3,191 research outputs found
Inspiratory threshold loading reduces lipoperoxidation in obese and normal-weight subjects
Obesity is related to increased oxidative stress. Although low-intensity physical exercise reduces oxidative stress, obese subjects may show exercise intolerance. For these subjects, inspiratory threshold loading could be an alternative tool to reduce oxidative stress. We investigated the effects of inspiratory threshold loading on biomarkers of oxidative stress in obese and normal-weight subjects. Twenty obese (31.4 ± 6 years old, 10 men and 10 women, 37.5 ± 4.7 kg/m2) and 20 normal-weight (29.4 ± 8 years old, 10 men and 10 women, 23.2 ± 1.5 kg/m2) subjects matched for age and gender participated in the study. Maximal inspiratory pressure (MIP) was assessed by a pressure transducer. Blood sampling was performed before and after loading and control protocols to assess thiobarbituric acid reactive substances (TBARS), protein carbonylation, and reduced glutathione. Inspiratory threshold loading was performed at 60% MIP and maintained until task failure. The 30-min control protocol was performed at 0 cmH2O. Our results demonstrated that inspiratory threshold loading reduced TBARS across time in obese (6.21 ± 2.03 to 4.91 ± 2.14 nmol MDA/ml) and normal-weight subjects (5.60 ± 3.58 to 4.69 ± 2.80 nmol MDA/ml; p = 0.007), but no change was observed in protein carbonyls and glutathione in both groups. The control protocol showed no significant changes in TBARS and protein carbonyls. However, reduced glutathione was increased across time in both groups (obese: from 0.50 ± 0.37 to 0.56 ± 0.35 μmol GSH/ml; normal-weight: from 0.61 ± 0.11 to 0.81 ± 0.23 μmol GSH/ml; p = 0.002). These findings suggest that inspiratory threshold loading could be potentially used as an alternative tool to reduce oxidative stress in both normal-weight and obese individuals
Regge behavior saves string theory from causality violations
Higher-derivative corrections to the Einstein-Hilbert action are present in bosonic string theory leading to the potential causality violations recently pointed out by Camanho et al. [1]. We analyze in detail this question by considering high-energy string-brane collisions at impact parameters b ≤ l s (the string-length parameter) with l s ≫ R p (the characteristic scale of the D p -brane geometry). If we keep only the contribution of the massless states causality is violated for a set of initial states whose polarization is suitably chosen with respect to the impact parameter vector. Such violations are instead neatly avoided when the full structure of string theory — and in particular its Regge behavior — is taken into account
Z-extremization and F-theorem in Chern-Simons matter theories
The three dimensional exact R symmetry of N=2 SCFTs extremizes the partition
function localized on a three sphere. Here we verify this statement at weak
coupling. We give a detailed analysis for two classes of models. The first one
is an SU(N)_k gauge theory at large k with both fundamental and adjoint matter
fields, while the second is a flavored version of the ABJ theory, where the CS
levels are large but they do not necessarily sum up to zero. We study in both
cases superpotential deformations and compute the R charges at different fixed
points. When these fixed points are connected by an RG flow we explicitly
verify that the free energy decreases at the endpoints of the flow between the
fixed points, corroborating the conjecture of an F-theorem in three dimensions.Comment: 28 pages, 3 figures, JHEP.cls, minor corrections, references adde
Corner contributions to holographic entanglement entropy
The entanglement entropy of three-dimensional conformal field theories
contains a universal contribution coming from corners in the entangling
surface. We study these contributions in a holographic framework and, in
particular, we consider the effects of higher curvature interactions in the
bulk gravity theory. We find that for all of our holographic models, the corner
contribution is only modified by an overall factor but the functional
dependence on the opening angle is not modified by the new gravitational
interactions. We also compare the dependence of the corner term on the new
gravitational couplings to that for a number of other physical quantities, and
we show that the ratio of the corner contribution over the central charge
appearing in the two-point function of the stress tensor is a universal
function for all of the holographic theories studied here. Comparing this
holographic result to the analogous functions for free CFT's, we find fairly
good agreement across the full range of the opening angle. However, there is a
precise match in the limit where the entangling surface becomes smooth, i.e.,
the angle approaches , and we conjecture the corresponding ratio is a
universal constant for all three-dimensional conformal field theories. In this
paper, we expand on the holographic calculations in our previous letter
arXiv:1505.04804, where this conjecture was first introduced.Comment: 62 pages, 6 figures, 1 table; v2: minor modifications to match
published version, typos fixe
The a-theorem and conformal symmetry breaking in holographic RG flows
We study holographic models describing an RG flow between two fixed points
driven by a relevant scalar operator. We show how to introduce a spurion field
to restore Weyl invariance and compute the anomalous contribution to the
generating functional in even dimensional theories. We find that the
coefficient of the anomalous term is proportional to the difference of the
conformal anomalies of the UV and IR fixed points, as expected from anomaly
matching arguments in field theory. For any even dimensions the coefficient is
positive as implied by the holographic a-theorem. For flows corresponding to
spontaneous breaking of conformal invariance, we also compute the two-point
functions of the energy-momentum tensor and the scalar operator and identify
the dilaton mode. Surprisingly we find that in the simplest models with just
one scalar field there is no dilaton pole in the two-point function of the
scalar operator but a stronger singularity. We discuss the possible
implications.Comment: 50 pages. v2: minor changes, added references, extended discussion.
v3: we have clarified some of the calculations and assumptions, results
unchanged. v4: published version in JHE
Microscopic unitary description of tidal excitations in high-energy string-brane collisions
The eikonal operator was originally introduced to describe the effect of
tidal excitations on higher-genus elastic string amplitudes at high energy. In
this paper we provide a precise interpretation for this operator through the
explicit tree-level calculation of generic inelastic transitions between closed
strings as they scatter off a stack of parallel Dp-branes. We perform this
analysis both in the light-cone gauge, using the Green-Schwarz vertex, and in
the covariant formalism, using the Reggeon vertex operator. We also present a
detailed discussion of the high energy behaviour of the covariant string
amplitudes, showing how to take into account the energy factors that enhance
the contribution of the longitudinally polarized massive states in a simple
way.Comment: 58 page
Effective AdS/renormalized CFT
For an effective AdS theory, we present a simple prescription to compute the
renormalization of its dual boundary field theory. In particular, we define
anomalous dimension holographically as the dependence of the wave-function
renormalization factor on the radial cutoff in the Poincare patch of AdS. With
this definition, the anomalous dimensions of both single- and double- trace
operators are calculated. Three different dualities are considered with the
field theory being CFT, CFT with a double-trace deformation and spontaneously
broken CFT. For the second dual pair, we compute scaling corrections at the UV
and IR fixed points of the RG flow triggered by the double-trace deformation.
For the last case, we discuss whether our prescription is sensitive to the AdS
interior or equivalently, the IR physics of the dual field theory.Comment: 20 pages, 3 figure
Analysis of the Influence of Sparkout Time on Grinding Using Several Lubrication/Cooling Methods
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The plunge cylindrical grinding operation has been widely employed in the manufacturing process of components which require excellent surface quality achieved within small ranges of dimensional tolerance. The sparkout time has proved to be an important parameter in this operation, contributing to obtain surfaces with high geometric and dimensional precision. This parameter, which is defined as the period in which there is no wheel radial feed, allows the elimination of elastic deformations that build up as the grinding wheel is fed. Experimentation with sparkout time was applied in the plunge cylindrical grinding operation and included the Minimum Quantity Lubrication (MQL) technique, which has proved to be an environmentally correct alternative, combining a small amount of lubricating oil with an intense flow rate of compressed air. The conventional lubrication and cooling method and the method involving the nozzle proposed by Webster [10] were also used. The results showed that longer sparkout times led to a decrease in tangential forces, wheel diametrical wear and surface roughness values for the MQL method.3114751Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP Sao Paulo State University at BauruFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP
Advances in understanding of air-sea exchange and cycling of greenhouse gases in the upper ocean
\ua9 2024 University of California Press. All rights reserved. The air–sea exchange and oceanic cycling of greenhouse gases (GHG), including carbon dioxide (CO2), nitrous oxide (N2O), methane (CH4), carbon monoxide (CO), and nitrogen oxides (NOx \ubc NO \ufe NO2), are fundamental in controlling the evolution of the Earth’s atmospheric chemistry and climate. Significant advances have been made over the last 10 years in understanding, instrumentation and methods, as well as deciphering the production and consumption pathways of GHG in the upper ocean (including the surface and subsurface ocean down to approximately 1000 m). The global ocean under current conditions is now well established as a major sink for CO2, a major source for N2O and a minor source for both CH4 and CO. The importance of the ocean as a sink or source of NOx is largely unknown so far. There are still considerable uncertainties about the processes and their major drivers controlling the distributions of N2O, CH4, CO, and NOx in the upper ocean. Without having a fundamental understanding of oceanic GHG production and consumption pathways, our knowledge about the effects of ongoing major oceanic changes—warming, acidification, deoxygenation, and eutrophication—on the oceanic cycling and air–sea exchange of GHG remains rudimentary at best. We suggest that only through a comprehensive, coordinated, and interdisciplinary approach that includes data collection by global observation networks as well as joint process studies can the necessary data be generated to (1) identify the relevant microbial and phytoplankton communities, (2) quantify the rates of ocean GHG production and consumption pathways, (3) comprehend their major drivers, and (4) decipher economic and cultural implications of mitigation solutions
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