Nonlinear analysis for proposing limit state criteria of reinforced concrete road bridge superstructures

In the research of long-time operating road bridge superstructures, it should note that when the internal forces in the beam elements reach specific values, the stiffness of the cross-section of these elements should decrease. Besides that, if there are damaged places in the beam-element of the road bridge superstructures, the element could not work normally, and the redistribution of internal forces between elements in the whole system would happen. This phenomenon was not taken into account in the initial design calculation. In practice, it shows that many road bridges are subjected to greater loads than the calculated loads in the design process, but they still normally operate. This article proposes the other limit state criteria in evaluating the load capacity reserve of road-bridge superstructures using nonlinear analysis based on nonlinear deformational models of modern construction codes. The proposed calculation procedure is established to explain the load capacity reserve of long-time operating road bridge superstructures in the case of the lack of experimental evaluation. From the obtained results, the suitable limit state criteria for road bridge superstructures are suggested, and the conclusions about the accuracy of the proposed approach of nonlinear structural analysis are recommended

Geometrically nonlinear buckling analysis of truss with length imperfection subjected to mechanical and thermal load using hybrid FEM

This paper presents a novel hybrid FEM-based approach to establish the mathematical model for solving the nonlinear buckling problem of truss systems with length imperfection under mechanical and thermal load. due to constant temperature change-based hybrid FEM. The proposed approach deals with establishing hybrid types of truss elements, including perfect truss elements without thermal deformation and truss elements with length imperfection and thermal deformation. The equilibrium equation of both truss elements is established based on compatibility relationships considering geometric nonlinearity. The hybrid global equilibrium equations of truss systems are developed by assembling constructed perfect truss elements without thermal deformation and truss elements with length imperfection and thermal deformation. The incremental-iterative algorithm based on the arc-length method is used to establish calculation programs to solve the hybrid global equilibrium equation for investigating the geometrically nonlinear buckling behavior of the truss system. The numerical test is presented to investigate the buckling and post-buckling behavior of truss systems having some elements with length imperfection under thermal and mechanical load

SECONDARY METABOLITES FROM MICROMONOSPORA SP. (G044)

In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô - Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 – 6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml

Secondary metabolites from Micromonospora ectrinospora G017

Eight  compounds, cyclo-(Pro-Tryp) (1), N-[2-(1H-indol-3-yl)-2-oxo-ethyl] acetamide (2), cyclo-(Pro-Tyr) (3), cyclo-(Pro-Phe) (4), cyclo-trans-4-OH-(Pro-Phe) (5), cyclo-(Pro-Leu) (6), cyclo-(Pro-Val) (7), and  uracil (8) were isolated from the culture broth of the marine Micromonospora ectrinospora G017 strain. The structures of the isolated compounds were established on the basis of their spectral data, including mass spectrometry and NMR

SIMULATION AS A TEACHING METHOD FOR NURSING EDUCATION IN HEALTHCARE-ASSOCIATED INFECTION PREVENTION AND CONTROL IN ASIAN COUNTRIES: A QUALITATIVE STUDY

BACKGROUND: Applying simulation for nursing education, especially in healthcare-associated infection prevention and control (HAI-PC) in developing countries has limited evidence. The study was conducted to explore educators’ perceptions of simulation as a teaching method for nursing education in HAI-PC in two Vietnamese and two Cambodian universities. METHODS: An exploratory qualitative design was applied. A focus group of 37 educators from four universities was conducted for data collection. Inductive and deductive qualitative content analysis was applied in analysing the data. RESULTS: The core category was constructed to reflect educators’ perception of scenario-based simulation (SBS) as a teaching method for nursing education in HAI prevention and control. This main category included three subcategories: (i) enhancing nursing competence; (ii) preparing students for simulation; and [1] promoting simulation pedagogy competence. CONCLUSIONS: The findings identified the importance and benefits of applying simulation as a teaching method in nursing education. Additionally, it emphasized the necessity of enhancing knowledge associated with HAIs and providing additional training on simulation for educators to improve the quality of conducting simulations

EXPERIENCES OF THE NURSING STUDENT IN LEARNING HAI PREVENTION AND CONTROL IN ASIAN COUNTRIES THROUGH THE USE OF SCENARIO-BASED SIMULATION: AN EXPLORATIVE QUALITATIVE STUDY

BACKGROUND: Healthcare-associated infections (HAIs) have posed a major threat to both patients and to the safety healthcare personnel worldwide. According to the World Health Organization, 10% of hospitalized patients are affected by HAIs worldwide. OBJECTIVE: The objective of this study was to explore the experiences of nursing students in learning HAIs prevention and control by the application of the scenario-based simulation pedagogy now in use in two Vietnamese and two Cambodian universities. METHODS: A qualitative study was conducted among 160 nursing students from 2 Cambodian universities and 2 Vietnamese universities, and by using the purposive-sampling method. The data were collected through a focus group discussion and analyzed by the Graneheim and Lundman method (Graneheim & Lundman, 2004). RESULTS: Two themes and six categories were generated. 1) First theme: factors for enhancing student learning on the prevention and control of HAIs by use of scenario-based simulation; and 2) Second theme: factors hindering students learning on HAI prevention and control by use of scenario-based simulation. CONCLUSION: The findings showed that SBS is an effective learning method for nursing students that can be applied to enhance the quality of nursing education in the Asian countries as SBS not only improves the clinical skills, but also the soft skills of nursing students. However, the effective outcomes and impacts can only be achieved in the context with the appropriate learning materials and equipment, simulation facilities and the instructors with pedagogical skills

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Hybrid finite element formulation for geometrically nonlinear buckling analysis of truss with initial length imperfection

This paper presents a novel hybrid FEM-based approach for nonlinear buckling analysis of truss with initial length imperfection. The contribution deals with establishing two types of truss finite element (perfection and imperfection element) considering large displacement based on displacement formulation and mixed formulation. Therefore, the hybrid global equation system is developed by assembling perfection and imperfection truss elements. The incremental-iterative algorithm based on the arc-length method is used to establish calculation programs for solving geometrically nonlinear buckling analysis of truss with initial length imperfection. Using a written calculation program, the numerical test is presented to investigate the equilibrium path for plan truss with initial member length imperfection

Penalty function method for geometrically nonlinear buckling analysis of imperfect truss with multi-freedom constraints based on mixed FEM

This paper is concerned with the approach to implementing the Penalty function method for imposing multi-freedom constraints in geometrically nonlinear analysis of imperfect trusses based on mixed finite element formulation. Using a finite element model based on displacement formulation, it is required to incorporate both the dependent boundary relations and initial length imperfection to the nonlinear master stiffness system of equations for solving the geometrically nonlinear problem of imperfect truss with multi-freedom constraints. For decreasing the mathematical complexion of the incorporating process, the author proposes a novel mixed finite truss element considering initial imperfection, used in building the model for solving the geometrically nonlinear problem of truss with multi-freedom constraints. The modified nonlinear stiffness equation is constructed by employing the penalty function method to convert a constrained problem into an unconstrained problem by extremizing the augmented energy function established based on the proposed mixed finite element formulation. For solving the nonlinear equilibrium equation of imperfect trusses with multi-freedom constraints, the incremental equilibrium equation is constructed, and the incremental-iterative algorithm for calculation is established utilizing the arc-length method, used for writing the calculation program for investigating geometrically nonlinear behavior of imperfect truss with multi-freedom constraints. The results of the numerical test show the influence of initial imperfection and choosing weight values on the equilibrium path of the truss

Augmented Lagrangian method for imposing nonlinear multi freedom constraints in static analysis for frames using FEM

This paper focuses on the treatment of nonlinear multi freedom constraints using an augmented Lagrangian method in finite element analysis of frames. The process of imposing boundary constraints is developed by changing the assembly stiffness equation to produce a modified system of equation considering nonlinear multi freedom constraints. For imposing the nonlinear constraints two better methods are the penalty augmentation method and Lagrange multiplier adjunction method. But there are not free of disadvantages. Using penalty method has a disadvantage in the choice appropriate weight values that balance solution accuracy with the violation of constraint conditions. Using the Lagrange multiplier adjunction method requires additional unknowns, and more complicated storage allocation procedures. This research proposes the connection between these methods using the augmented Lagrangian method for imposing the nonlinear multi freedom constraints in finite element analysis of frame. Based on the Newton Raphson method the incremental-iterative algorithm for solving the nonlinear balanced equations is established