Hemodynamic and inotropic effects of endothelin-1 in vivo

Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs. NaCl controls) hemodynamic and inotropic effects of ET-1 in 53 open-chest rats during and after a 7-min infusion. Besides measurements in the intact circulation the myocardial function was examined by isovolumic registrations independent of peripheral vascular effects. A transient ET-1 induced (500, 1000, 2500, 5000 ng ET-1/kg) decrease of the left ventricular systolic pressure (LVSP) and the mean aortic pressure (AoPmean) was followed by a dose-related rise of these pressures (LVSP: -1%, -1%, +8%, +16% vs. preinfusion values; AoPmean: -11%, +9%, +39%, +52%). Heart rate (HR) was not influenced by ET-1. Due to the dose-dependent decrease of the stroke volume (SV) the cardiac output (CO) was reduced (CO: -8%, -23%, -40%, -50%). After an initial vasodilatation ET-1 elevates the total peripheral resistance (TPR: -1%, +49%, +139%, +215%) dose-dependently. 10,000 ng ET-1/kg was a lethal dose resulting in cardiac failure within minutes (low output). Since the maximum of the isovolumic LVSP (peak LVSP) and the corresponding dP/dtmax (peak dP/dtmax) were unchanged under ET-1, the isovolumic measurements do not indicate a positive inotropic effect of ET-1 in vivo in contrast to published results of in vitro experiments. It may be possible that a direct positive inotropic effect of ET-1 observed in in vitro studies is counterbalanced in vivo by an indirect negative inotropic effect due to the coronary-constrictive effect of ET-1

Comparison of Oxygenation Trends in the Latissimus Dorsi Across Handle Types During Seated Row Exercise

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Violations of Lorentz Covariance in Light Front Quark Models

Electromagnetic form factors of the nucleon from relativistic quark models are analyzed: results from null-plane projection of the Feynman triangle diagram are compared with a Bakamjian-Thomas model. The magnetic form factors of the models differ by about 15% at spacelike momentum transfer 0.5 GeV^2, while the charge form factors are much closer. Spurious contributions to electromagnetic form factors due to violations of rotational symmetry are eliminated from both models. One method changes magnetic form factors by about 10%, whereas the charge form factors stay nearly the same. Another one changes the charge form factor of the Bakamjian-Thomas model by more than 50%.Comment: 19 pages, 9 figures, Late

Macroscopic evidence for quantum criticality and field-induced quantum fluctuations in cuprate superconductors

We present macroscopic experimental evidence for field-induced microscopic quantum fluctuations in different hole- and electron-type cuprate superconductors with varying doping levels and numbers of CuO$_2$ layers per unit cell. The significant suppression of the zero-temperature in-plane magnetic irreversibility field relative to the paramagnetic field in all cuprate superconductors suggests strong quantum fluctuations due to the proximity of the cuprates to quantum criticality.Comment: 3 figures. To appear in Phys. Rev. B, Rapid Communications (2007). For correspondence, contact: Nai-Chang Yeh (e-mail: [email protected]

Exploring Deep Space: Learning Personalized Ranking in a Semantic Space

Recommender systems leverage both content and user interactions to generate recommendations that fit users' preferences. The recent surge of interest in deep learning presents new opportunities for exploiting these two sources of information. To recommend items we propose to first learn a user-independent high-dimensional semantic space in which items are positioned according to their substitutability, and then learn a user-specific transformation function to transform this space into a ranking according to the user's past preferences. An advantage of the proposed architecture is that it can be used to effectively recommend items using either content that describes the items or user-item ratings. We show that this approach significantly outperforms state-of-the-art recommender systems on the MovieLens 1M dataset.Comment: 6 pages, RecSys 2016 RSDL worksho

Experimental investigation of the competing orders and quantum criticality in hole- and electron-doped cuprate superconductors

We investigate the issues of competing orders and quantum criticality in cuprate superconductors via experimental studies of the high-field thermodynamic phase diagrams and the quasiparticle tunneling spectroscopy. Substantial field-induced quantum fluctuations are found in all cuprates investigated, and the corresponding correlation with quasiparticle spectra suggest that both electron- (n-type) and hole-doped (p-type) cuprate superconductors are in close proximity to a quantum critical point that separates a pure superconducting (SC) phase from a phase consisting of coexisting SC and a competing order. We further suggests that the relevant competing order is likely a spin-density wave (SDW) or a charge density wave (CDW), which can couple efficiently to an in-plane Cu-O bond stretching longitudinal optical (LO) phonon mode in the p-type cuprates but not in the n-type cuprates. This cooperative interaction may account for the pseudogap phenomenon above T, only in the p-type cuprate superconductors

Fish oil in infancy protects against food allergy in Iceland-Results from a birth cohort study

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesBACKGROUND: Consumption of oily fish or fish oil during pregnancy, lactation and infancy has been linked to a reduction in the development of allergic diseases in childhood. METHODS: In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at 1 and 2 years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double-blind, placebo-controlled food challenge if the allergy testing or clinical history indicated food allergy. The study investigated the development of sensitization to food and confirmed food allergy according to age and frequency of postnatal fish oil supplementation using proportional hazards modelling. RESULTS: The incidence of diagnosed food sensitization was significantly lower in children who received regular fish oil supplementation (relative risk: 0.51, 95% confidence interval: 0.32-0.82). The incidence of challenge-confirmed food allergy was also reduced, although not statistically significant (0.57, 0.30-1.12). Children who began to receive fish oil in their first half year of life were significantly more protected than those who began later (P = .045 for sensitization, P = .018 for allergy). Indicators of allergy severity decreased with increased fish oil consumption (P = .013). Adjusting for parent education and allergic family history did not change the results. CONCLUSION: Postnatal fish oil consumption is associated with decreased food sensitization and food allergies in infants and may provide an intervention strategy for allergy prevention.European Commission Landspitali University Hospital Science Fund GlaxoSmithKline Icelan

In-medium nucleon-nucleon potentials in configuration space

Based on the thermodynamic Green function approach two-nucleon correlations in nuclear matter at finite temperatures are revisited. To this end, we derive phase equivalent effective $r$-space potentials that include the effect of the Pauli blocking at a given temperature and density. These potentials enter into a Schr\"odinger equation that is the $r$-space representation of the Galitskii-Feynman equation for two nucleons. We explore the analytical structure of the equation in the complex $k$-plane by means of Jost functions. We find that despite the Mott effect the correlation with deuteron quantum numbers are manifested as antibound states, i.e., as zeros of the Jost function on the negative imaginary axis of the complex momentum space. The analysis presented here is also suited for Coulombic systems.Comment: 6 pages, 1 table, 4 figure

Effect of the curvature and the {\beta} parameter on the nonlinear dynamics of a drift tearing magnetic island

We present numerical simulation studies of 2D reduced MHD equations investigating the impact of the electronic \beta parameter and of curvature effects on the nonlinear evolution of drift tearing islands. We observe a bifurcation phenomenon that leads to an amplification of the pressure energy, the generation of E \times B poloidal flow and a nonlinear diamagnetic drift that affects the rotation of the magnetic island. These dynamical modifications arise due to quasilinear effects that generate a zonal flow at the onset point of the bifurcation. Our simulations show that the transition point is influenced by the \beta parameter such that the pressure gradient through a curvature effect strongly stabilizes the transition. Regarding the modified rotation of the island, a model for the frequency is derived in order to study its origin and the effect of the \beta parameter. It appears that after the transition, an E \times B poloidal flow as well as a nonlinear diamagnetic drift are generated due to an amplification of the stresses by pressure effects