Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease

BACKGROUND: To evaluate the macrophage migration inhibitory factor and E-selectin levels in patients with acute coronary syndrome. MATERIALS/METHODS: We examined the plasma migration inhibitory factor and E-selectin levels in 87 patients who presented with chest pain at our hospital. The patients were classified into two groups according to their cardiac status. Sixty-five patients had acute myocardial infarction, and 22 patients had non-cardiac chest pain (non-coronary disease). We designated the latter group of patients as the control group. The patients who presented with acute myocardial infarction were further divided into two subgroups: ST-elevated myocardial infarction (n = 30) and non-ST elevated myocardial infarction (n = 35). RESULTS: We found higher plasma migration inhibitory factor levels in both acute myocardial infarction subgroups than in the control group. However, the E-selectin levels were similar between the acute myocardial infarction and control patients. In addition, we did not find a significant difference in the plasma migration inhibitory factor levels between the ST elevated myocardial infarction and NST-elevated myocardial infarction subgroups. DISCUSSION: The circulating concentrations of migration inhibitory factor were significantly increased in acute myocardial infarction patients, whereas the soluble E-selectin levels were similar between acute myocardial infarction patients and control subjects. Our results suggest that migration inhibitory factor may play a role in the atherosclerotic process

Comparison of pre- and post-levothyroxine high-sensitivity c-reactive protein and fetuin-a levels in subclinical hypothyroidism

OBJECTIVE: The objective of this trial was to determine the levels of inflammatory markers, high-sensitivity C-reactive protein and fetuin-A pre- and post-levothyroxine treatment in cases of subclinical hypothyroidism. MATERIALS AND METHODS: A total of 32 patients with a diagnosis of subclinical hypothyroidism and a control group of 30 healthy individuals were tested for high-sensitivity C-reactive protein and fetuin-A, followed by the administration of 50 µg of levothyroxine in the patient group for 3 months. During the post-treatment stage, high-sensitivity C-reactive protein and fetuin-A levels in the patient group were re-assessed and compared with pre-treatment values. RESULTS: Pre-treatment levels of both high-sensitivity C-reactive protein and fetuin-A were observed to be higher in the patient group than in the control group. The decrease in high-sensitivity C-reactive protein levels during the post-treatment stage was not statistically significant. However, the decrease observed in post-treatment fetuin-A levels was found to be statistically significant. CONCLUSION: The decrease in fetuin-A levels in subclinical hypothyroidism cases indicates that levothyroxine treatment exerts anti-inflammatory and anti-apoptotic effects. Although the decrease in high-sensitivity C-reactive protein levels was statistically non-significant, it is predicted to reach significance with sustained treatment

The effect of helicobacter pylori eradication on macrophage migration inhibitory factor, c-reactive protein and fetuin-a levels

OBJECTIVES: To determine the effect of Helicobacter pylori (H. pylori) eradication on blood levels of high-sensitivity C-reactive protein (hs-CRP), macrophage migration inhibitory factor and fetuin-A in patients with dyspepsia who are concurrently infected with H. pylori. METHODS: H.pylori infection was diagnosed based on the 14C urea breath test (UBT) and histology. Lansoprazole 30 mg twice daily, amoxicillin 1 g twice daily, and clarithromycin 500 mg twice daily were given to all infected patients for 14 days; 14C UBT was then re-measured. In 30 subjects, migration inhibitory factor, fetuin-A and hs-CRP levels were examined before and after the eradication of H. pylori infection and compared to levels in 30 healthy subjects who tested negative for H. pylori infection. RESULTS: Age and sex distribution were comparable between patients and controls. Migration inhibitory factor and hs-CRP levels were higher, and fetuin-A levels were lower, in H. pylori-infected patients (p<0.05). Following eradication of H. pylori, migration inhibitory factor and hs-CRP levels were significantly decreased, whereas fetuin-A levels were increased. However, eradication of the organism did not change lipid levels (p>0.05). CONCLUSION: These findings suggest that H. pylori eradication reduces the levels of pro-inflammatory cytokines such as migration inhibitory factor and hs-CRP and also results in a significant increase in anti-inflammatory markers such as fetuin-A

Intraosseous cavernous hemangioma in the mandible: a case report

Intraosseous vascular lesions are rare conditions. They are most commonly seen in the vertebral column and skull; nevertheless, the mandible is a quite rare location. In this report, we present a case of intraosseous cavernous hemangioma in the mandible and discuss the clinical and radiological features. A 28-year-old male patient attended to our clinic with a complaint of painless swelling of mandible. Clinical evaluation revealed a bone-hard, smooth-surfaced, immobile mass in the left mandibular lingual area. The patient was evaluated with panoramic and occlusal radiography and computed tomography. The lesion surgically excised and pathological examination revealed an intraosseous cavernous hemangioma. Follow-up imaging 1 year later with cone beam computed tomography revealed recurrence of the lesion. The conclusion of this paper; when a bone hard, well-shaped mass was seen in the mandible, the possibility of intraosseous hemangioma must be remembered and before surgical procedure detailed radiographic evaluation should be performed

Bir Zanaatkârlık Araştırması: “Emeğin Karşılığı"

Bu çalışmanın temel amacı, zanaatkarların iktisadi ve sosyal hayatları bağlamında el emeğinin değer ve zihniyet dünyalarında nasıl konumlandığını anlamaya ve açıklamaya çalışmaktır. Çalışma, parçası olduğu araştırma hasebiyle, zanaatkarlığın anlamlı iş nosyonunu temsil ettiği varsayımına dayanmaktadır. İlk bölüm, çalışmanın ontolojik ve epistemolojik konumu ile kuramsal dayanağını açıklamaktadır. Devamında bu kuramsal dayanağı inşa eden bazı yorumcu sosyoloji kuramları ile yabancılaşma teorisi, değerler ve gündelik hayat sosyolojisinden bahsedilmektedir. Ardından, zanaat ve zanaatkarlık kavramlarının ve saha araştırmasının ekseninde yer alan, çalışma için önemli bazı kavramların literatür taramasına yer verilmiştir. Bu amaçla emek, zaman ve tecrübe kavramlarıyla zanaatkarlığa dair zihniyet bağının nasıl kurulduğu açıklanmaktadır. İkinci bölüm genel metodolojik bilgilere ayrılmaktadır. Üçüncü bölümde ise görüşmelerden elde edilen bulgular sınıflandırılarak betimsel analiz yöntemiyle yorumlanmaktadır. Zanaatkarlıkta ‘emeğin karşılığı’, mesleğin şahsî niteliklerinde içkin değerler marifetiyle belirlenen bir mefhumdur. Bu şahsî nitelikler, ani değişimlerle karakterize olan güncel piyasada zanaatkarlığı zorlaştıran özelliklere dönüşmekle birlikte aslında zanaatkarlığın sürdürülmesindeki manevi/kültürel direnç noktalarıdır. Zanaatkarlar arasında insan ilişkilerinin önemini ekonomik getirinin önünde tutmak, daha uygun bir zanaatkara müşteriyi yönlendirmek, el emeğinin kutsiyetine olan inançla hareket etmek gibi tutumlar hâlâ oldukça yaygındır. Bununla birlikte el emeğinin piyasada karşılık bulamaması ustaların mesleği bırakmalarına ya da mesleği sürdürseler de “cemiyete küsmelerine” sebep olmaktadır

Retrospective Evaluation of the Gubernacular Tract in Impacted%252FUnerupted Teeth with Cone-Beam Computed Tomography

Aim%253A Gubernaculum dentis guides the tooth eruption. This formation, which disappears after teething, continues to exist in impacted teeth. This study aimed to evaluate the gubernacular tract in patients with impacted%252Funerupted teeth who had previously received Cone-beam Computed Tomography (CBCT) for a variety of reasons. Material and Methods%253A In this study, the presence and characteristics of the gubernacular tract were evaluated according to age, gender, tooth groups, root development stages and positions of the teeth. 231 patients were included in this study. A total of 431 teeth were evaluated and the mean age of the patients was 28.0plusmn%253B0.90. Impacted teeth were classified according to their location. The presence and features of the gubernacular tract were evaluated using CBCT. Results%253A In the study, the presence of gubernacular tract was most common in canines. The mesioangular and vertical position of impacted teeth exhibited higher gubernacular tract presence, and these data were statistically significant. (Plt%253B0.05) Conclusion%253A This study stated that the frequency of incidence in the tooth groups was evaluated separately, it was determined that the incidence in canine teeth was significantly higher. Characteristics gubernacular tract such as no change, obliteration or contraction are more common in impacted teeth in vertical and mesioangular positions. This process may affect the impact of permanent teeth, but more studies with clinical follow-up are needed to reach definitive conclusions

Evaluation of Rosenmuller Fossa with cone beam computed tomography: A retrospective radio-anatomical study

Background: Rosenmuller fossa (RF) is known as a lateral pharyngeal recess, is bilaterally located beneath the skull base and behind the torus tubarius. Nasopharyngeal carcinoma is most commonly located in the RF. The purpose of this study is to evaluation of RF with cone beam computed tomography&nbsp;Methods: A total of 150 subjects (80 females, 70 males, 6-88 years) were included in the study. Subjects were divided into age groups (6- 20 years, 21-30 years, 31-40 years, 41-50 years, 51-60 years, over 60 years) and gender.&nbsp;Result: There is no statistically significant difference between class (RF type) and gender (p = 0.086). There is a statistically significant association between the categories of age group and class variables (p = 0.015). RF type 1 was more common in the 6-20 age and 21-30 age groups, whereas RF type 3 was more common in the 41-50 age and 51-60 age groups.&nbsp;Conclusion: When the literature was investigated, it was not found a study evaluating RF with cone beam computed tomography. When considering clinical significance, RF should be searched and examined in larger populations.&nbsp;KEYWORDS&nbsp; Cone beam computed tomography, Rosenmuller&nbsp; Fossa, Nasopharyngeal Carcinom

Derin öğrenme yöntemi ile panoramik radyografiden diş eksikliklerinin tespiti: Bir yapay zekâ pilot çalışması

Amaç: Bu çalışmanın amacı, panoramik radyografide diş eksikliklerinin değerlendirilmesi için tasarlanmış tanı amaçlı bilgisayar yazılımının işlevini geliştirmek ve değerlendirmektir.Gereç ve Yöntemler: Veri seti eksik diş tespiti için 99 tam diş ve 54 eksik diş olmak üzere 153 görüntüden oluşmaktadır. Tüm görüntüler Ağız, Diş ve Çene Radyolojisi uzmanları tarafından tekrar kontrol edilmiş ve doğrulanmıştır. Veri setindeki tüm görüntüler eğitim öncesinde 971 X 474 piksel olarak yeniden boyutlandırılmıştır. Açık kaynak kodlu python programlama dili ve OpenCV, NumPy, Pandas, ile Matplotlib kütüphaneleri etkin olarak kullanılarak bir rastgele dizilim oluşturulmuştur. Önceden eğitilmiş bir Google Net Inception v3 CNN ağı ön işleme için kullanılmış ve veri setleri transfer öğrenimi kullanılarak eğitilmiştir.Bulgular: Eğitim de kullanılan görüntülerin modeli tahminlendirmesi ile çıkan başarı oranı % 94.7’dir. Eğitimde kullanılmayan test için ayrılan görüntülerin tahminlemesindeki başarı oranı % 75’dir. Sonuç: Derin öğrenme tekniklerinde veri seti arttıkça başarı oranları da artmaktadır. Daha fazla görüntüyle oluşacak veri setininin eğitim modellerinde başarı oranları yükselecektir. Gelecek çalışmalar daha büyük veri setleriyle yapılmalıdır.ANAHTAR KELİMELER Panoramik radyografi, derin öğrenme, yapay zek

SUCCESS OF ARTIFICIAL INTELLIGENCE SYSTEM IN DETERMINING ALVEOLAR BONE LOSS FROM DENTAL PANORAMIC RADIOGRAPHY IMAGES

Objectives: The aim of this study was to detect alveolar bone loss from dental panoramic radiographic images using artificial intelligence systems. Material and Methods: A total of 2276 panoramic radiographic images were used in this study. While 1137 of them belong to cases with bone destruction, 1139 were periodontally healthy. The dataset is divided into three parts as training (n=1856) , validation (n=210) and testing set (n= 210). All images in the data set were resized to 1472x718 pixels before training. A random sequence was created using the open-source python programming language and OpenCV, NumPy, Pandas, and Matplotlib libraries effectively. A pre-trained Google Net Inception v3 CNN network was used for preprocessing and data sets were trained using transfer learning. Diagnostic performance was evaluated with the confusion matrix using sensivitiy, specificity, precision, accuracy and F1 score. Results: Of the 105 cases with bone loss, 99 were detected by the AI system. Sensitivity was 0.94, specificity 0.88, precision 0.89, accuracy 0.91 and F1 score 0.91. Conclusion: The convolutional neural network model is successful in determining periodontal bone losses. It can be used as a system to facilitate the work of physicians in diagnosis and treatment planning in the future