level repeatability, similar to the global DD GPS solutions. Furthermore, the mean of the biases between the PPP daily solutions and the global DD GPS daily solutions are constellation type dependent, while an improvement is found in the vertical component for PPP GPS+GLO over PPP GLO, as the latter may be more affected by any imperfections in the models for GLONASS antenna phase centre variations. It is concluded that PPP GLO daily solutions have the ability to be used as independent solutions to PPP GPS daily solutions for static positioning, and as an alternative to PPP GPS+GLO or global DD GPS daily solutions

Long-term and recent changes in sea level in the Falkland Islands

Mean sea level measurements made at Port Louis in the Falkland Islands in 1981-2, 1984 and 2009, together with values from the nearby permanent tide gauge at Port Stanley, have been compared to measurements made at Port Louis in 1842 by James Clark Ross. The long-term rate of change of sea level is estimated to have been +0.75 ± 0.35 mm/year between 1842 and the early 1980s, after correction for air pressure effects and for vertical land movement due to Glacial Isostatic Adjustment (GIA). The 2009 Port Louis data set is of particular importance due to the availability of simultaneous information from Port Stanley. The data set has been employed in two ways, by providing a short recent estimate of mean sea level itself, and by enabling the effective combination of measurements at the two sites. The rate of sea level rise observed since 1992, when the modern Stanley gauge was installed, has been larger at 2.51 ± 0.58 mm/year, after correction for air pressure and GIA. This rate compares to a value of 2.79 ± 0.42 mm/year obtained from satellite altimetry in the region over the same period. Such a relatively recent acceleration in the rate of sea level rise is consistent with findings from other locations in the southern hemisphere and globall

Virtual geometric realization of woven textile composites

Several methods for describing meso-mechanical virtual domains of woven textiles exist. Such approaches utilize equations conjured directly from independent textile manufacturing/machining processes. Therefore, extensions beyond cases considered by the originating authors is technically challenging because it requires machining process experience. Consequently, an intuitive, yet simple, method for developing a variety of complex woven textiles is desirable. The proposed approach uses a simplistic geometric philosophy similar to Peirce's. Nevertheless, it implements advancedcross-sectional shape functions such as power-elliptical functions etc., capable of describing a plethora of cross-sections. Also, non-circular arcs, adapted from local cross-sectional geometry of yarns, are used to define yarn paths. In addition, more complex woven fabrics such as 3D angle and orthogonal interlocking textiles are considered. Generation of desired woven fabrics is defined by a set of inherent physical geometric arguments which are implemented using numerical techniques. This numerical solution strategy, based on physical arguments, negates the requirement of defining equations restricted to specific textiles, making the proposed technique universally adaptable. The requisite arguments of this approach are implemented in MATLAB using an in-house algorithm, TextCompGen. It receives arguments about desired textile architectures, and outputs MATLAB-based plots of the expected geometry alongside a complementary Python-script for automatically re-creating the same geometry in ABAQUS/CAE—a widely-used finite element (FE) preprocessor. The latter feature is included to facilitate subsequent FE analyses, if required

GAD65 Autoantibody Responses in Japanese Latent Autoimmune Diabetes in Adult Patients

OBJECTIVE—To determine whether development of insulin requirement in patients with latent autoimmune diabetes in adults (LADA) is accompanied with the emergence of a type 1 diabetes–like autoimmune response